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31.
BACKGROUND: Oxidative stress is associated with the development of several disorders including cardiovascular disease and cancer. Among conditions known to influence oxidative stress, the use of oral contraception (OC) in women has been a matter of ongoing discussion. METHODS: A total of 897 eligible and healthy volunteers were recruited from among the patients of 50 general practitioners participating in the ELAN study (Etude Liégeoise sur les ANtioxydants). A subsample consisting of 209 women aged 40-48 years was studied for a comprehensive oxidative stress status (OSS), including the analysis of antioxidants, trace elements and three markers of oxidative damage to lipids. Among 209 subsample, 49 (23%) were OC users (OCU), 119 (57%) non-contraception users (NCU) and 41 (20%) were intrauterine (hormonal and copper) devices users (IUD). RESULTS: After adjustment for smoking, systolic and diastolic blood pressure and BMI (or waist circumference), a marked and significant increase in lipid peroxides was observed among OCU women when compared with NCU and IUD users. A cut-off value of 660 microM in lipid peroxides allowed the discrimination of OCU from the two other groups. In contrast, no difference was observed in the plasma concentration of both oxidized low-density lipoprotein (LDL) and their related antibodies. The increased level in lipid peroxides was strongly related to higher concentrations of copper (r < 0.84; P < 0.0001, cut-off value 1.2 mg/l). When compared with NCU and IUD users, plasma antioxidant defences were significantly altered in OCU women as shown by lower levels of beta-carotene (decrease of 39%; P < 0.01) and gamma-tocopherol (decrease by 22%; P < 0.01). In contrast, higher concentrations of selenium (increased by 11.8%; P < 0.01) were observed in OCU women. Blood concentrations of vitamin C, alpha-tocopherol and zinc were unaffected by OC use. CONCLUSIONS: The intake of OC significantly increases the lipid peroxidation in women aged 40-48 years. This may represent a potential cardiovascular risk factor for these women.  相似文献   
32.
Résumé Objectif  évaluer l’impact du cycle menstruel sur le seuil de la douleur en réponse a un stimulus électrique chez 23 volontaires sains de sexe féminin avec et sans contraception orale. Méthode  nous avons suivi et comparé l’évolution longitudinale (3x/semaine durant un cycle menstruel complet) du réflexe nociceptif RIII, et du seuil subjectif de la douleur chez 23 volontaires, 13 avec et 10 sans contraception orale. Résultats  les volontaires sans contraception orale tendent a avoir des seuils nociceptif moyens plus bas que les volontaires sous contraception orale lors des phases menstruelle, folliculaire et lutéale. Lors de l’ovulation, cette différence s’accentue encore et devient significative (32.53 [41.03-24.04] vs 25,99 [33.97-18.02] mAmp, p=0.04). Les données de l’évaluation subjective évoluent dans le même sens, sans être toutefois statistiquement significatives et sans nadir pendant l’ovulation. Conclusions  A l’instar des travaux expérimentaux parus sur la question, notre étude conforte l’idée d’un impact du cycle menstruel sur le seuil de la douleur. Bien qu’incomplète cette étude soulève le voile d’une influence des variations hormonales d’une part sur la transmission du message nociceptif au niveau central et d’autre part sur son intégration subjective qui pourrait être dissociée.   相似文献   
33.
After a solid organ transplant, individuals have the capability to maintain a successful pregnancy. However, many posttransplant pregnancies are unintended, thereby posing risks to health. There is a critical need to strengthen patient education regarding safe approaches to conception, general reproductive health, and childbearing capabilities. The complex needs of patients after transplant, including management of graft health and medication regimens, may distract from the usual reproductive care offered to other individuals of childbearing potential. Thorough education about immunosuppressant medications, contraceptive methods, and expected waiting periods before conceiving are essential. Nurses can work with each individual and direct the interprofessional health care team to provide effective, safe, comprehensive, and inclusive reproductive care to patients posttransplant.  相似文献   
34.
In Zimbabwe, adult HIV prevalence is over 25% and acceptable prevention methods are urgently needed. Sixty-eight Zimbabwean women who had completed a barrier-methods study and 34 of their male partners participated in focus group discussions and in-depth interviews to qualitatively explore acceptability of male condoms, female condoms and diaphragms. Most men and about half of women preferred diaphragms because they are female-controlled and do not detract from sexual pleasure or carry stigma. Unknown efficacy and reuse were concerns and some women reported feeling unclean when leaving the diaphragm in for six hours following sex. Nearly half of women and some men preferred male condoms because they are effective and limit women's exposure to semen, although they reportedly detract from sexual pleasure and carry social stigma. Female condoms were least preferred because of obviousness and partial coverage of outer-genitalia that interfered with sexual pleasure.  相似文献   
35.
Teenage pregnancy is a cause and consequence of inequality, limiting the life chances of young parents and their children. It is an issue of global concern, with many countries developing programmes of prevention. This review focuses on the experience of the England strategy, launched in 1999 to address the historically high rates. It is one of the few examples of a successful long term, multi-agency programme, led by national government and locally delivered which, between 1998 and 2018, reduced the under-18 conception rate by 64%. It sets out the case for helping young people delay early pregnancy, the international evidence for prevention, how evidence is translated into a ‘whole system’ approach and the priorities for further reducing inequalities. Questions are included to encourage both investigation into local programmes on teenage pregnancy prevention, and reflection on individual practice. The review concludes with summarizing the next steps for England and the lessons that can be shared more widely.  相似文献   
36.
用生物降解性聚己内酯(PCL)为载体制备女性抗生育药物左炔诺孕酮(LNG)的长效皮下埋植胶囊。除可降解外,该胶囊具有微孔结构,重要技术特征是在PCL中加入固体水溶性大分子PluronicF68(F68)作为致孔剂,研究了加入致孔剂的工艺和微孔形成的原理,用核磁共振和扫描电镜等方法证明在亲水介质中F68很快溶出,形成多微孔结构。体外和动物体内药物释放的研究证明该埋植剂具有零级释放动力学,可在体内长期维持稳定的药物释放量,每根3cm长的埋植剂在体内每天释放约21微克LNG,预期一次植入两根可有效地避孕两年  相似文献   
37.
AIM: To outline the use of contraception among a representative sample of New Zealand women, and explore associations with intimate partner violence (IPV), and contraception and condom use. METHODS: Face-to-face interviews were conducted with a random sample of 2790 women who had ever had sexual intercourse, aged 18-64 years old in two regions (urban and rural) in New Zealand. Analyses were conducted using logistic regression and Wald chi(2) tests. RESULTS: Almost all women had used contraception at some point in their life, and almost one half of all women 18-49 years were currently using methods of contraception. Contraceptive use and methods varied significantly by location. Women who had ever experienced IPV were significantly more likely to report having ever used contraception, compared with women who had not experienced IPV (91% vs 85.2%). While having a partner who refused to use or tried to stop women from using a method of contraception was rare, it was significantly more common among women who had ever experienced IPV (5.4% vs 1.3%). CONCLUSIONS: Most women have used contraception at some point. Women who have ever experienced IPV were: more likely to have used contraception than women who have not experienced IPV, and to have had partners who refused to use condoms or prevented women from using contraception. Partner refusal may be a key indicator of IPV. These findings emphasise the importance of family violence screening at routine health consultations.  相似文献   
38.
目的:探讨多形式健康教育提高青少年性知识的效果。方法:选取本辖区青少年400例为观察组,另选400例青少年为对照组,观察组实施多形式健康教育,对照组接受常规健康教育,对两组青少年的性知识情况、紧急避孕知识进行观察。结果:教育前,两组青少年的性知识了解程度无明显差异(P0.05),观察组青少年经教育后的性知识了解程度明显高于对照组,差异有统计学意义(P0.05);两组青少年教育前的紧急避孕知识知晓率无明显差异(P0.05),观察组教育后的知晓率显著较对照组高,差异有统计学意义(P0.05)。结论:多形式健康教育能提高青少年的性知识了解程度,也能提高青少年对紧急避孕知识的知晓率,对降低青少年非意愿妊娠、性传播疾病发生率具有显著作用,值得临床推广。  相似文献   
39.
ObjectivesApproximately 30% of the Tanzanian women in the reproductive age group are iron deficient. At population-level, there is a dearth of research on the relationship between hormonal contraceptive use and iron deficiency. The study objective was to examine the relationship between history of hormonal contraceptive use and iron status among women in Tanzania.Study designWe conducted a cross-sectional study analysis including 4186 women who participated in the population-based 2010 Tanzania Demographic and Health Survey.Main outcome measureIron status determined by iron deficiency, anemia, and iron deficiency anemia.ResultsAlmost 19.0% women reported history of hormonal contraceptive use. Nearly, 30.0%, 39.5%, and 14.3% women had iron deficiency, anemia and iron deficiency anemia respectively. History of hormonal contraceptive use was negatively associated with iron deficiency, anemia and iron deficiency anemia, independent of potential confounders. Compared to non-users, the multivariable-adjusted odds ratio OR (95% CI) among hormonal contraceptive users was 0.73 (0.56–0.94, p < 0.05) for iron deficiency, 0.58 (0.46–0.72, p < 0.001) for anemia, and 0.53 (0.37–0.74; p < 0.001) for iron deficiency anemia. Longer duration of hormonal contraceptive use (>2 years) had lesser odds of iron deficiency 0.63 (0.43–0.91, p for trend 0.005), anemia 0.51 (0.36–0.73, p for trend <0.001) and iron deficiency anemia 0.35 (0.19–0.65, p for trend <0.001).ConclusionOur finding has important implications for educating healthcare providers and women about additional nutritional benefits of the use of hormonal contraceptives.  相似文献   
40.
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