个性化正畸牙弓形态计算机辅助设计软件的应用

目的：开发一个实用性的个性化正畸形牙弓形态学计算机辅助设计软件。方法：利用Ｐｅｎｔｉｕｍ３５０、１２８Ｍ计算机,在ＷＩＮＤＯＷＳ９８环境下用Ｂｏｒｌａｎｄ Ｄｅｐｐｈｉ ５．０语言进行研制、开发。结果：该系统具有①牙弓形态的预测以及间隙分析和计算,有利于提高诊断的准确性,治疗方案制定的合理性,以及疗效分析的客观性;②图文并茂的多媒体用户界面,提高了操作的人机互动性,提高了效率和准确性;③运用计算机     

构建中国男性青少年人体静态平衡能力的软件评价平台

以目前平衡能力测试技术、计算机软件编程为平台,构建适合中国男性少年平衡能力的评价体系及配套软件的平台。分别运用因子分析、探索性分析、离差评分等数理统计方法对测试数据进行统计学分析,建立14~18岁男性少年平衡能力评级体系。运用VC++6.0和VC++2005等计算机技术,解决从信息提取、指标细化、分析处理、模块构建、多目标参数融合等一系列关键问题。少年期静态平衡能力评价系统,让人体平衡能力的评价更加方便、更加快捷。     

基于"军字一号"系统的多功能输液卡打印程序的设计与实现

目的 设计基于"军字一号"系统的多功能输液卡打印程序.方法 从"军字一号"数据库提取数据,利用PowerBuilder 9.0开发工具进行程序设计.结果 在原医院信息系统(HIS)下每天打印输液卡基础上,改进为可连续使用7 d,并添加医保类型、液体滴数、频次、抗生素皮试结果和批号、护士查对签名、拔针时间及签名、医嘱停止...     

Neurotoxic injury pathways in differentiated mouse motor neuron-neuroblastoma hybrid (NSC-34D) cells in vitro--limited effect of riluzole on thapsigargin, but not staurosporine, hydrogen peroxide and homocysteine neurotoxicity

The neuroblastoma-spinal motor neuron fusion cell line, NSC-34, in its differentiated form, NSC-34D, permits examining the effects of riluzole, a proven treatment for amyotrophic lateral sclerosis (ALS) on cell death induction by staurosporine (STS), thapsigargin (Thaps), hydrogen peroxide (H₂O₂) and homocysteine (HCy). These neurotoxins, applied exogenously, have mechanisms of action related to the various proposed molecular pathogenetic pathways in ALS and are differentiated from endogenous cell death that is associated with cytoplasmic aggregate formation in motor neurons. Nuclear morphology, caspase-3/7 activation and high content imaging were used to assess toxicity of these neurotoxins with and without co-treatment with riluzole, a benzothiazole compound with multiple pharmacological actions. STS was the most potent neurotoxin at killing NSC-34D cells with a toxic concentration at which 50% of maximal cell death is achieved (TC₅₀ = 0.01 μM), followed by Thaps (TC₅₀ = 0.9 μM) and H₂O₂ (TC₅₀ = 15 μM) with HCy requiring higher concentrations to kill at the same level (TC₅₀ = 2200 μM). Riluzole provided neurorescue with a 20% absolute reduction (47.6% relative reduction) in apoptotic cell death against Thaps-induced NSC-34D cell (p ≤ 0.05), but had no effect on STS-, H₂O₂- and HCy-induced NSC-34D cell death. This effect of riluzole on Thaps induction of cell death was independent of caspase-3/7 activation. Riluzole mitigated a toxin that can cause intracellular calcium dysregulation associated with endoplasmic reticulum (ER) stress but not toxins associated with other cell death mechanisms.     

GE LightSpeed Plus多排螺旋CT故障维修

简单阐述了GELightSpeedPlus多排螺旋CT操作控制台的基本结构组成、工作原理、特点及故障现象,并针对故障进行分析及处理。为拥有该型设备的操作及维修人员提供参考。     

论项目管理在软件项目中的应用

昆明总医院医学工程科自1980年初组建至今已走过30年历程,经过两代医学工程专业技术人员的艰苦努力,经历了＂起步、摸索、创新发展＂三个阶段的实践,实现了全院医疗设备自主维修,创建了拥有多元特色和强大技术、人才优势的品牌学科。     

Tools for consensus analysis of experts’ contours for radiotherapy structure definitions

Background and purpose

To demonstrate and examine the ability of a newly developed software tool to estimate and analyze consensus contours from manually created contours by expert radiation oncologists.

Material and methods

Several statistical methods and a graphical user interface were developed. For evaluation purposes, we used three breast cancer CT scans from the RTOG Breast Cancer Atlas Project. Specific structures were contoured before and after the experts’ consensus panel meeting. Differences in the contours were evaluated qualitatively and quantitatively by the consensus software tool. Estimates of consensus contours were analyzed for the different structures and Dice-similarity and Dice-Jaccard coefficients were used for comparative evaluation.

Results

Based on kappa statistics, highest levels of agreement were seen in the left-breast, lumpectomy, and heart. Significant improvements between pre- and post-consensus contours were seen in delineation of the chestwall and breasts while significant variations were noticed in the supraclavicular and internal mammary nodes. Dice calculations for all pre-consensus STAPLE estimations and final consensus panel structures reached 0.80 or greater for the heart, left/right-breast, case-A lumpectomy, and chestwall.

Conclusions

Using the consensus software tool incorporating STAPLE estimates provided the ability to create contours similar to the ones generated by expert physicians.     

SPECT与CT3D图像异机融合的实验研究

目的:初步探讨SPECT与CT图像异机融合.方法:利用核医学质控PET-CT模型,分别使用SPECT、64排CT、SPECT/CT分别进行采集,然后利用MIPAV软件对SPECT、64排CT图像进行异机融合.以SPECT/CT PET-CT模型同机融合图像为金标准,视觉评价异机融合图像质量.结果:利用M1PAV软件可将SPECT和64排CT所采集PET-CT模型图像较为理想地进行异机融合.由影像科医师对异机融合图像与同机融合图像进行比较,图像质量无显著差异.结论:对于SPECT和CT所采集图像,利用MIPAV软件进行3D图像异机融合具有临床可行性.     

情景模拟软件系统在住院医师培训中的效果评估

目的通过情景模拟软件系统对临床医师进行培训,评价该系统在住院医师临床诊治思维培训中的效果。方法运用情景模拟软件系统,将58名住院医师随机分为未培训组、理论培训组、综合培训组,通过系统自带软件进行考核,对各组参训学员考核成绩运用单因素方差分析进行比较。随后采取调查问卷形式对培训软件进行评价。结果未培训组考核平均成绩为71 ± 13.2分,理论培训组考核平均成绩为85 ± 11.9分,综合培训组考核平均成绩92 ± 7.3分,三组之间均存在统计学差异（P<0.05）,受训医师对培训效果满意度较高。结论通过情景模拟软件系统进行临床思维培训,能够培养临床医师建立正确的临床诊治思维,提高规范化急救能力。