Telemetry of Programmed and Measured Data in Pacing System Evaluation and Follow-up

Telemetry of programmed and measured data is an important feature of many pacemakers currently used in clinical practice. The ability to receive non-invasive data from the implanted device constitutes a major advantage for the long-term follow-up of the patients and of device performance. There are numerous types of data retrievable via telemetry: parameters of device characteristics (output, battery longevity, impedance, etc), event recorders or counters, event markers, and endocardial electrograms. Ideally, this information should be beneficial in the longitudinal surveilance of modern pacemakers.     

清热中药对大鼠下丘脑组织中AVP含量的影响

选用典型的清热中药黄芩、银花、连翘组成清热方,从体温调节中枢神经介质方面来探讨清热类中药的解热作用机制。实验表明影响体温调节中枢解热介质AVP代谢,增加其含量,从而抑制体温调定点上移是清热中药作用机理之一。     

Recall of medication during pregnancy: Validity and accuracy of an adjusted questionnaire

Objective — To study the validity and accuracy of an adjusted questionnaire on medical drug use during pregnancy eight years after the pregnancy. Methods — The ability of a questionnaire on medication during pregnancy to detect actual use (= sensitivity) was tested against information collected 8 years previously (in 1983–1984) from 473 women with high-risk pregnancies who delivered at the University Hospital Nijmegen, the Netherlands. Results — For separate drug groups, the sensitivity varied between 5% and 91%. The timing of use was recalled moderately well. Although specific questions on drug groups did improve the sensitivity as compared to an earlier questionnaire, the improvement was not enough to make the questionnaire valid. High maternal education, low birth weight, low gestational age and a low 5-min Apgar score were related to better recall. The sensitivity of the questionnaire depended on the behavioural score of the child, implying recall bias. Conclusion — Questionnaire data on drug use during pregnancy obtained eight years after delivery are not a valid source of information.     

The Dodo Bird: Less a Verdict Than an Opportunity

I contend that although the Luborsky et al. findings on the Dodo bird verdict are noteworthy, the methodology on which they are based is significantly delimited. Amplifying Luborsky et al.'s moderate recognition of that delimitation, I propose a qualitative complement to the extant research. I call this complement "amalgamated" qualitative research and propose that it will deepen, clarify, and contextualize Luborsky et al.'s enigmatic findings. Until this amalgam is implemented, therapy research will be relegated to impressions rather than fine-grained illuminations.     

What methods do stakeholders prefer for feeding back performance data: a qualitative study in palliative care.

OBJECTIVE: To investigate the opinions of stakeholders (service commissioners and providers) on how performance data should be presented, in order to develop effective feedback methods to facilitate the use of these data in decision making. DESIGN: A qualitative analysis of semi-structured face-to-face and telephone interviews. League tables and fictional box plots were presented as an illustrative guide. The themes covered in the interviews were the effectiveness of these two feedback formats, their positive and negative characteristics, and ideas for new and improved feedback mechanisms. PARTICIPANTS: Thirty-six stakeholders representing a range of clinical and non-clinical roles within palliative care and the wider health care system across a variety of statutory and non-statutory organizations from London and the West Midlands. RESULTS: Box plots were received more positively than league tables, and qualitative information was considered more appropriate than pictorial feedback. Conventional methods such as league tables and box plots were judged to lack essential information on which important decisions could be based, such as additional contextual information and the methodological assumptions of the instrument. Both feedback methods were considered useful as an impetus to further discussion. There was a consensus that feedback should be constructive and able to be adapted to the organizational realities in which UK health services function. CONCLUSION: Qualitative research was viewed as the right evidence for gaining an understanding of the quality of end of life care. Stakeholders highlighted the importance of the lay perspective, which requires approaches that illuminate the subjective meanings of patient experience.     

应用数据挖掘技术获取周围型肺癌临床和CT诊断规则的初步研究

目的探讨数据挖掘技术对周围型肺癌影像诊断规则提取的价值。方法收集58例经过临床病理证实的周围型肺癌病例,对其临床及CT表现属性进行标准化认定,输入数据库,分别采用自主开发的基于关联规则知识发现程序与通用数据分析工具ROSETTA中的粗糙集约简算法和遗传分类算法对58例周围型肺癌临床及影像学数据进行挖掘对比研究。结果由Johnson’s Algorithm粗糙集约简算法产生诊断规则51条,由ROSETTA遗传分类算法所产生的诊断规则有5千多条,基于关联规则的挖掘算法所产生的诊断规则有123条。这3种不同的数据挖掘方法产生的最重要的诊断规则基本上都将性别、年龄、位置、毛刺、形状、毛玻璃样密度等属性作为诊断周围型肺癌的主要依据。结论数据挖掘技术在医学影像诊断和鉴别诊断中具有潜在的应用价值。     

炎症性肠病患者生存质量与其应对方式和社会支持的相关性

目的探讨炎症性肠病(IBD)患者的生存质量及其与应对方式和社会支持的相关性.方法应用中文IBD问卷(IBDQ)、简明健康调查问卷(SF-36)、简易应对方式问卷、社会支持评定量表对71例IBD患者(IBD组)进行调查,并与103名正常人(对照组)进行比较.结果IBD患者SF-36及各维度评分显著低于对照组(均P＜0.01),积极应对评分亦显著低于对照组(P＜0.01).IBD患者的积极应对和社会支持与其生存质量呈正相关(P＜0.05,P＜0.01),消极应对与生存质量呈负相关(P＜0.05,P＜0.01).结论IBD患者的生存质量水平较低,良好的应对方式和社会支持能提高其生存质量.     

产后抑郁症相关因素调查研究

目的探讨产后抑郁症的相关因素.方法采用分层整群抽样方法,对长沙市4所医院300例产后6周复查的初产妇进行Edinburgh产后抑郁量表与自编问卷调查.结果产后抑郁症的发生率为17.3%;产妇年龄、婚姻状况、教育程度与产后抑郁症无关(均P＞0.05),分娩疼痛承受力、分娩方式、新生儿性别、母婴同室、母乳喂养为产后抑郁症的影响因素(P＜0.05、P＜0.01),且分娩方式是产后抑郁症的危险因素,分娩疼痛承受力与母婴同室是保护因素.结论产后抑郁症发生率较高,其影响因素应引起产科工作人员的重视.