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11.
K. M. Mitchell R. J. Hale C. H. Buckley H. Fox D. Smith 《Virchows Archiv : an international journal of pathology》1993,422(5):357-360
An immunohistochemical study was made of cathepsin-D protein expression in each of the three main types of uterine cervical carcinoma (squamous carcinoma, adenosquamous carcinoma and adenocarcinoma) with particular reference to lymph node status and prognosis. Of the 61 cases, 54.1% showed cytoplasmic staining in more than 2.5% of tumour cells counted. Cathepsin-D expression was significantly higher in adenocarcinoma (mean -3.128) than in squamous carcinoma and adenosquamous carcinoma (mean –3.709,P=0.047 using logit transformation). Cathepsin-D had no prognostic value in any of the three tumour types. No relationship was found between cathepsin-D staining and lymph node status and there was no advantage in adding cathepsin-D values to lymph node status. These results suggest that immunostaining for cathepsin-D protein expression is unlikely to be of use as a prognostic marker. 相似文献
12.
Prognostic value of MMP-2, -9 and TIMP-1,-2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas 总被引:10,自引:0,他引:10
Ondruschka C Buhtz P Motsch C Freigang B Schneider-Stock R Roessner A Boltze C 《Pathology, research and practice》2002,198(8):509-515
In head and neck cancer as well as in other carcinomas, tumor expansion and spread to distant sites require the secretion of destructive enzymes that degrade the extracellular matrix. A variety of proteases contribute to matrix destruction. Characteristics of the invasive tumor front may reflect tumor prognosis better than do other parts of the tumor. Therefore, it was the aim of the present study to (i) compare central and peripheral tumor zones for differences in the expression of matrix-metalloproteinases (MMP) -2 and -9 and their naturally occurring inhibitors (tissue inhibitor of matrix-metalloproteinases (TIMP) -1 and -2), (ii) examine the morphological potential of malignancy, and (iii) correlate these findings with clinicopathological parameters. The study population consisted of 106 surgical specimens of advanced head and neck squamous cell carcinomas. The invasive front was graded for malignancy, and immunohistochemical staining with MMP-2, MMP-9, TIMP-1 and TIMP-2 antibodies was performed. Both MMP-2 and MMP-9 were found to be significantly overexpressed at the tumor front. The MMP-2-positive invasive front exhibited diminished overall survival times. In multivariate analysis, MMP-2 expression retained its correlation with overall survival in addition to nodal status and total malignancy score. Expression of TIMP-2 correlated with local tumor invasion. We conclude that the expression of MMP-2 at the invasive front is a marker of poor survival and appears to be associated with early recurrence in initially lymph node-negative patients. 相似文献
13.
1目的 探求多发性骨髓瘤骨髓细胞学特性与预后的关系。 2方法 回顾性调查 ,两个样本均数的 t检验 ,多个样本均数的方差分析 ,二元线性回归分析。 3结果 成浆细胞型 MM与幼浆细胞型 MM比较 ,生存期差异显著 (P<0 .0 5 ) ,而各骨髓有核细胞增生程度间的 MM生存期则差异无显著性 (P>0 .0 5 ) ,瘤细胞比例的高低与生存期呈直线负相关。 4结论 幼浆细胞型 MM和瘤细胞比例高的 MM预后差 相似文献
14.
目的 为探讨充血性心力衰竭 (CHF)患者甲状腺素水平及其与预后的关系。方法 观测了 2 5例CHF患者 (治疗组 )治疗前后及同期 3 0例健康体检者 (对照组 )血浆甲状腺激素水平的变化。结果 治疗组T3水平明显低于对照组 ,且治疗组T3水平随心功能的恶化而降低 ,随治疗好转而回升 ,而T4 则明显波动。结论 CHF患者心功能与T3浓度有密切关系 ,还可降低外周血管阻力 ,减轻心脏后负荷 相似文献
15.
16.
Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature 总被引:3,自引:0,他引:3
Uluoğlu O Akyürek N Uner A Coşkun U Ozdemir A Gökçora N 《Virchows Archiv : an international journal of pathology》2005,446(5):546-554
Interdigitating dendritic cell tumor (IDCT) is an extremely rare malignancy. It occurs primarily in lymph nodes, but extranodal involvement has also been reported. A 38-year-old woman with IDCT with breast and cervical lymph-node involvement is reported in this paper. To our knowledge, this is the first case of IDCT originating from the breast. In the breast and lymph node, the tumor displayed diffuse sheets, fascicles and storiform growth pattern. It was composed of oval to spindle cells with pale to eosinophilic cytoplasm, ill-defined cell outlines, oval nuclei with vesicular chromatin and prominent eosinophilic nucleoli. Mitotic activity was three per ten high-power fields. The neoplastic cells were intermingled with small mature lymphocytes and plasma cells. Immunohistochemical studies showed that the tumor cells were strongly and diffusely positive for vimentin, CD68, S-100 protein, CD45/leukocyte common antigen and fascin and focally positive for lysozyme, alpha-1 antitrypsin and CD4. Ki-67 labeling index was 10%. The patient was treated with combined therapeutic approaches, including surgery, radiotherapy and chemotherapy. IDCT has the potential for an aggressive clinical course. However, 32 months after the initial diagnosis, the patient is still alive and being followed with a stable tumor burden. 相似文献
17.
M. Ishizawa K. Matsumoto S. Kukuda H. Okabe K. Hodohara S. Ota 《Virchows Archiv : an international journal of pathology》1995,427(1):105-110
Two cases of anaplastic large cell Ki-1 lymphoma involving bone as the most prominent and initial manifestation are reported. The first patient was a 20-year-old male who had back pain and incomplete paraparesis due to vertebral involvement. The second was a 14-year-old girl, whose first clinical signs were fever of unknown origin and sternal bone pain. Radiologically, skeletal lesions were lytic and destructive. Histopathologically, the tumour cells had pleomorphic bizarre nuclei and abundant basophilic cytoplasm. Immunohistochemically, Ki-1 (CD30) reactivity was strongly positive in both cases. Tumour cells were also CD3, CD4, epithelial membrane antigen and interleukin-2 receptor positive in the first case, and CD10, HLA-DR positive in the second case. The former tumour was considered to be of T-cell lineage and the latter of lymphoid progenitor cell origin. Radiation and chemotherapy were temporarily effective. However, both patients died 14 and 7 months after diagnosis, respectively, due to systemic lymph node involvement. These observations suggest that the prognosis for Ki-1 lymphoma involving bone is poorer than indicated in previous reports. 相似文献
18.
冷冻同种异体骨段移植修复股骨近段大块骨缺损 总被引:1,自引:0,他引:1
为观察大块冷冻同种异体骨移植后免疫功能的改变及预后,对13例恶性骨肿瘤瘤段切除后的骨缺损10.8~19.4cm(平均为14.6cm),分别采用冻冷异体松质骨段移植的髋关节加压融合术(6例)和异体股骨近段半关节移植成形术(7例)修复.10例分别于术前4天及术后14和28天检测其空腹外周血各项免疫学指标,以及术后3、6、9、12、24、48个月进行99mSPECT骨扫描(5例)和X-线片检查(12例),以观察宿主的免疫反应和异体骨愈合情况.结果:①外周血T淋巴细胞亚群(OKT3+,OKT4+,OKT8+)及血清补体(C3,C4)和循环免疫复合物(CiC)手术前后比较无显著性差异(P>0.05).②99mTe SPECT骨扫描显示:术后3~6个月移植的异体骨两端及髓腔内同位素浓集明显低于正常,而异体骨两端所对应的自体骨端同位素浓集明显高于正常,此现象于植入后9个月开始减弱,可达数年.X线片显示:异体骨愈合率为92.3%(12/13),2例移植的异体松质骨段于术后4~6年完全成活替代.以上可见:①冻冷异体骨段移植后宿主的全身免疫机能改变不明显,其反应是以局部炎症为主的细胞免疫过程;②异体骨可做为修复大块骨缺损的良好材料. 相似文献
19.
S. Riedl H.-J. Buhr Ch. Herfarth 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1994,379(1):38-43
27 patients with pancreatic and 8 with duodenal injuries were studied, 66% of whom had associated abdominal injuries. Peritoneal lavage was performed in 10 cases, and ultrasonography in 15. Laparotomy was considered to be indicated on the basis of the results in 9 cases of peritoneal lavage and in 12 cases of ultrasound examination, but in only 1 case and 2 cases, respectively, did the findings constitute the only reason for performing a laparotomy. Pancreatic and duodenal injuries were directly confirmed by ultrasonography and computer tomography only in a minority of cases. The morbiditiy of pancreatic and duodenal injuries was 66% and 25%, respectively, and lethality, 19% and 25%. Despite modern imaging techniques, clinical examination is of paramount importance for the decision as to whether operative therapy is indicated; delay leads to increased morbidity and lethality. 相似文献
20.
Prof. Dr. K.-H. Schultheis S. Ruckriegel C. Gebhardt 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1994,379(1):20-25
Zusammenfassung Berichtet wird über die operative Behandlung von 1232 Patienten mit einem kolorektalen Karzinom aus dem Zeitraum 1.09.1984 bis 1.01.1990. Entsprechend einer Resektionsquote von 90,3 % wurden 1112 Patienten (kurativ: n = 917, palliativ: n = 195) reseziert. Bei 82 Patienten war wegen Organüberschreitung des Tumors eine multiviszerale Resektion von einem oder mehreren benachbarten Organen (69mal kurativ, 13mal palliativ) notwendig. Komplikationsraten (26,7% zu 27,5 %) und die 30-Tageletalität (3,4% zu 2,9 %) waren in beiden Gruppen der kurativ and kurativ erweitert resezierten Patienten gleich. Die Berechnung der Fünfjahresüberlebensrate ergab für die kurativ resezierten Patienten ohne Erweiterung einen Wert von 58% gegenüber 55 mit Erweiterung. Auch die Subgruppenanalyse ergab keinen Unterschied in den einzelnen Stadien. Die Ergebnisse lassen den Schlul zu, da bei gleicher Komplikations-und Letalitätsrate die kurativ erweiterte Resektion von pT3- and pT4-Tumoren gleiche Spdtergebnisse wie die entsprechende Behandlung von nicht erweitert resezierten pT3-Tumoren erwarten lät. Die Daten zeigen, da eine Infiltration von Nachbarorganen durch ein kolorektales Karzinom nicht als Inoperabilitätskriterium gelten darf.
From 1 September to 1 January 1990, a total of 1232 patients underwent surgery for colorectal cancer. Resection was performed on 1112 (90.3%) patients. It was curative in 917 cases and palliative in 195. Multivisceral resection was necessary 82 times because of tumour infiltration of adjacent organs (curative: 69 cases; palliative: 13 cases). The complication rate (26.7% vs 27.5%) and mortality rate (3.4% vs 2.9%) were similar to those for curative resections without multivisceral extension. The 5-year survival rate was also similar in the two groups (58% vs 55%). These results show that curative multivisceral resections can lead to the same long-term results as conventional curative resections. These data are encouraging, and tumour infiltration of neighbouring organs should not be taken to demonstrate inoperability.相似文献