A New Human Case of Anixiopsis stercomia Mycosis: Discnssion of its Taxonomy and Pathogenicity: Ein neuer Fall einer Mykose durch Anixiopsis stercoraria: Diskussion der Taxonomie und der Pathogenität

Summary: Anixiopsis stercoraria, a keratmophflic fungus frequently isolated from soil is occasionally pathogenic for humans and animals causing dermatophytosis-like lesions. However, this species, which presents a Chiysosporinm asexual state, is not a true dermatophyte and the lesions disappear spontaneously or after a short antifrmgal treatment (antidermatophytic). Report on a case of a ten year old boy with lesions on the scalp which clinically appeared to be typical for tinea capitls. The different fungal isolates from these lesions are discussed in connection with the pathology.
Zusammenfassung: Anixiopsis stercoraria 1st em keratinophuer Bodenpilz, der gelegentlich bei Menschen und Tieren Hantreändenmgen hervonuft, die einer Dermatophytose ähnem. Diese Art, die ein asexuelles Stadium von Chysosporium darstellt, ist jedoch selbst kein echter Dermatophyt. Die Hantrerändenrngen hellen spontan oder unter anthnykotischer (antidermato-phytischer) Behandhmg ab. Es wird der Fall eines Uphrigen Jungen berichtet, bei dem skh am Kopf für Tinea capitis typische Herde entwickelt batten. Die isotterten Pflze werden in Verbin-dung mit der Pathotogie diskutiert     

Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight.

Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson's disease (PD) patients after subthalamic deep brain stimulation (STN-DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 +/- 7 kg) and BMI increase (+ 4.7 kg/m2). The fat mass was higher after STN-DBS. Resting EE (REE; offdrug/ON stimulation) was significantly decreased in STN-DBS patients, while their daily energy expenditure (DEI) was not significantly different. A significant correlation was found among WG, BMI increase, and pre-operative levodopa-equivalent daily dose, their reduction after STN-DBS, and the differential REE related to stimulation and the REE in the offdrug/OFF stimulation condition. In conclusion, STN-DBS in PD induces a significant WG associated with a reduction in REE without DEI adjustment.     

Reduced efficacy of clinical probability score and D-dimer assay in elderly subjects suspected of having deep vein thrombosis

The combined strategy of a pretest clinical probability (PCP) score and D-dimer has shown to be of value in the diagnosis of deep vein thrombosis (DVT). As D-dimer concentrations increase with age, the effect of age on the usefulness of this strategy was retrospectively investigated in outpatients suspected of having DVT. In all patients, participants of a prospective management trial, a PCP score and D-dimer (Tina-quant) were performed. In a total of 812 patients, 317 (39%) had thrombosis. Patients were divided into quartiles according to their age. Sensitivity and negative predictive value of a low/moderate PCP score and a normal D-dimer were 98-100% and did not differ between the different age quartiles. Specificity in the highest quartile was 17.4% compared with 49.2% in the youngest (P < 0.000001). The proportion of patients with a low/moderate PCP score and a normal D-dimer decreased with age: 12% in the highest quartile (>73.8 years) versus 25% in younger patients (P = 0.00005). We therefore conclude that the combined strategy of a low/moderate PCP score with a normal D-dimer test is safe for excluding DVT in all age groups, but is less useful in the elderly.     

Trichodermamide A and aspergillazine A, two cytotoxic modified dipeptides from a marine-derived fungusSpicaria elegans

Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.     

Non-penetrating deep sclerectomy without or with autologous scleral implant in open-angle glaucoma: medium-term results

Background This study compares the medium-term success rate and complications of non-penetrating deep sclerectomy (NPDS) without and with autologous scleral implant in open-angle glaucoma. Methods Retrospective review of 93 eyes of 93 patients with medically uncontrolled open-angle glaucoma who underwent NPDS without (n=69, group 1) or with (n=24, group 2) autologous scleral implant. Results The mean follow-up was 16 months (range 5–36) in group 1 and 15 months (range 4–28) in group 2. The mean intra-ocular pressures (IOP) pre- and postoperatively were, respectively, 23.8 and 16.1 mmHg in group 1, and 25.6 and 15.8 mmHg in group 2. The absolute success rate was 41% in group 1 and 54% in group 2. The qualitative success rate was 83% in group 1 and 75% in group 2. An IOP lower than 16 mmHg was obtained in 51% of patients in group 1 and 58% of patients in group 2. A Nd:YAG laser goniopuncture was performed in 30% of patients in group 1 and 50% of patients in group 2, and resulted in a better controlled IOP. Conclusions NPDS without or with an autologous scleral implant is a safe procedure reducing the IOP significantly, but probably not sufficient when an IOP below 16 mmHg is required. We found no statistically significant difference between the two groups.     

Intestinal surgical resection disrupts electrical rhythmicity, neural responses, and interstitial cell networks

BACKGROUND & AIMS: Surgical manipulations of the gastrointestinal (GI) tract, including intestinal resection and anastomosis, lead to motility disorders including a decrease in phasic and segmental contractions. The aims of the present investigation were to determine mechanisms underlying the loss of motility in a murine model of intestinal resection and to follow-up the recovery of intestinal motility after surgical manipulation. METHODS: Segments of ileum were removed from mice and the intestines were reconstructed. After surgery, the structure and activity of the ileal muscles, 0-5 cm oral and aboral to the site of resection, were examined at 5 and 24 hours with intracellular microelectrode recordings, isometric force measurements, Kit-like immunohistochemistry, and electron microscopy. RESULTS: Five hours after surgery there was loss of electrical slow waves and phasic contractions in muscles near the site of resection. This defect decreased as a function of distance above and below the resection. Tissues in the affected region were poorly responsive to carbachol and transmural nerve stimulation. Kit-like immunohistochemistry revealed disruption in interstitial cell of Cajal (ICC) networks at the level of the myenteric and deep muscular plexuses. Lesions in ICCs decreased with distance from the site of resection. Slow waves and mechanical activity recovered at the site of anastomosis 24 hours after surgery and recovered more rapidly when tissues were incubated in the inducible nitric oxide synthase (iNOS) inhibitor, L-N6 -(1-Iminoethyl) lysine hydrochloride (L-NIL). CONCLUSIONS: Loss of intestinal motility after surgery is associated with acute disruption of ICC networks, slow waves, and phasic contractions. This activity partially recovered within 24 hours after surgery.     

Deep vein thrombosis in patients with multiple myeloma treated with thalidomide and chemotherapy: effects of prophylactic and therapeutic anticoagulation

A group of 256 newly diagnosed myeloma patients were enrolled in a phase III study that included 4 monthly cycles of induction chemotherapy and tandem transplant. All patients were randomized to either receive or not receive thalidomide. A total of 221 patients (86%) received no prophylactic anticoagulation (cohort I); 35 patients received low dose coumadin (cohort II). The incidence of deep vein thrombosis (DVT) was significantly higher in the thalidomide arm hazard ratio: 4.5; P < 0.0001). As low dose coumadin (1 mg/d) failed to decrease thrombotic complications in 35 patients (cohort II), low molecular weight heparin (LMWH, enoxaparin 40 mg s.c. q.d.) was instituted as DVT prophylaxis in the thalidomide-treated patients (n = 68) of the subsequent cohort (n = 130, cohort III). This intervention eliminated the difference in DVT incidence between the two arms (thalidomide and no thalidomide). Within cohorts I and II, 36 patients, in whom thalidomide was discontinued after experiencing a thrombotic episode during chemotherapy, subsequently resumed the drug on full anticoagulation; with a median follow-up of 22 months, DVT recurred in four patients (11%). After completing induction and tandem transplantation, 55 patients were re-exposed to thalidomide and chemotherapy during consolidation treatment. Thrombotic complications were observed in 4%. Our experience, although not based on a randomized study, suggests that the excess frequency of thrombosis in patients treated with chemotherapy and thalidomide can be safely reduced by the prophylactic use of LMWH. The rate of DVT recurrence observed in our study upon thalidomide resumption was sufficiently low to allow its continuation in patients who may benefit from this therapeutic intervention.     

深Ⅱ度烧伤愈合后Bcl-xl、Bax蛋白表达与增生性瘢痕的相关性

目的探讨Bcl-xl和Bax蛋白在深Ⅱ度烧伤愈合后不同时期增生性瘢痕中的表达特点。方法人深Ⅱ度烧伤愈合后不同时期的增生性瘢痕皮肤40例,正常皮肤组织10例。分为增生期组、减退早期组、减退晚期组、成熟期组,正常对照组。免疫组织化学染色,检测Bcl-xl和Bax蛋白的表达。结果深Ⅱ度烧伤创面愈合后,Bcl-xl和Bax蛋白主要表达于表皮基底细胞和真皮层成纤维细胞,增生期和减退早期Bcl-xl和Bax蛋白产物光密度值明显高于正常皮肤(p<0.01),减退晚期和成熟期随瘢痕成熟而逐渐递减接近正常皮肤。结论 Bcl-xl和Bax蛋白表达与深Ⅱ度烧伤创面愈合后增生性瘢痕的发生和瘢痕成熟相关。     

Turner综合征合并海蓝组织增多症一例并文献复习

目的探讨先天性卵巢发育不全综合征与海蓝组织增多症的相关性,为诊断及治疗提供依据。方法对1例Turner综合征合并海蓝组织增多症患者的临床资料进行回顾性分析并进行文献复习。结果该例患者本次发病主要为抵抗力低下所致呼吸系统感染,经抗炎及对症支持治疗,目前已恢复平素状态。结论 Turner综合征为染色体缺陷疾病,可伴有多种激素水平的改变,海蓝组织增多症亦可由原发性染色体缺陷引起或继发于激素水平改变引起。体内雌二醇、睾酮、泌乳素及生长激素等多种激素的部分或全部缺失,以及伴随的糖脂代谢紊乱,使得Turner综合征与SBH两者之间的相关性有待于更多,更完善的相关资料的支持。     

D-D和抗凝蛋白检测在下肢深静脉血栓形成患者诊治中的意义

目的 研究下肢深静脉血栓形成（LDVT）的主要发病机制.方法 应用日本Sysmex CA7000型全自动血液凝固仪检测55例LDVT患者（38例初发,17例复发）和60例健康人的血浆D-二聚体（D-dimer,D-D）、抗凝血酶（AT）、蛋白S（PS）,蛋白C（PC）的活性水平.结果 LDVT组与正常对照组相比、LDVT复发组与初发组相比,AT、PS、PC活性明显降低,D-D水平明显升高,均有极显著差异（P〈0.01）.结论 D-D水平升高和先天性或获得性抗凝蛋白缺陷是LDVT发病和复发的重要原因.因此有必要对LDVT患者进行D-D水平和抗凝蛋白水平的筛选.