EEG and behavioral profile of flutroline (CP-36,584), a novel antipsychotic drug

The pharmacologic profile of flutroline, a tetrahydro--carboline compound, predicts and antipsychotic compound with greater potency and longer duration than established clinical antipsychotic compounds. In normal male volunteers, it elicited EEG, behavioral, and plasma prolactin release profiles similar to established antipsychotic compounds. Peak activity occurred in 4–5 h. But the clinical activity projected from these studies is one-fifth that of haloperidol. In relation to the available clinical findings, the pharmaco-EEG data are better predictors of the clinical activity of flutroline than its preclinical profile.     

Forensic science service provider models: data-driven support for better delivery options

There are a variety of models for the delivery of forensic science analysis in service to the justice system. In answer to the question as to whether there is a ‘best’ option for the delivery of forensic science services, New Zealand’s Institute of Environmental Science and Research (ESR) has been offered as a model which demonstrates a comparative advantage over the delivery of forensic services in more traditional models. The support for that assertion rests in the ability of the ESR to react at the speed of business and avoid bureaucratic drag found too often in the public sector. This efficiency argument addresses one dimension of the search for ‘best’ delivery. The second dimension involves the discovery of the optimal scale of operation to take efficiency and turn it into cost effectiveness.     

卫生事业管理专业卫生经济学教学案例研究

目的结合中国卫生改革和发展的实际,研究卫生经济教学案例。方法集体备课确定案例需求;通过现有资料收集、以往经验总结及现场调查和访问的形式搜集素材,编写案例;通过教学实践修改完善。结果形成教案、案例集和教学案例使用说明书三个相互衔接的案例教学的材料。讨论有利于提高学生理论联系实际能力,有利于提高教师教学科研能力,仍需不断完善和发展。     

不同厂家雷贝拉唑治疗HP阳性消化性溃疡的疗效与成本-效果分析

目的评价不同厂家雷贝拉唑钠肠溶片三联疗法治疗幽门螺杆菌（HP）消化性溃疡的疗效及成本-效果。方法选择98例近期胃镜下证实为消化性溃疡而且尿素酶HP测试及病理HP阳性的病人,随机分成两组,A组：第1周用国产（瑞波特）雷贝拉唑肠溶片10mg,2次／d,空服,阿莫西林1g、克拉霉素分散片0．5g,2次／d,饭前1h服用,连用7d,以后单用瑞波特10mg,2次／d,空服,连用3周;B组：第1周用进口（波利特）雷贝拉唑肠溶片10mg,2次／d,空服,阿莫西林1g、克拉霉素分散片0．5g,2次／d,饭前1h服用,连用7d,以后单用波利特10mg,2次／d,空服,连用3周;均治疗4周后观察溃疡愈合效果,并用成本-效果分析方法进行药物经济学评价。结果两组治疗前后比较均有明显溃疡愈合效果（P〈0．05）,但组间比较无统计学意义（P〉0．05）;国产雷贝拉唑组效价比更优。结论治疗幽门螺杆菌阳性消化性溃疡国产与进口雷贝拉唑相比,更安全、经济、有效,适合我国国情,值得临床推广使用。     

A Rational Approach to Drug Development: The Confirmatory Phase

A rational approach to drug development would be model-based, target label and knowledge driven where the objective is to characterize the response surface – the interplay of drug regimen/exposure, and patient factors to elicit response (efficacy/safety) – that would result in the right dose for the right patient at the time of marketing the drug. This implies using population PK/PD, knowledge discovery and creation approaches, clinical trial simulation, appropriate surrogate/clinical endpoints, and appropriate statistical analysis for the characterization of the response surface. It also implies interacting with regulatory authorities prior to the initiation of clinical development and throughout the phases of clinical development to ensure that appropriate data to support a new drug application are being generated. To enable further characterization of the response surface in the later phases of development (i.e. phase IIb and beyond) and registration, the confirm–learn aspect of the learn–confirm–learn paradigm of drug development is advocated as the basis for answering the crucial drug development questions – “Is the NCE tolerated and at what dose range?” and “Does it work within the tolerated dose range?”     

不稳定性心绞痛治疗策略的药物经济学评价

国际上有多项有关不稳定性心绞痛与非ST段抬高的心肌梗死保守与介入治疗的大规模临床试验的研文章对试验中治疗策略的成本和疗效进行药物经济学评价。     

江香薷化学成分及药理作用研究进展

对近5年来江香薷的化学成分和药理作用进行概述,江香薷挥发油中酚类化合物含量多,挥发油以外化学成分研究较少。江香薷具有抗菌、杀虫、抗氧化等药理作用,通过一系列的总结为江香薷进一步的研究和开发提供一定的科学依据。