Effects of diets containing seeds of Garcinia kola (Heckel) on gastric acidity and experimental ulceration in rats

The antiulcerogenic and gastric acid lowering effects of Garcinia kola (Heckel) seeds were investigated in male albino rats. The animals were fed for 2 weeks on normal rat diets but specially composed to contain 25%, 50% and 75% by weight of G. kola. It was observed that G. kola produced a dose-dependent inhibition of gastric acid secretion and indomethacin-induced ulceration. We suggest that this might be due to its acid-lowering effect and increased mucus production among other factors yet to be determined. © 1997 John Wiley & Sons, Ltd.     

糖尿病肾脏病竞争性内源RNA网络构建及潜在中药预测研究

目的 基于生物信息学构建糖尿病肾病（diabetic nephropathy,DN）竞争性内源RNA(competing endogenous RNA,ce RNA)网络，预测治疗DN潜在有效中药。方法 利用GEO数据库与R语言获取DN差异表达长链非编码RNA(differentially expressed lncRNA,DElncRNA)及差异表达信使RNA(differentially expressed mRNA,DEmRNA)，借助miRcode、Target Scan、miRTarBase、mi RDB数据库整合“DElncRNA-微小RNA(microRNA,miRNA)”与“miRNA-DEmRNA”调控关系，通过Cytoscape 3.7.2软件构建ce RNA调控网络，采用Metascape平台分析ce RNA调控网络主要涉及生物过程及信号通路，借助String数据库与Cytoscape 3.7.2软件获取关键基因，并将其映射到Coremine Medical数据库中，预测治疗DN潜在中药，通过TCMSP、PubChem、UniProt、SwissTargetPre...