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51.
Doi T Abo W Tateno M Hayashi K Hori T Nakada T Fukao T Takahashi Y Terada N 《European journal of pediatrics》2000,159(12):908-911
We investigated the clinical and biochemical characteristics of a 6-year-old Japanese boy with very-long-chain acyl-CoA dehydrogenase
(VLCAD) deficiency. He had hypoketotic hypoglycaemia, exercise- and fasting-induced lethargy, hepatomegaly and cardiomegaly.
Significant laboratory findings included elevated plasma levels of creatine phosphokinase and acyl-carnitine and a fatty liver
at biopsy suggesting a diagnosis of VLCAD deficiency.
Conclusion The diagnosis of very long-chain acyl-CoA dehydrogenase deficiency was supported by the results of acyl-CoA dehydrogenase
activity for C8 and C16 fatty acids in skin fibroblasts from the patient. Treatment with medium chain triglycerides and l-carnitine in the diet improved his hepatomegaly and cardiomegaly.
Received: 17 April 2000 / Accepted: 5 July 2000 相似文献
52.
T. Mahévas D. Gobert M. Gatfossé A. Mekinian O. Fain 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2017,38(3):201-203
Introduction
Hepatic glycogenosis is a rare syndrome, which includes poorly controlled diabetes mellitus, hepatomegaly, delayed puberty, and growth delay. Insulin edema is sometimes associated.Case report
An 18-year-old woman presented with diffuse edema, hepatomegaly, amenorrhea, uncontrolled diabetes, and elevated transaminases and cholestasis. Hepatic ultrasonography and abdominal computed tomographic scan confirmed the hepatomegaly. The liver biopsy showed a massive glycogenosis and the diagnosis of hepatic glycogenosis was confirmed. Too large doses of insulin were responsible of diffuse edema. Diabetes equilibration and diminution of insulin intakes allow correction of this disorder.Conclusion
Excess of insulin can lead to excessive hepatic glycogen storage by activation of glycogenosis enzymes. Biological manifestations consist on elevated liver enzymes and hyperlactatemia. There is a link between administration of high dose of insulin and edema. Hepatic glycogenosis should be suspected when diabetes is uncontrolled and be considered as a differential diagnosis of steatosis. It may be associated and revealed by insulin edema directly related to excessive insulin intakes. 相似文献53.
目的 探讨母鼠人巨细胞病毒(HCMV)感染对胎鼠脑、肺和肝脏的损害情况.方法 将30只10周龄健康昆明鼠按雌雄比1:1配对,分为感染组(20只)和对照组(10只),均雌雄各半.感染组雌鼠妊娠前3 d腹腔内接种1×106半数组织培养感染量病毒悬液0.5 ml,对照组雌鼠分别接种等量的人胚成纤维细胞培养上清液.然后交配受孕并于孕19 d剖宫取出胎鼠.感染组共获胎鼠15只;对照组获得健康胎鼠36只,随机抽取15只纳入本研究.检测胎鼠脑、肺、肝脏组织HC-MV DNA和病理改变并进行病毒分离.两组间计数资料比较用χ2检验.结果 感染组胎鼠病毒分离阳性率分别为:脑73.3%(11/15)、肝脏53.3%(8/15)、肺脏60.0%(9/15);对照组3种组织病毒分离阳性率均为0(P<0.05).感染组胎鼠HCMV DNA阳性率分别为:脑93.3%(14/15)、肝脏93.3%(14/15)、肺脏86.7%(13/15);对照组HCMV DNA阳性率均为0(P<0.05).病理检测结果显示感染组胎鼠的脑、肺、肝脏组织结构损伤严重,可见病毒颗粒.结论 母鼠HCMV感染可以发生垂直传播,导致子鼠脑、肺、肝脏等易感器官损伤. 相似文献
54.
55.
Retrospective evaluation of abdominal ultrasound examinations were made in 36 patients who came to autopsy within 1 month after the ultrasound study. Without knowledge of clinical or autopsy data, two observers made independent determinations of the midhepatic line measurement of the liver on the ultrasound study using supine and left lateral decubitus longitudinal scans. Autopsy determination of hepatomegaly was made using hepatic weight, patient's total body weight, and patient age correlated with pertinent clinical history. Results of the autopsy/ultrasound correlation demonstrated that those livers measuring 13.0 cm or less in the midhepatic line (both supine and left lateral decubitus positions) were normal in 93% of the cases. Similarly, it was demonstrated that when the liver measured 15.5 cm or greater, it was enlarged in 75% of the cases. Used together, these two criteria result in an 87% accuracy rate in determining the presence or absence of hepatomegaly. Approximately 25% of the cases in our study fell into the borderline category of 13.0–15.5 cm. 相似文献
56.
Apolline Imbard Nuria Garcia Segarra Marine Tardieu Pierre Broué Juliette Bouchereau Samia Pichard Hélène Ogier de Baulny Abdelhamid Slama Charlotte Mussini Guy Touati Marie Danjoux Pauline Gaignard Hannes Vogel François Labarthe Manuel Schiff Jean-François Benoist 《Molecular genetics and metabolism》2018,123(4):433-440
Background and objectives
Patients affected with methylmalonic acidemia (MMA) and propionic acidemia (PA) exhibit diverse long-term complications and poor outcome. Liver disease is not a reported complication. The aim of this study was to characterize and extensively evaluate long-term liver involvement in MMA and PA patients.Patients and methods
We first describe four patients who had severe liver involvement during the course of their disease. Histology showed fibrosis and/or cirrhosis in 3 patients. Such liver involvement led us to retrospectively collect liver (clinical, laboratory and ultrasound) data of MMA (N?=?12) or PA patients (N?=?16) from 2003 to 2016.Results
Alpha-fetoprotein (αFP) levels were increased in 8/16 and 3/12 PA and MMA patients, respectively, and tended to increase with age. Moderate and recurrent increase of GGT was observed in 4/16 PA patients and 4/12 MMA patients. Abnormal liver ultrasound with either hepatomegaly and/or hyperechoic liver was observed in 7/9 PA patients and 3/9 MMA patients.Conclusions
These data demonstrate that approximately half of the patients affected by MMA or PA had signs of liver abnormalities. The increase of αFP with age suggests progressive toxicity, which might be due to the metabolites accumulated in PA and MMA. These metabolites (e.g., methylmalonic acid and propionic acid derivatives) have previously been reported to have mitochondrial toxicity; this toxicity is confirmed by the results of histological and biochemical mitochondrial analyses of the liver in two of our MMA patients. In contrast to the moderate clinical, laboratory or ultrasound expression, severe pathological expression was found for three of the 4 patients who underwent liver biopsy, ranging from fibrosis to cirrhosis. These results emphasize the need for detailed liver function evaluation in organic aciduria patients, including liver biopsy when liver disease is suspected.Take home message
MMA and PA patients exhibit long-term liver abnormalities. 相似文献57.
对50例长期饮酒后所致精神障碍患者的B超监测,了解其肝脏超声检查、诊断情况及经住院戒断治疗后的变化。结果,长期饮用高度白酒后形成慢性酒精中毒的患者,肝脏增大者占54%,而且其肝实质有不同程度的脂肪性变声象图。结论,病人经过住院戒酒治疗后,原异常超声声象图有改善,肿大的肝脏可逐渐恢复正常。 相似文献
58.
Vennervald BJ Booth M Butterworth AE Kariuki HC Kadzo H Ireri E Amaganga C Kimani G Kenty L Mwatha J Ouma JH Dunne DW 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2005,99(2):150-160
Evaluating regression of morbidity associated with parasitic infections is an important component of community-based control programmes. We performed an intervention against Schistosoma mansoni infection, focusing on hepatosplenomegaly in the absence of periportal fibrosis, in a cohort of 67 Kenyan children aged 7-18 years from Makueni District, selected on the basis of hepatosplenomegaly detected by ultrasonography. Clinical and ultrasound examinations were conducted annually for three years after treatment, and the source of infection (a river) was regularly treated with molluscicide, thereby severely reducing exposure to schistosomiasis. Malaria transmission was uninterrupted. The prevalence of hard spleens, and the magnitude of clinically assessed splenomegaly along the mid-axillary and mid-clavicular lines decreased monotonically over time, independently of age, whereas clinically measured hepatomegaly along the mid-sternal line and the prevalence of firm livers decreased in an age-specific manner, being more pronounced amongst children aged 14 years or older at enrolment. Ultrasound data were less informative, and did not concur with clinical observations. These results demonstrate that praziquantel treatment reduces hepatosplenomegaly in the absence of exposure to S. mansoni, even with continuing exposure to malaria. The lack of complete resolution of hepatosplenomegaly in most children suggests, among other things, a residual organomegaly attributable to malaria. 相似文献
59.
Mabrut JY Dubois R Pelizzo G Floret D Frappaz D Chappuis JP 《Pediatric surgery international》2000,16(3):219-221
The authors report three cases of stage IV-S neuroblastoma in infants aged 4, 6, and 8 weeks, who despite chemo- and radiotherapy
required surgical intervention to urgently relieve major thoracoabdominal compression secondary to massive hepatomegaly. The
results were successful, with abdominal expansion being achieved by the introduction of a polytetrafluoroethylene prosthesis,
which was removed during the 2nd, 3rd and 7th postoperative month, respectively, after tumor regression. Two children were
in complete remission 32 and 38 months later, the 3rd died after 16 months of tumor progression.
Accepted: 23 February 1999 相似文献
60.
Kalenahalli Jagadishkumar Puja Jain Vaddambal G. Manjunath Lingappa Umesh 《Iranian journal of pediatrics.》2012,22(2):231-236