从一家三甲医院图书馆的发展历程看未来

阐述了北京大学第三医院图书馆的发展初期、专业化发展时期和数字化发展时期3个阶段的不同特点,并以该馆为例,分析了在当今数字化信息服务、移动阅读的环境下医院图书馆所面临的挑战和机遇,提出了充分利用信息技术、改变服务模式与服务内涵、调整服务领域、促进自身的发展、迎接未来的五大发展趋势。即医院图书馆成为医院的文化中心、人工智能的应用前沿、专家型馆员、学科服务决策支持、患者服务。     

用户需求导向的高校图书馆数据素养教育研究

总结了高校图书馆数据素养教育研究现状,分析了高校图书馆用户对数据素养教育的不同需求,从专业馆员与专业教师合作、用户数据素养教育需求调研和分析、构建数据素养教育内容框架和多样化数据素养教育形式等方面提出了用户需求导向的高校图书馆数据素养教育策略。     

医学高校图书馆微视频资源应用策略

分析医学高校图书馆微视频资源建设现状,提出抓帧、切片及批注在医学高校图书馆微视频资源建设中的应用策略,并从应用策略定位和应用场景角度进行深入分析,为进一步完善图书馆资源建设和提升图书馆服务质量提供参考。     

移动医疗服务平台的患者管理机制、效果与风险分析

从时间、空间、信息3个维度剖析了移动医疗服务平台的运作机制,从患者、医生、医院3个角度分析了移动医疗服务平台的患者管理效果和移动医疗服务平台存在的问题与隐患,提出医疗机构应该积极引入并借助移动医疗服务平台实现患者的连续性管理,发挥医生的主观能动性,增强对医生的激励作用等建议。     

Effectiveness of a Smartphone Application as a Support Tool for Patients Undergoing Breast Cancer Chemotherapy: A Randomized Controlled Trial

BackgroundOutpatients undergoing cancer chemotherapy experience anxiety related to adverse drug reactions that they can experience at home. We developed a breast cancer patient support system (BPSS) application (app). The BPSS app chronologically and quantitatively records patients’ subjective and objective symptoms during breast cancer chemotherapy, with the goal of providing supportive management for adverse drug reactions. The present study examined whether the BPSS app is an effective tool for supporting patients undergoing chemotherapy.Patients and MethodsA total of 102 patients undergoing chemotherapy at the Showa University Hospital (Tokyo, Japan) were enrolled in the present order- and age-controlled clinical trial and randomized into BPSS or no-BPSS app groups. The patients underwent 4 courses of chemotherapy. The primary outcome was the change in the hospital anxiety and depression scale score, which was assessed directly before and after the 4 courses of chemotherapy. Other outcomes included health literacy (measured using the 14-item health literacy scale (HLS-14), side effects, and app adherence.ResultsOf the 102 patients, 95 completed the present study. No significant improvement was seen in anxiety, depression, or health literacy at the end of treatment between the BPSS and no-BPSS app groups. Overall, 1868 side effects were reported. When the patients’ records were compared with the medical staff records, the analysis revealed that the medical staff had underestimated some grade 3 symptoms.ConclusionThe BPSS app is a feasible tool for patients with breast cancer and might be useful as a support tool for information sharing between patients and medical staff in an effort to optimize chemotherapy and deliver suitable patient care and support.     

电子病历和HIS接口方案研究

根据电子病历和HIS之间数据交互的实时性和准确性的要求，选择中间库模式作为接口方案，描述了电子处方的工作流程及中间库模式的数据交互，并叙述了中间库模式的关键技术，设计了采用WebService接口的两个关键方法，这对促进两个系统之间的有效集成，提高数据的准确性和一致性、减少医疗事故、提高医疗质量有着十分重要的意义。     

E-health in inflammatory bowel diseases: More challenges than opportunities?

Patients with inflammatory bowel disease need close monitoring for an optimal disease management. For this, e-health technologies are promising tools. But the current evidence for the implementation of e-health in inflammatory bowel disease is weak. For this a critical evaluation of the existing evidence is presented. Furthermore some essential conditions need to be full-filled. We need a robust digital infrastructure that is workable for the patient and the healthcare provider. Important legal issues need to be solved to protect the patient. And the e-health technologies will have to proof their durability, feasibility and acceptance for the patient on the long term.     

医学院图书馆拓展文献提供服务的重要性及途径

在分析文献提供内涵及文献提供现状的基础上,有针对性地根据偏远地区医学院的实际情况、办学特色、发展方向、馆藏理念及人员配备等方面,明确图书馆拓展文献提供服务的重要性及途径,包括强化文献提供意识、积极开发利用网络资源等方面。     

Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history

Most species within the genus Conus are considered to be specialists in their consumption of prey, typically feeding on molluscs, vermiform invertebrates or fish, and employ peptide toxins to immobilize prey. Conus californicus Hinds 1844 atypically utilizes a wide range of food sources from all three groups. Using DNA- and protein-based methods, we analyzed the molecular diversity of C. californicus toxins and detected a correspondingly large number of conotoxin types. We identified cDNAs corresponding to seven known cysteine-frameworks containing over 40 individual inferred peptides. Additionally, we found a new framework (22) with six predicted peptide examples, along with two forms of a new peptide type of unusual length. Analysis of leader sequences allowed assignment to known superfamilies in only half of the cases, and several of these showed a framework that was not in congruence with the identified superfamily. Mass spectrometric examination of chromatographic fractions from whole venom served to identify peptides corresponding to a number of cDNAs, in several cases differing in their degree of posttranslational modification. This suggests differential or incomplete biochemical processing of these peptides. In general, it is difficult to fit conotoxins from C. californicus into established toxin classification schemes. We hypothesize that the novel structural modifications of individual peptides and their encoding genes reflect evolutionary adaptation to prey species of an unusually wide range as well as the large phylogenetic distance between C. californicus and Indo-Pacific species.