首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   2279篇
  免费   149篇
  国内免费   53篇
耳鼻咽喉   5篇
儿科学   49篇
妇产科学   84篇
基础医学   162篇
口腔科学   24篇
临床医学   359篇
内科学   453篇
皮肤病学   57篇
神经病学   129篇
特种医学   19篇
外科学   160篇
综合类   103篇
预防医学   98篇
眼科学   19篇
药学   269篇
  1篇
中国医学   95篇
肿瘤学   395篇
  2024年   7篇
  2023年   80篇
  2022年   130篇
  2021年   149篇
  2020年   137篇
  2019年   182篇
  2018年   139篇
  2017年   143篇
  2016年   120篇
  2015年   101篇
  2014年   182篇
  2013年   303篇
  2012年   107篇
  2011年   120篇
  2010年   64篇
  2009年   82篇
  2008年   79篇
  2007年   66篇
  2006年   61篇
  2005年   50篇
  2004年   34篇
  2003年   35篇
  2002年   31篇
  2001年   15篇
  2000年   13篇
  1999年   16篇
  1998年   10篇
  1997年   4篇
  1996年   1篇
  1995年   4篇
  1994年   2篇
  1993年   1篇
  1992年   2篇
  1991年   1篇
  1990年   1篇
  1989年   1篇
  1987年   1篇
  1986年   1篇
  1985年   2篇
  1983年   2篇
  1981年   1篇
  1971年   1篇
排序方式: 共有2481条查询结果,搜索用时 15 毫秒
91.
Changing concepts in the surgical management of renal cell carcinoma   总被引:8,自引:0,他引:8  
  相似文献   
92.
To address child trauma caused by events that affect children directly, such as abuse, or indirectly, such as divorce, creative arts therapies are used by creative arts therapists as well as psychologists and counselors. The purpose of this paper is to review such interventions and the research conducted throughout the last 12 years. We considered the methodology used, the population under study and theoretical frameworks, with specific attention given to the reliability, validity and trustworthiness of such research findings. The results showed that the majority of articles reported their findings narratively, with much emphasis placed on the process followed. It was recommended that therapists work closely with researchers to make creative arts therapies less of an outlier in the therapeutic approaches for traumatized children.  相似文献   
93.
PurposeTo summarize the Society of Interventional Radiology Foundation’s Research Consensus Panel development of a research agenda on prostate artery embolization (PAE).Materials and MethodsPAE for the treatment of lower urinary tract symptoms has been shown to be safe and effective in decreasing symptoms and prostate size. Lack of randomized controlled trials (RCTs) on PAE in the United States has prevented inclusion in American Urologic Association guideline recommendations for treatment of lower urinary tract symptoms resulting from benign prostatic hyperplasia. Recognizing the need for well-designed trials, the SIR Foundation funded a Research Consensus Panel to prioritize a research agenda. The panel included interventional radiologists, urologists, SIR Foundation leadership, and industry representatives. The goal of the meeting was to discuss weaknesses with current data and study design for development of US trials to report long-term outcomes data.ResultsFinal consensus on a research design could not be made because the group was split on 3 research designs: (i) RCT of PAE versus sham with crossover of the sham group. (ii) RCT of PAE versus simple prostatectomy. (iii) RCT of PAE versus holmium laser enucleation of the prostate/thulium laser enucleation of the prostate. The panel recommended a nonindustry-funded registry to obtain real-world data.ConclusionsLevel 1 data are required to be included in the American Urologic Association guidelines for treatment of benign prostatic hyperplasia. Because of concerns with all 3 study designs, the panel did not reach a consensus. Further meetings are planned with the panel to select among these research designs.  相似文献   
94.
95.
96.
97.
The aim of the study was to clarify and build upon current understandings of mental health nurse (MHN) identity. The study adopted a framework of social constructionism and qualitative methodology. Semistructured interviews were conducted, which were thematically analyzed using Nvivo software. Twenty‐five MHN were recruited across three geographical sites in the UK. Participants constructed a cluster of seven MHN identity characteristics that constituted a unique contribution to talk‐based therapies. These themes of characteristics are: (i) the MHN as generic specialist; (ii) the MHN as adopting a service‐user focus; (iii) the MHN as positioning and utilizing the personal self; (iv) the MHN as spending time with the service user; (v) the MHN as delivering talk‐based therapies in versatile ways; (vi) the MHN as having an everyday attitude; and (vii) the MHN as having transferable skills. The distinctiveness, and thus, professional identity of mental health nursing, must be understood as a cluster of capabilities rather than a search for a singular point of difference. The breadth of capabilities employed by MHN highlights the value and worth of their contribution to service‐user care.  相似文献   
98.
BACKGROUND: The oncology community usually perceives phase I oncology trials as associated with poor or limited benefits and substantial risks. There is scarce data concerning outcome and survival of patients enrolled in current phase I oncology trials. PATIENTS AND METHODS: We reviewed all phase I oncology trials conducted by investigators from the Adult Phase I Unit at Institut Gustave Roussy from 2003 to 2006. We report data concerning patient demographics, treatment outcome, toxicity, survival and type of care after trial exit. RESULTS: We analyzed 10 trials involving 180 participants. The overall response rate was 7.2%. Disease control (objective response plus stable disease) was achieved in 48.2% of patients. The rate of toxic death was 0.5%. In all, 38% of patients had at least one episode of grade 3 or 4 toxic events. The median progression-free survival and the median overall survival (OS) were 2.3 and 8.7 months, respectively. On multivariate analysis, a time between diagnosis of disease and inclusion in the phase I trial > or =24 months and evidence of disease control were statistically significant predictors of improved OS. CONCLUSION: Current phase I oncology trials are safe and are associated with clinical benefit in a substantial proportion of patients.  相似文献   
99.
100.
Radiofrequency ablation (RFA) has emerged recently as a promising therapy for extracranial malignancies. This experiment was conducted to explore the potential of RFA for the treatment of brain tumor in a rabbit model with imaging–histological assessment.Eighteen rabbits with intracranially implanted VX2 tumors of 0.9 ± 0.2cm in diameter were divided into two groups. Group A (n=12) was treated with a cooled-tip RFA technique at 30watts for 30–60s. Group B (n=6) received sham operation. The therapeutic efficacy was evaluated by comparing survival rate, magnetic resonance imaging (MRI) and histological findings.All animals in Group B died within one month after tumor implantation (19 ± 2.6 days). Tumor eradication was achieved in 6/12 rabbits (50.0%) in Group A, of which three rabbits survived longer than three months, another three rabbits were found free of viable tumor when sacrificed. Five rabbits suffered from local tumor relapse. One rabbit developed intracranial metastasis to the brain stem despite a complete ablation of the original tumor. Three-month survival rate of RFA treated rabbits was significantly higher (p < 0.05) than that of control rabbits. The typical MRI appearances of the acute RFA lesion consisted of three characteristic concentric zones, which corresponded to central coagulative tissues (Zone A), peripheral hemorrhagic rim (Zone B) and interstitial edema (Zone C) on histology.This study suggests that RFA may become a promising alternative therapy for the treatment of brain tumor. The recognized characters of thermal lesion on MRI and histology may prove valuable in delimitating the ablation range and understanding the biological response of the RFA.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号