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There were no significant differences in the density (Bmax) of platelet [3H]citalopram binding sites between the two groups. Similarly, the dissociation constant (Kd) values were indistinguishable. The maximum uptake velocity (Vmax) of [3H]5-HT to fresh lymphocytes and the Km values of the 5-HT to the transporter were significantly higher in currently aggressive compared to the non-aggressive schizophrenia patients. The association of high Vmax values with current aggressive behavior provides further support to the involvement of the 5-HTT in aggressive behavior as well as to the efficacy of 5-HTT blockers in the control of aggression. The role of the various components of the serotonergic system in the pathophysiology and treatment of aggressive behavior in schizophrenia needs to be further evaluated. 相似文献
A method to induce microthrombi in small mesenteric vessel (15–25 μm) has been developed to investigate antithrombotic drugs and to study platelet reactions. Mesenteric injuries are induced in the vascular system of Wistar rats with an argon laser. The laser beam induced formation of the vessel wall injury with damage of endothelial cells. Thrombus was formed within seconds after laser injury and grew rapidly. The aggregate can be swept away by the flow and a new thrombus was formed again. This embolization began within the minute following the laser flash. Thrombus formation and embolization were repetitive phenoma. Aspirin (100 mg/kg) and LMWH (1 mg/kg) are approximately the same as to decrease the number of emboli detached from the thrombus and the duration of embolization; both in venules and in arterioles.
This results suggest reflexion about the role of platelets in venous thrombosis induced by laser beam. 相似文献