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11.
12.
液体衰减翻转恢复序列在颅脑MRI中的应用 总被引:7,自引:0,他引:7
目的:探讨1.5TMR颅脑液体衰减翻转恢复(FLAIR)序列的合理扫描参数及其临床应用价值。材料和方法:首先对18名健康志愿者行1.5TMR的颅脑FLAIR序列的参数选择试验,然后用筛选出的合理参数对24例脑部疾病患者行FLAIR序列与SE序列的对照扫描。结果:在1.5TMR颅脑FLAIR扫描中,当TR=6000ms时,TI为1700-1800ms接近脑脊液的无效值,TE以160ms为宜。FLAIR序列与SE序列的对照扫描中,FLAIR序列显示病变为75/76(98.68%),SE序列为65/76(85.53%),两者显示病变的敏感度有显著性差异(P<0.01)。结论:FLAIR序列对靠近脑脊液的病变、脑组织水肿、室管膜下漏液、脑室和脑池内病变的检出较SE序列更敏感。 相似文献
13.
The detection of a change in a face stimulus was studied in an oddball paradigm. Event-related potentials (ERPs) and MEG responses to face stimuli were recorded in four conditions: 1) happy standard, neutral deviant; 2) neutral standard, neutral deviant; 3) inverted happy standard, inverted neutral deviant; 4) inverted neutral standard, inverted neutral deviant. In all conditions, the target was a face with glasses. Neutral deviants elicited a negative deflection (with a maximum around 280 ms) in ERP and MEG responses, an effect similar to auditory mismatch negativity. Face inversion diminished deviance-related negativity, implying an important role of face recognition in the observed effect. Emotional content and larger physical differences between stimuli in conditions 1 and 3 compared to conditions 2 and 4 did not show statistically significant effect on the neutral-deviant-related negativity. 相似文献
14.
《The Knee》2022
BackgroundKnee osteoarthritis (KOA) is increasingly prevalent in North American society. The significant societal burden it represents makes it essential to promote and target new treatments in earlier phases of the disease. Among others, subchondroplasty is a newly documented technique using calcium phosphate injection targeting the osteochondral lesions preceding KOA, also known as Bone Marrow Lesions (BMLs). This article aimed to review the existing literature on clinical and radiological outcomes of subchondroplasty in the treatment of BMLs in KOA.MethodA systematic review was performed using PubMed, Embase, Medline and Cochrane Database of Systematic Reviews. Studies on calcium phosphate injections into BMLs for KOA and its clinical and radiological outcomes were screened and reviewed by independent evaluators.ResultsAfter screening, ten articles were included, totaling 540 patients. Follow-up ranged from 6 months to 7 years. Overall, the procedure showed significant functional and quality of life improvement, as well as pain relief, as shown by Patients-Reported Outcomes Measures (PROMs). There were very few complications reported, the most important being leakage of calcium phosphate outside the targeted site. Conversion rate to total knee arthroplasty (TKA) ranged from 14 % to 30 % at 2 years post-procedure. Long term radiological outcomes have been poorly documented.ConclusionsSubchondroplasty is a promising avenue for the treatment of KOA. However, quality evidence is still required before any real conclusions and practical management guidelines can be drawn. Prospective, randomized studies with a control group and a rigorous assessment of long-term clinical and radiological outcomes are recommended. 相似文献
15.
Summary The aim of the present study was to investigate the chronic effects of a dietetic antihypertensive treatment on blood pressure, ventricular dynamics and geometry of the pressure loaded heart. Spontaneously hypertensive rats (SHR) received a standard diet enriched with 10% mackerel oil, containing 30% polyunsaturated Q-3 fatty acids, over a period of 70 days. As described previously the diet reduced blood pressure permanently by 40-50 mm Hg. Despite this reduction, the degree of left ventricular hypertrophy was only slightly (statistically insignificantly) reduced. This was probably a result of an increase in sympathetic tone as indicated by a raised pulse rate. On the other hand, the treatment prevented the development of eccentric hypertrophy, typical to the SHR, without changing the elastic material properties of the myocardium. Since the age-matched controls did not show significant degenerative alterations, protective effects at the level of myocardial tissue could not be demonstrated. Furthermore, future investigations need to investigate why myocardial contractility of the treated animals diminishes as observed in this study. 相似文献
16.
26例9号染色体臂间倒位的表型效应的探讨 总被引:1,自引:0,他引:1
目的探讨9号染色体臂间倒住的临床及遗传效应。方法通过对外周血淋巴细胞培养,制备染色体。G显带染色体分析。结果2317例病人中检出26例9号染色体臂间倒位(1.12%),其中有15例患者(占58%)伴有流产、不育、不孕、胎儿畸形等临床表现,2例合并有染色体数目异常。结论9号染色体臂间倒位具有一定遗传效应不应忽视。 相似文献
17.
Miguel Urioste María Luisa Martínez-Frías Eva Bermejo Nicols Jimnez Dolores Romero Carmen Nieto Amelia Villa 《American journal of medical genetics. Part A》1994,49(1):94-97
We report on a newborn infant with clinical and radiological manifestations of some type of short rib-polydactyly syndrome who died soon after birth. Chromosomal studies on peripheral blood lymphocytes and chondrocytes demonstrated an apparently balanced pericentric inversion of chromosome 4 (present in the mother also). This association may have occurred by chance but, if not, the chromosomal breakpoints could interrupt the gene responsible for short rib-polydactyly syndromes, or else be related to the mechanism of short rib-polydactyly syndromes. © 1994 Wiley-Liss, Inc. 相似文献
18.
A male infant is described in whom congenital anomalies were recognized prenatally by ultrasound examination. The infant was delivered following spontaneous labor and died approximately 15 min after birth. An autopsy revealed major anomalies in the central nervous system (holoprosencephaly with premaxillary agenesis), the gastrointestinal system (esophageal atresia) and the heart (tetralogy of Fallot). Chromosomal studies revealed recombinant chromosome 5 [46,XY, rec(5), dup q, inv(5)(p15q32)], resulting in partial trisomy 5q and partial monosomy 5p. Cytogenetic investigation of the family revealed a pericentric inversion of chromosome 5 in the father and paternal grandmother, 46,XY (and XX, respectively,) inv(5)(p15q32). The congenital anomalies in this infant are more extensive and severe than previously reported in cases of recombination aneusomy involving chromosome 5. 相似文献
19.
A case of Klinefelter's Syndrome with a paracentric inversion in chromosome 12 is described. The karyotype was determined to be 47, XXY, inv(12)(q15q24) and the significance of the breakpoints on chromosome 12 is discussed. 相似文献
20.
Pericentric inversions of chromosome 4: report of a new family and review of the literature 总被引:1,自引:0,他引:1
A. Villa M. Urioste M. C. Carrascosa S. Vázquez A. Martínez M. L. Martínez-Frías 《Clinical genetics》1995,48(5):255-260
A family was cytogenetically studied because of the birth of a male child with a multiple congenital anomaly pattern, in whom a dup (4q) recombinant was found. His phenotypically normal mother's karyotype showed an apparently balanced pericentric inversion in a chromosome 4. So as to analyze the occurrence of recombinants, the cytogenetic data from this family are compared with those of the 18 previously reported familial cases of pericentric inversions (PIs) of chromosome 4. The congenital anomalies observed in the child strongly suggest Wolf-Hirschhorn syndrome but some of his clinical features seem to be pathogenetically related to the presence of lymphedema during the intrauterine period. In the multiple congenital anomaly pattern observed in this patient, the lymphedema could be the consequence of the large 4q duplication. The review of chromosome 4 PIs with 4q duplication suggests that the q3 region should be examined when edema is detected prenatally. 相似文献