全文获取类型
收费全文 | 1983篇 |
免费 | 83篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 57篇 |
妇产科学 | 116篇 |
基础医学 | 176篇 |
口腔科学 | 85篇 |
临床医学 | 155篇 |
内科学 | 235篇 |
皮肤病学 | 14篇 |
神经病学 | 121篇 |
特种医学 | 53篇 |
外科学 | 270篇 |
综合类 | 174篇 |
预防医学 | 171篇 |
眼科学 | 15篇 |
药学 | 141篇 |
1篇 | |
中国医学 | 29篇 |
肿瘤学 | 231篇 |
出版年
2023年 | 22篇 |
2022年 | 41篇 |
2021年 | 74篇 |
2020年 | 54篇 |
2019年 | 146篇 |
2018年 | 96篇 |
2017年 | 74篇 |
2016年 | 45篇 |
2015年 | 41篇 |
2014年 | 142篇 |
2013年 | 119篇 |
2012年 | 83篇 |
2011年 | 131篇 |
2010年 | 96篇 |
2009年 | 90篇 |
2008年 | 86篇 |
2007年 | 82篇 |
2006年 | 57篇 |
2005年 | 53篇 |
2004年 | 47篇 |
2003年 | 40篇 |
2002年 | 29篇 |
2001年 | 33篇 |
2000年 | 27篇 |
1999年 | 26篇 |
1998年 | 20篇 |
1997年 | 25篇 |
1996年 | 21篇 |
1995年 | 23篇 |
1994年 | 20篇 |
1993年 | 10篇 |
1992年 | 13篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1989年 | 10篇 |
1988年 | 9篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 18篇 |
1984年 | 36篇 |
1983年 | 22篇 |
1982年 | 15篇 |
1981年 | 11篇 |
1980年 | 12篇 |
1979年 | 8篇 |
1978年 | 15篇 |
1977年 | 8篇 |
1976年 | 5篇 |
1975年 | 8篇 |
1973年 | 4篇 |
排序方式: 共有2078条查询结果,搜索用时 93 毫秒
21.
22.
Thomas Powles Michael B. Atkins Bernard Escudier Robert J. Motzer Brian I. Rini Lawrence Fong Richard W. Joseph Sumanta K. Pal Mario Sznol John Hainsworth Walter M. Stadler Thomas E. Hutson Alain Ravaud Sergio Bracarda Cristina Suarez Toni K. Choueiri James Reeves Allen Cohn David F. McDermott 《European urology》2021,79(5):665-673
BackgroundThe use of immune checkpoint inhibitors combined with vascular endothelial growth factor (VEGF)-targeted therapy as second-line treatment for metastatic clear cell renal cancer (mRCC) has not been evaluated prospectively.ObjectiveTo evaluate the efficacy and safety of atezolizumab + bevacizumab following disease progression on atezolizumab or sunitinib monotherapy in patients with mRCC.Design, setting, and participantsIMmotion150 was a multicenter, randomized, open-label, phase 2 study of patients with untreated mRCC. Patients randomized to the atezolizumab or sunitinib arm who had investigator-assessed progression as per RECIST 1.1 could be treated with second-line atezolizumab + bevacizumab.InterventionPatients received atezolizumab 1200 mg intravenously (IV) plus bevacizumab 15 mg/kg IV every 3 wk following disease progression on either atezolizumab or sunitinib monotherapy.Outcome measurements and statistical analysisThe secondary endpoints analyzed during the second-line part of IMmotion150 included objective response rate (ORR), progression-free survival (PFS), and safety. PFS was examined using Kaplan-Meier methods.Results and limitationsFifty-nine patients in the atezolizumab arm and 78 in the sunitinib arm were eligible, and 103 initiated second-line atezolizumab + bevacizumab (atezolizumab arm, n = 44; sunitinib arm, n = 59). ORR (95% confidence interval [CI]) was 27% (19–37%). The median PFS (95% CI) from the start of second line was 8.7 (5.6–13.7) mo. The median event follow-up duration was 19.4 (12.9–21.9) mo among the 25 patients without a PFS event. Eighty-six (83%) patients had treatment-related adverse events; 31 of 103 (30%) had grade 3/4 events. Limitations were the small sample size and selection for progressors.ConclusionsThe atezolizumab + bevacizumab combination had activity and was tolerable in patients with progression on atezolizumab or sunitinib. Further studies are needed to investigate sequencing strategies in mRCC.Patient summaryPatients with advanced kidney cancer whose disease had worsened during treatment with atezolizumab or sunitinib began second-line treatment with atezolizumab + bevacizumab. Tumors shrank in more than one-quarter of patients treated with this combination, and side effects were manageable. 相似文献
23.
Cervical preparation with laminaria reduces complications with 2nd trimester dilation and evacuation. During a surgical abortion at 22 weeks, we could not remove laminaria manually or with ring forceps due to laminaria “dumbbelling” [1]. Without pushing laminaria into the uterus, we mechanically dilated the cervix and removed the incarcerated laminaria. 相似文献
24.
Martin C. Michel Gertraud Hanft Gerhard Gross 《Naunyn-Schmiedeberg's archives of pharmacology》1990,341(4):385-387
Summary We used novel highly subtype-selective antagonists to study whether 1A- and/or 1B-adrenoceptors mediate the stimulation of inositol phosphate generation by noradrenaline in rat cerebral cortex. Phentolamine (10 M) and prazosin (100 nM) completely abolished the stimulated inositol phosphate generation. The 1A-selective antagonists 5-methyl-urapidil (100 nM) and (+)– and (–)-niguldipine (10 nM) caused only weak inhibition or none at all although these concentrations occupied 1A-adrenoceptors almost completely. In contrast, pretreatment with the irreversible 1B-selective chloroethylclonidine reduced the noradrenaline-stimulated inositol phosphate generation by 76 ± 8%. These data demonstrate that 1B-adrenoceptors couple to inositol phosphate generation; the signal transduction system of 1A-adrenoceptors remains unclear.
Send offprint requests to G. Gross at the above address 相似文献
25.
26.
27.
Mechanisms governing the relative proportions of thyroxine and 3,5,3'-triiodothyronine in thyroid secretion 总被引:2,自引:0,他引:2
P Laurberg 《Metabolism: clinical and experimental》1984,33(4):379-392
In subjects with normal thyroid function only a minor part of firculating 3,5,3'-triiodothyronine (T3) originates directly from the thyroid; the majority is produced in the peripheral tissues by deiodination of thyroxine (T4). However, T3 of thyroidal origin constitutes a relatively high fraction of the total T3 produced in many patients with thyroid hyperfunction or hypofunction. Such a relatively high T3 content in the secretion of the thyroid could be caused by a low T4/T3 ratio in thyroglobulin. Severe iodine deficiency is a well-known inducer of a low T4/T3 ratio, but a low T4/T3 ratio can also be produced independent of the iodine content. This is seen in in vitro studies of thyroglobulin iodination when small amounts of DIT are added to the incubation mixture and in vivo in TSH-treated animals and in patients with Graves' disease. Another mechanism for high thyroidal secretion of T3 could be an enhanced fractional deiodination of T4 to T3 in the thyroid. In vitro thyroid perfusion studies have shown that the T3 content of thyroid secretions is higher than would be expected from the T4/T3 ratio of thyroid hydrolysate and that the major mechanism is deiodination of T4 to T3. Thyroxine deiodinases are also present in the human thyroid, and the amount of T4 deiodinase is enhanced in the thyroids from patients with medically treated Graves' disease and in the hyperstimulated thyroids of rats. Other factors of possible importance for the mixture of T3 and T4 secreted by the thyroid are a relatively faster liberation of T3 than of T4 from thyroglobulin during partial hydrolysis (this faster release of T3 is probably the mechanism behind the more "rapid" secretion of T3 than of T4), or some kind of thyroid heterogeneity leading to pinocytosis and hydrolysis of thyroglobulin with a lower T4/T3 ratio than that of average thyroglobulin. 相似文献
28.
G. H. Willital C. Krebs und H. Meier 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1979,349(1):535
Zusammenfassung In 10 Jahren werden 130 Kinder wegen eines Dunndarmileus operiert. In 45 Fallen war die Ursache des Dunndarmileus eine vorausgegangene Laparotomie. Bei 13 dieser 45 Relaparotomien mußte erneut eine Laparotomie durchgeführt werden. In 40 % der Relaparotomiefälle war ein durchblutungsgestörter Darm die Ursache dafür. Funktions- and durchblutungsgestörte, dilatierte, hypertrophierte and atonische Darmanteile, die für die normale Peristaltik ungeeignet sind, sollen durch eine erweiterte Resektion des Dünndarms reseziert werden (Anastomose vitaler Diinndarmabschnitte). 相似文献
29.
30.
山东某市二次供水水质卫生状况分析 总被引:4,自引:0,他引:4
目的:探讨二次供水系统中蓄水池(箱)等蓄水设施对水质的影响状况。方法:对2001~2004年滨州市区直接供水与二次供水23项卫生监测指标进行分析。检测方法按GB5750—85《生活饮用水标准检验方法》,评价依据按GB5749—85《生活饮用水卫生标准》。监测指标包括浑浊度、总铁、细菌总数、大肠菌群、氨氮、亚硝酸盐氮、硝酸盐氮。结果:二次供水合格率仅为12.2%,与城市供水管网末梢水水质相比较差异有统计学意义。结论:二次供水污染严重,应引起高度重视。 相似文献