我国生物医药可持续创新政策体系框架研究

创新是经济增长的重要驱动力.依据创新理论和国家创新体系理论的文献研究,结合《国家中长期科学和技术发展规划纲要(2006—2020年)》、《国家创新驱动发展战略纲要》以及联合国2030年可持续发展议程,基于政策工具视角,通过文献研究初步构建我国生物医药可持续创新政策体系的框架模型,经专家意见法确认并完善框架模型.采用文献...     

统计学思想与三型理论在生物医学科研中的应用

在生物医学科研工作中,人们面对的是具有极大变异性的生物体,而研究具有变异性事物或现象的变化规律,离不开统计学的思维方法和技术手段,因此,统计学起着不可替代的作用。遗憾的是统计学的理论比较深奥,要考虑的问题非常多,应用时灵活性又非常大,每当实际工作者(包括科研工作者     

磁性纳米材料在生物医学领域的应用

从靶向药物载体技术,细胞分离技术,免疫分析,酶的吸附与固定作用和基因治疗几个方面简要分析磁性纳米材料在生物医学领域的应用及其发展过程中有待解决的问题。     

Selective patient and public involvement: The promise and perils of pharmaceutical intervention for autism

Background

Guidelines suggest the patient community should be consulted from the outset when designing and implementing basic biomedical research, but such patient communities may include conflicting views. We examined how engagement occurred in one such instance.

Objective

Our objective was to scrutinize patient and public involvement (PPI) by a pan‐European biomedical consortium working to develop drugs to treat autism. We aimed to use this as an example to illustrate how PPI has been utilized in biomedical research.

Setting, participants and analysis

Two public events, one in the UK and one in Denmark were conducted as part of the consortium's on‐going PPI activities in 2014 and 2015. Sixty‐six individuals submitted written comments on the consortium's research after these events. The textual data produced were analysed using a thematic approach. Approximately 71% of respondents reported themselves to be adults on the autism spectrum or parents of children with autism.

Results

The themes identified illustrated major differences between some community concerns and the biomedical research agenda. While treating autism per se. was seen as problematic by some, treating specific co‐occurring problems was seen as helpful in some circumstances. The biomedical consortium selected PPI with a limited user viewpoint at its outset and more widely once basic research was on‐going.

Discussion

This case illustrates what we term “selective PPI” where only a sympathetic and/or limited patient viewpoint is included. Findings highlight the perils of using selective PPI to legitimise scientific endeavours, and the possibilities for constructive dialogue.     

Innovation strategy management survey of the Chilean biomedical industry. Assessment of windows of opportunities to reduce technological gaps

The convergence of different theories (ie, catch‐up effect and windows of opportunities) allows for the interpretation of different “technological innovation gaps” in Chile's biomedical industry. It is common knowledge that Chile has always had an economy almost exclusively based on services, commodities, and mainly in the exploitation of natural resources with low value added. The literature confirms that countries that concentrate their economies on the knowledge, research, development, and commercialization of technology and innovation have a better and more stable growth rate in the medium and long run. The “Asian Tigers” are a good example of this. Analyzing the technological gaps that affect the Chilean biomedical industry, it is possible to find windows of opportunities to catch up. This could allow the country to take its knowledge, skills, and capabilities further, thus enabling Chile to not just depend on its unpredictable natural resources. For the first time, a quantitative diagnosis of the Chilean biomedical industry was made. This study considered the Chilean biomedical industry and its innovation and entrepreneurship environment, taking into account its productive capacities and its potential to make progress in technological innovation and, as a result, dramatically reducing technological gaps through windows of opportunities.     

Pain,suffering and risk

A primary role of medicine is often perceived as treating or alleviating pain, but what actually constitutes pain can be defined in many ways. A major impediment to a more adequate conceptualization of pain is thought to be the manner in which it has been ‘medicalized,’ over the course of the twentieth century resulting in the inevitable Cartesian split between body and mind. Consequently, the dominant conceptualization of pain has focused almost exclusively upon the neurophysiological aspects, both in diagnosis and treatment, with the subsequent inference that it can be rationally and objectively measured. Social science, in particular the sociological literature on chronic illness, offers a framework for understanding the experience of pain by focusing on ‘lived experience,’ including narratives of suffering. Medically, pain is often explained in terms of risk by attempting to measure so-called objective symptoms, whereas accounts of suffering may encompass more easily the notion of total pain (Saunders 1976 Saunders, C. 1976. Care of the dying. Nursing Times, 72: 3–24.  [Google Scholar]), which includes psychological, spiritual, interpersonal and even financial aspects of chronic pain, as well as its physical aspects. This paper proposes that illness narratives and phenomenological accounts have become intrinsic to the understanding and treatment of pain and, using examples from empirical research, considers how pain narratives challenge biomedical approaches to chronic pain, which are inevitably framed in the discourse of risk.     

Psychiatry under Pressure: Reflections on Psychiatry’s Drift Towards a Reductionist Biomedical Conception of Mental Illness

We argue that contemporary psychiatry adopts a defensive strategy vis-à-vis various external sources of pressure. We will identify two of these sources – the plea for individual autonomy and the idea of Managed Care – and explain how they have promoted a strict biomedical conception of disease. The demand for objectivity, however, does not take into account the complexity of mental illness. It ignores that the psychiatrist’s profession is essentially characterized by fragility: fluctuating between scientific reduction and the irreducible complexity of reality. Therefore, the psychiatrist is not in need of hard and fast rules, but of judgment. At the end, we suggest that philosophy could inject some healthy uncertainty within psychiatry in order to restore its fragile identity. Our examples are drawn from the Dutch situation but we are confident that they apply to other countries as well.     

Multi-functional chitosan-based smart hydrogels mediated biomedical application

Introduction: Chitosan as a natural polysaccharide have been widely applied in biomedicine due to their outstanding biodegradability, non-toxic, and low-price. As carriers, the multi-functional chitosan hydrogels can be prepared by physical and chemical modification to form smart hydrogels to release cargoes. The smart hydrogels can generate sol–gel phase transition while gaining stimulus from the environment including pH, temperature, photo, and so forth. In recent years, a variety of therapeutic approaches such as gene therapy, chemotherapy, and combined therapy can be achieved by combining chitosan-based hydrogels with therapeutic agents.

Area covered: This review reports the state-of-the-art progress of chitosan-based hydrogel delivery systems and some new technologies and discusses the smart chitosan hydrogels. In addition, the current trends and the future prospects together with the drawbacks of chitosan hydrogels as biomaterials are also discussed.

Expert opinion: Chitosan as a natural material has been widely studied and reported. Due to its many advantages, the development of chitosan has been applied in all walks of life. However, the application of chitosan hydrogels in disease therapy is limited due to their weak physical and chemical properties in vivo. Thus, it is high likely that chitosan-based hydrogels will contribute to further research and exploration.     

The sociology of cancer: a decade of research

Biomedicine is often presented as the driving force behind improvements in cancer care, with genomics the latest innovation poised to change the meaning, diagnosis, treatment, prevention and lived experience of cancer. Reviewing sociological analyses of a diversity of patient and practitioner experiences and accounts of cancer during the last decade (2007–17), we explore the experiences of, approaches to and understandings of cancer in this period. We identify three key areas of focus: (i) cancer patient experiences and identities; (ii) cancer risk and responsibilities and (iii) bioclinical collectives. We explore these sociological studies of societal and biomedical developments and how sociologists have sought to influence developments in cancer identities, care and research. We end by suggesting that we extend our understanding of innovations in the fields of cancer research to take better account of these wider social and cultural innovations, together with patients, activists' and sociologists' contributions therein.     

SELEX技术及寡核苷酸适配体的近期研究进展

指数富集的配体系统进化（SELEX）技术是一类具备蓬勃发展前景的体外筛选技术,在生物学、药学及化学领域已引起广泛关注。本文即针对2004年以来SELEX技术的发展特点,主要介绍两类新型SELEX策略,即毛细管电泳-SELEX和针对复杂靶标的SELEX方法,并简要总结了寡核苷酸适配体在生物医学和药学相关方面的最新应用进展。