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91.
Jinyi Yuan Biwen Mo Zhuang Ma Yuan Lv Shih-Lung Cheng Yanping Yang Zhaohui Tong Renguang Wu Shenghua Sun Zhaolong Cao Jufang Wu Demei Zhu Liwen Chang Yingyuan Zhang 《Journal of microbiology, immunology, and infection》2019,52(1):35-44
Background/Purpose
Nemonoxacin is a novel nonfluorinated quinolone with excellent in vitro activity against most pathogens in community-acquired pneumonia (CAP), especially Gram-positive isolates. The purpose of this study was to assess the efficacy and safety of nemonoxacin compared with levofloxacin in patients with CAP.Methods
A phase 3, multicenter, randomized (2:1) controlled trial was conducted in adult CAP patients receiving nemonoxacin 500 mg or levofloxacin 500 mg orally once daily for 7–10 days. Clinical, microbiological response and adverse events were assessed. Non-inferiority was determined in terms of clinical cure rate of nemonoxacin compared with that of levofloxacin in a modified intention-to-treat (mITT) population. NCT registration number: NCT01529476.Results
A total of 527 patients were randomized and treated with nemonoxacin (n = 356) or levofloxacin (n = 171). The clinical cure rate at test-of-cure visit was 94.3% (300/318) for nemonoxacin and 93.5% (143/153) for levofloxacin in the mITT population [difference (95% CI), 0.9% (?3.8%, 5.5%)]. The microbiological success rate was 92.1% (105/114) for nemonoxacin and 91.7% (55/60) for levofloxacin in the bacteriological mITT population [difference (95% CI), 0.4% (?8.1%, 9.0%)]. The incidence of adverse events (AEs) was comparable between nemonoxacin (33.1%, 118/356) and levofloxacin (33.3%, 57/171) (P > 0.05).Conclusion
Nemonoxacin 500 mg once daily for 7–10 days is as effective and safe as levofloxacin for treating adult CAP patients in terms of clinical cure rates, microbiological success rates, and safety profile.ClinicalTrials.gov identifier: NCT01529476. 相似文献92.
《The Knee》2021
BackgroundThe cruciate retaining lipped (CR-lipped) bearing is designed to provide more anterior-posterior (AP) stability and could be employed to resolve excessive intraoperative laxity during the cruciate retaining TKA (CR-TKA). The aim of the study was to determine whether the CR-lipped bearing in CR-TKAs with a perioperative excessive laxity allows equivalent functional results as compared to the standard CR articulation.MethodsA cohort of 111 TKAs with CR-lipped bearings was matched to a cohort of conventional CR bearings regarding age and sex. The CR-lipped bearing was used in patients with excessive knee AP laxity and the regular CR bearing was used in patients without excessive AP laxity during TKA. Various PROMs (WOMAC, KSS, SF-36) were assessed preoperatively and at 5-years postoperative in combination with revision rate and Range of Motion (ROM).ResultsPROMs did not differ significantly between both groups 5-years postoperatively. Mean ROM (flexion) 5-years postoperatively was not significantly different. The implant survivorship was 100% for both cohorts with revision for any reason as end point.ConclusionBased on these results, the CR-lipped bearing is a safe and effective solution for mild interoperatively assessed PCL laxity during CR-TKA without loss of function or decreased survivorship at 5 years. Peroperative conversion to a PS-TKA in order to obtain satisfactory functional scores might therefore not be necessary when mild PCL laxity is observed during surgery. Further research should focus on verifying this approach and longer follow-up is needed to generate data on long term survivorship.Level of evidenceLevel IV therapeutic, retrospective, cohort study. 相似文献
93.
M. D. Craggs N. de N. Donaldson P. E. K. Donaldson 《Medical & biological engineering & computing》1986,24(4):424-430
The paper introduces the electrode limit-voltage plane (ELVP)—a useful tool for describing in electrical terms what a polarisable
electrode is doing under a particular set of conditions. The ELVP is then used to consider the charge-injection capability
of a platinum stimulating electrode. 相似文献
94.
潘国良 《中国健康心理学杂志》2007,15(4):363-364
目的 比较阿立哌唑与利培酮治疗精神分裂症的疗效.方法 60例符合CCMD-3精神分裂症患者分为两组各30例,分别予阿立哌唑(A组)和利培酮(B组)治疗6周,采用阳性症状与阴性症状量表及不良反应症状量表评定疗效与副反应.结果 两组疗效及不良反应发生率比较差异无显著性意义.结论 阿立哌唑和利培酮对精神分裂症疗效相当,副反应差异亦不显著;但在锥体外系反应,内分泌改变及体重增加方面,阿立哌唑优于利培酮. 相似文献
95.
D. T. Jobling R. C. Tallis E. M. Sedgwick L. S. Illis 《Medical & biological engineering & computing》1980,18(1):48-56
Patients receiving chronic spinal-cord stimulation in the management of multiple sclerosis have been stimulated at a frequency
of 33 Hz, with pulses whose duration has been varied between 0·05 ms and 2·0 ms. Measurements on the stimulating pulses show
that the energy requirement was at a minimum when the pulse duration was 0·2 ms. The current and energy requirements of different
patients using 0·2 ms pulses vary over a large range but measurement of the current requirement of a particular patient can
be a useful observation in predicting his response to treatment: low current requirements are often associated with a good
response and high currents with a poor response to treatment. The use of 0·2 ms pulses of the amplitude we have used meets
the safety requirements established by other workers and our results indicate that this pulse duration is optimal in terms
of safety requirements, as well as energy requirements. 相似文献
96.
Highly active anti-retroviral therapy (HAART) has reduced the plasma load of HIV-1 to undetectable levels. It has however failed to eliminate the virus from other body compartments. Current methods for monitoring persistent viral replication in HIV-1+ patients require a large amount of blood and/or repeated tissue biopsies. Furthermore, some of the viral reservoirs, such as brain and eye, are inaccessible for sampling. The detection of episomal HIV-1 DNA 2-LTR circles in CD4+ cells is indicative of recent, acute infection events. This paper describes a reliable and reproducible LightCycler-based assay for the quantitative measurement of HIV-1 DNA 2-LTR circles in human peripheral blood mononuclear (PBMN) cells. It details the modifications to the DNA extraction procedure and to the LightCycler PCR procedure that were required to achieve this. This new surrogate marker of persistent viral replication can now be reliably, reproducibly and robustly used to study the clinical progress of large numbers of patients whose plasma HIV-1 RNA has been reduced to undetectable levels by anti-retroviral drugs. 相似文献
97.
《The Knee》2021
BackgroundAs knee osteotomy surgery becomes increasingly accessible, more patients may turn to the Internet for information. This study examined the source, quality, content and readability of online information regarding osteotomy around the knee.MethodsThe first 70 websites returned by the top four search engines were identified using the key words: “knee osteotomy” and “high tibial osteotomy.” The websites were categorised by type and assessed using the DISCERN score, Journal of the American Medical Association (JAMA) benchmark criteria and a novel Knee Osteotomy-Specific Score (KOSS). The presence of the Health On the Net (HON) code accreditation seal was noted. Readability of each website was assessed using eight readability formulae. The mean reading grade level (RGL) was compared to the 6th and 8th grade reading levels. The mean RGL of each category was also compared.ResultsOf the 45 unique websites analysed, the majority were Physician (33%) and Journal websites (31%). The mean DISCERN score was 36.7 (±8.9) which is classified as ‘poor.’ The mean JAMA benchmark criteria score was 2.04 (±1.5) and Physician websites were most likely to be scored zero. The mean KOSS was 15.4 (±5.7). The highest scoring website was a Commercial site but, overall, Journal category sites provided the best quality information. Websites that bore the HONcode seal obtained higher DISCERN, JAMA benchmark criteria and Knee Osteotomy - Specific Scores.The cumulative mean RGL was 13.2 (±2.2) which exceeded the 6th grade level by an average of 7.2 grade levels and the 8th grade level by an average of 5.2 grade levels. No website (0%) was written at or below either the 6th or the 8th grade reading levels. The mean Flesch Reading Ease Score of all websites was 41.13 (±14.7) which is classified as ‘difficult.’ Journal websites had the highest RGL.ConclusionThe information available online regarding osteotomy around the knee varies tremendously in quality and completeness. Physician sites predominate, but these were among the lowest scoring of all websites. Even where high quality information is available, it is set at too high a level to be easily understood.Level of evidenceSurvey of materials – Internet. 相似文献
98.
Kaitlyn Walsh Teaghan A.M. Pryor Kristin A. Reynolds John R. Walker 《Patient education and counseling》2019,102(1):99-105
Objective
The purpose of this study was to evaluate websites providing information on treatment for depression to the public, and to evaluate changes in the quality of website information over time.Methods
Websites (N?=?25) addressing depression treatment were identified through the use of the Google search engine and by suggestions from healthcare professionals. Each website was evaluated based on the extent to which it addressed content areas deemed important by the public identified in previous research, overall quality as determined by the DISCERN, and reading level.Results
Overall, the quality of depression websites varied greatly. The majority of websites did not adequately answer the public’s questions about treatment options, and presented higher quality information in the area of pharmacological treatments as compared to other treatment options. An average reading level of 10.0 was found across websites. Upon re-evaluation, only 14 of 25 websites added new content, and the majority of websites did not improve in their overall website quality (as measured by the DISCERN).Conclusion and Practice Implications
Websites could be improved by addressing important questions that consumers have concerning depression, as well as by creating higher quality content in the areas of psychological, neurotherapeutic, and alternative treatments. 相似文献99.
T. Takaki 《Medical & biological engineering & computing》1988,26(4):397-403
The paper considers the limiting factors in EEG enhancement in the presence of electrosurgery interference and presents a
design for a useful fibre-optic EEG monitoring instrument which is free from such problems as electrical shock (micro and
macroshock), patient burns and susceptibility to electrosurgery interference associated with conventional EEG monitors. 相似文献
100.
M. O. Toll 《Medical & biological engineering & computing》1984,22(1):2-5
The direct measurement of blood pressure has found widespread use in intensive care units, operating rooms, and in emergency
departments. Infection, air embolism and thrombosis are some of the risks to patients associated with both the cannulation
procedure and with the apparatus used in the blood-pressure measuring process. Although there is constant revision in an attempt
to reduce these risks, they cannot be completely eliminated. The need for direct blood-pressure measurements and the physiological
effects of air embolism and thrombosis are reviewed. Infection and problems related to the techniques used to insert the catheters
are not discussed. 相似文献