血清脂联素和C反应蛋白与高血压前期的相关性研究

目的 探讨血清脂联素（adiponectin,APN）和C-反应蛋白（CRP）与高血压前期的相关性.方法 入选120例体检人群,根据血压水平分为理想血压组（40例）、高血压前期组（42例）、高血压组（38例）,分别测定APN和CRP.结果 APN水平高血压组〈高血压前期组〈理想血压组（P＜0.05）,CRP水平高血压组〉高血压前期组〉理想血压组（ P＜0.05）;APN与CRP成负相关,其相关系数（r）为-0.322（ P〈0.05）.结论 血清APN和CRP的水平变化与高血压前期密切相关,可能是高血压前期的独立危险因素.     

老年高血压前期人群多代谢异常分析

目的了解老年高血压前期人群伴随的多代谢异常情况。方法将2008年1月—2011年1月入院的1200例患者按血压水平分为3组:正常血压组(400例)、高血压前期组(400例)、高血压组(400例),分析3组的多代谢异常情况。结果 (1)3组间比较,除饮酒史无差异外,性别(男/女)、年龄、吸烟史、高血压家族史、腰围(WC)、体质量指数(BMI)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)等指标比较,高血压组高于高血压前期组高于正常血压组,而高密度脂蛋白胆固醇(HDL-C)则高血压组低于高血压前期组低于正常血压组,差异均有统计学意义(P<0.05或P<0.01)。(2)TG是高血压前期代谢异常中联系强度最大的一项指标,WC、BMI、FPG、TC、LDL-C、HDL-C等均是高血压前期的危险因素(OR均>1)。结论老年高血压前期人群伴有多代谢异常,TG是高血压前期的主要危险因子。     

高血压前期的流行病学研究进展

本文介绍高血压前期的定义,就国内外高血压前期的流行病学研究进展和争论焦点做了简要综述,并对高血压前期的研究前景进行了展望。     

阿托伐他汀对高血脂合并高血压前期血压的影响

目的观察口服阿托伐他汀在调脂同时对高血压前期青年男性患者血压的影响。方法将经体检发现的63例合并高血脂的高血压前期的青年男性患者随机分为治疗组和对照组。治疗组进行12周阿托伐他汀药物干预性治疗,并与对照组对比观察血脂、血压变化情况。结果随访前两组一般情况对比没有明显差异。12周后,治疗组与治疗前对比舒张压（P〈0．01）、总胆固醇水平（TC,P〈0．01）、低密度脂蛋白-胆固醇（LDL—C,P〈0．01）均有明显下降;与对照组比较,收缩压（P〈0．05）、舒张压（P〈0．01）、TC（P〈0．01）、LDL—C（P〈0．01）也有显著的下降。结论口服阿托伐他汀药物在有效调脂的同时,可以明显降低高血压前期青年患者的血压尤其是舒张期血压。     

安徽省中部地区职业人群血压正常高值状况及危险因素分析

目的了解安徽省中部地区职业人群血压正常高值状况及相关危险因素。方法选取2008年8月在安徽省立医院健康体检中心体检的所有企事业单位(41家)职工2089人,实际研究对象2019人。测量血压、身高、体重、心率、血糖及血脂等,并进行个人既往血压史、生活饮食及饮酒等情况问卷调查。结果该地区职业人群血压正常高值检出率为30.3%。其中男性检出率为34.3%,随年龄增长呈下降趋势,女性为22.5%,在60岁前随年龄增长呈递增趋势,男女性检出率差别有统计学意义(P0.001)。多因素Logistic回归分析显示,与血压正常高值有关的危险因素是:年龄(OR=1.023,95%CI:1.010～1.035),男性(OR=2.992,95%CI:2.223～4.027),心率(OR=1.044,95%CI:1.030～1.057),超重及肥胖(OR=2.523,95%CI:1.867～3.408)。结论安徽中部地区职业人群血压正常高值率接近全国平均水平,存在多种危险因素,应积极控制体重。     

Evaluation of prehypertension and masked hypertension rate among clinically normotensive patients

Background: The present cross-sectional study was aimed to identify pre-hypertension and masked hypertension rate in clinically normotensive adults in relation to socio-demographic, clinical and laboratory parameters. Methods: A total of 161 clinically normotensive adults with office blood pressure (OBP) <140/90?mmHg without medication were included in this single-center cross-sectional study. OBP, home BP (HBP) recordings and ambulatory BP monitoring (ABPM) were used to identify rates of true normotensives, true pre-hypertensives and masked hypertensives. Data on sociodemographic and clinical characteristics were collected in each subject and evaluated with respect to true normotensive vs. pre-hypertensive patients with masked hypertension or true pre-hypertensive. Target organ damage (TOD) was evaluated in masked hypertensives based on laboratory investigation. Results: Masked hypertension was identified in 8.7% of clinically normotensives. Alcohol consumption was significantly more common in masked hypertension than in true pre-hypertension (28.6 vs. 0.0%, p?=?0.020) with risk ratio of 2.7 (95% CI 1.7–4.4). Patients with true pre-hypertension and masked hypertension had significantly higher values for body mass index, waist circumference, systolic and diastolic OBP and HBP (p?<?0.05 for each) compared to true normotensive subjects. ABPM revealed significantly higher values for day-time and night-time systolic and diastolic BP (p?=?0.002 for night-time diastolic BP, p?<?0.001 for others) in masked hypertension than true pre-hypertension. Conclusions: Given that the associations of pre-hypertension with TOD might be attributable to the high prevalence of insidious presentation of masked hypertension among pre-hypertensive individuals, ABPM seems helpful in early identification and management of masked hypertension in the pre-hypertensive population.     

正常高值血压对糖尿病患者微量白蛋白尿的影响

目的：探讨正常高值血压对糖尿病患者微量白蛋白尿（MAU）的影响。方法：对到本院就诊的已排除高血压的糖尿病患者进行尿蛋白/尿肌酐（UACR）测定，筛选出符合30 mg/g≤UACR≤300 mg/g的患者202例，其中正常高值血压组86例，正常血压组116例，分析两组UACR差异。结果：正常高值血压组UACR显著高于正常血压组，差异有统计学意义（χ2=20.087，P〈0.01）。Logistic回归分析显示，正常高值血压与糖尿病MAU呈独立相关。结论：正常高值血压是糖尿病性MAU的独立危险因素之一。     

高血压前期人群中代谢综合征发生情况

目的研究高血压前期人群中代谢综合征(MS)的发生情况。方法依据2006-2007年开滦集团公司职工体检数据库,选取符合美国预防、检测、评估与治疗高血压全国联合委员会第7次报告(JNC7)高血压前期诊断标准的患者33 913例作为高血压前期组,其中男27 213例,女6700例,年龄19～95岁。以数据库中血压<120/80 mm Hg且不符合排除标准者17 961例作为理想血压组,其中男12 218例,女5743例,年龄18～96(46.6±12.8)岁。MS采用国际糖尿病联盟诊断标准。结果①高血压前期组中,男性MS的发生率为14.1%,女性为19.7%。理想血压组MS的发生率男性为4.5%,女性为5.6%。②高血压前期组中无论男女,MS的发生率随年龄的增长而升高,≤29岁组及30～39岁组男性发生率高于女性,40～49岁及其≥49组女性高于男性。结论高血压前期人群中MS的发生率男性为14.1%、女性为19.7%,高于理想血压人群。     

300例高血压前期患者中医体质与动脉硬化程度的相关性研究

目的：探讨高血压前期人群中医体质与动脉硬化程度的改变的相关性。方法：收集高血压前期、高血压、正常血压者各300例为研究对象，对研究对象进行中医体质测评和动脉硬化检测，观察不同体质类型高血压前期人群的动脉硬化程度的改变。结果：双侧肱踝脉搏波传导速度(Brachial Ankle Pulse Wave Velocity，BaPWV)与踝臂指数(Ankle Brachial Index，ABI)呈上升趋势，高血压前期组比正常血压组高(P<0.05)，与高血压组的差异无统计学意义(P>0.05)。3组的动脉硬度相比较，差异有统计学意义(P=0.000)。动脉轻度硬化及动脉硬化的比例呈上升趋势。阴虚质、痰湿质及瘀血质为高血压前期人群动脉硬化的危险因素。结论：高血压前期患者BaPWV明显升高，提示有早期动脉硬度改变;高血压前期患者的动脉硬化程度与阴虚质、痰湿质及瘀血质相关。     

Effect of electro-acupuncture on gene expression in heart of rats with stress-induced pre-hypertension based on gene chip technology

OBJECTIVE:To explore electro-acupuncture's(EA's)effect on gene expression in heart of rats with stress-induced pre-hypertension and try to reveal its biological mechanism based on gene chip technology.METHODS:Twenty-seven Wistar male rats were randomly divided into 3 groups.The stress-induced hypertensive rat model was prepared by electric foot-shocks combined with generated noise.Molding cycle lasted for 14 days and EA intervene was applied on rats in model + EA group during model preparation.Rat Gene 2.0 Sense Target Array technology was used for the determination of gene expression profiles and the screened key genes were verified by real-time quantitative polymerase chain reaction(RT-PCR) method.RESULTS:Compared with blank control group,390 genes were changed in model group;compared with model control group,330 genes were changed in model + EA group.Significance analysis of gene function showed that the differentially expressed genes are those involved in biological process,molecular function and cellular components.RT-PCR result of the screened key genes is consistent with that of gene chip test.CONCLUTION:EA could significantly lower blood pressure of stress-induced pre-hypertension rats and affect its gene expression profile in heart.Genes that related to the contraction of vascular smooth muscle may be involved in EA's anti-hypertensive mechanism.