Caffeine and caffeinated beverage consumption and fecundability in a preconception cohort

Caffeine is an adenosine receptor antagonist that may influence fertility by affecting ovulation, menstrual characteristics, or sperm quality. We studied the association between female and male preconception caffeine intake and fecundability in a North American prospective cohort study of 2135 pregnancy planners. Frequency of caffeinated beverage intake was self-reported at baseline. Outcome data were updated every 8 weeks until reported pregnancy; censoring occurred at 12 months. Adjusted fecundability ratios (FR) and 95% confidence intervals (CI) were estimated using proportional probabilities regression. Total caffeine intake among males, but not females, was associated with fecundability (FR for ≥300 vs. <100 mg/day caffeine among males = 0.72, 95% CI = 0.54–0.96), although the association was not monotonic. With respect to individual beverages, caffeinated tea intake was associated with slight reductions in fecundability among females, and caffeinated soda and energy drink intake were associated with reduced fecundability among males.     

广州市免费孕前优生健康检查服务满意度的快速评价研究

目的探讨广州市接受免费孕前优生健康检查服务的育龄妇女对该项服务的满意度及提供检查服务人员对开展该项检查的认同感。方法采用批质量保证抽样法（LQAS）,选择2013年9~12月,于广州市25家开展免费孕前优生健康检查的定点服务机构中,接受免费孕前优生健康检查的250名育龄妇女,25名医护人员及这些机构所在街、镇的25名计划生育管理人员为调查研究对象。采用自行定制的服务满意度7项评价指标,包括方便性、全面性、解释交流、服务态度、服务技术、服务效率及总体满意情况,通过快速评价法（RAP）,分析接受免费孕前优生健康检查服务的育龄妇女对该项服务的满意度及提供检查的服务人员对开展该项检查的认同感,采用多元线性回归法分析满意度与7项评价指标的相关性。本研究遵循的程序符合上述25家机构人体试验委员会制定的伦理学标准,得到该委员会批准,征得受试对象知情同意,并与之签署临床研究知情同意书。结果 1250名被调查育龄妇女获取免费孕前检查信息的最早知晓途径前3位依次为＂居委会工作者＂42.8%（107/250）,＂宣传栏、折页＂21.2%（53/250）及＂朋友、家人＂12.8%（32/250）;对免费孕前优生健康检查的总体平均满意率为69.4%,满意率前3位指标依次为方便性82.0%（205/250）,服务技术76.0%（190/250）,解释交流74.0%（185/250）;总体平均满意率主要与方便性、服务技术和解释交流3项指标呈正相关（r=0.625,0.335,0.248;P〈0.01）。250名提供检查的服务人员认同开展免费孕前检查的优势主要为＂经费有保障＂94.0%（47/50）,障碍主要为＂群众保健意识差＂74.0%（37/50）,推广免费孕前检查最需解决的问题主要为＂加大宣传,提高群众保健意识＂76.0%（38/50）。结论广州市免费孕前优生健康检查服务满意度存在一定提升空间,应重视孕前检查的风险评?     

Current attitudes and preconceptions towards expanded carrier screening in the Eastern Chinese reproductive-aged population

PurposeA growing number of Chinese individuals of reproductive age will face the choice of accepting or refusing expanded carrier screening (ECS). This study aimed to explore the awareness, wishes, and possible misconceptions of ECS among this population, as well as factors affecting their decision-making.MethodsChinese reproductive-aged individuals in Eastern China who sought cell-free fetal DNA screening and peripheral blood karyotype were invited to complete a 31-item ECS survey by scanning a specific quick response code. We evaluated the relationship between awareness, attitudes, and intentions to participate in ECS, along with possible misconceptions.ResultsOverall, 93.1% of participants intended to undergo ECS at their expenses, and 53.6% indicated they would pay less than 1000 CNY (approximately 145 USD) for the test. Around 96.5% of participants had misconceptions about ECS and genetic diseases. Participants whose first reaction was interest, who had prior awareness of the test, or who perceived benefits were more likely to intend to use ECS (p < 0.001). Participants with a bachelor’s degree or above or with a household income over 150,000 CNY (approximately 21,700 USD) would be more likely to pay ≥ 1000 CNY (p < 0.05).ConclusionsOur study indicates that overall, the Eastern Chinese reproductive-aged population has positive attitudes towards ECS, although there are some misconceptions about ECS and genetic disorders. Population-based ECS appears to be desired by the reproductive-aged people in Eastern China. Steps should be taken to offer ECS along with pre- and post-test education and genetic counseling to raise awareness and to reduce misconceptions.Supplementary InformationThe online version contains supplementary material available at 10.1007/s10815-020-02032-w.     

免费孕前优生健康检查项目规范化实验室建设及人员培训探讨

目的:探讨快速有效提高基层实验室检验质量和管理水平的人员培训方法。方法:通过调研了解重庆市下属区县计划生育技术服务机构的人员专业素质结构、开展检验项目、仪器试剂等情况,有针对性地编写教材、举办理论和操作培训班;制定规范化实验室核查表;进行现场核查和指导、检验结果的一致性比对等。结果:通过对多次培训情况及现场检查和指导情况进行统计分析,培训后"孕优"检验人员的理论考评成绩较培训前显著提高;实验室规范化建设逐年增强。结论:通过调研-培训-现场检查指导-再培训-现场检查指导的循环模式,能快速提高基层实验室检验人员的理论水平和操作技能,并有效促进基层计划生育技术服务机构实验室规范化质量体系建设。     

甲状腺功能检查在孕前检查中的意义

目的通过对计划妊娠妇女孕前疾病检出情况及甲状腺功能情况的分析,了解育龄期妇女甲状腺疾病的发生率及类型,以重视甲状腺功能检查在孕前检查中的意义。方法对324例计划妊娠的妇女进行常规孕前疾病检查及甲状腺功能测定。结果检出疾病排第一位的是妇科疾病,其次为甲状腺功能异常。在甲状腺功能异常这部分人群中大部分为亚临床甲状腺功能减退者。结论由于育龄期妇女甲状腺疾病发病率增加,并且甲状腺功能异常将导致不良妊娠结局发生,针对计划妊娠妇女应将甲状腺功能检查设定为孕前常规检查项目。     

The impact of self-reported preconception body mass index on gestational abnormal glucose tolerance in a Chinese center

Aims

To investigate the association between self-reported preconception body mass index (BMI) and the risk of abnormal glucose tolerance (AGT).