Polymorphism in the TP63 gene imparts a potential risk for leukemia in the North Indian population

BackgroundThe role of single nucleotide polymorphism rs10937405 (C>T) of the TP63 gene in cancer including leukemia has previously been studied in different world populations; however, the role of this variant in leukemia in the North Indian population of Jammu and Kashmir is still unknown.ObjectivesIn the present study, we investigated the association of genetic variant rs10937405 with leukemic in the Jammu and Kashmir population.MethodsA total of 588 subjects, (188 cases and 400 controls) were recruited for the study. The rs10937405 variant was genotyped by using the real-time based TaqMan assay.ResultsA statistically significant association was observed between the rs10937405 and leukemia [OR of 1.94 (95% CI 1.51–2.48), p=1.2x10–6].ConclusionThe current study concludes that the rs10937405 variant is a risk factor for the development of leukemia in the population of Jammu and Kashmir, North India. However, it would be interesting to explore the contribution of this variant in other cancers as well. Our findings will help in the development of diagnostic markers for leukemia in the studied population and potentially for other North Indian populations.     

微信公众平台在中高职衔接课程中的应用——以外科护理学为例

目的 以外科护理学为例,探究微信公众平台在中高职衔接护理专业高职部分学生中的应用效果.方法 将2018级秋季班学生作为对照组,2019级春季班学生作为观察组,建立"一起学中高外护"微信公众平台,按教学计划给2019级春季班学生推送相关知识链接并及时回复学生提问,比较两个年级学生外科护理学期末理论考试成绩.结果 2019...     

Pedigree likelihood formulae based on founder and founder couple symmetry and validation of DNA testing software

Pedigree likelihood ratios are widely used in forensic genetics. Linkage of genetic markers affects the pedigree likelihood ratio. In this study, a series of novel formulae was established based on simplification due to founder and founder couple symmetry of the Lander-Green algorithm for dealing with linkage. These new formulae are based on the inheritance vectors and differ from existing formulae that are based on the number of alleles shared identical-by-descent. In contrast to previous formulae, the formulae of this study expand the calculation to more general relationships, which enables specifying the number of typed individuals in pedigrees, and the new formulae are no longer limited to calculation of pairs of linked markers. Alternatively, pedigree likelihood values incorporating multiple linked markers could be obtained by iterating the vector transition probability between pairs of linkage markers and the probability of genotypes of typed individuals given inheritance vectors; the vector transition probability formulae are provided in a table form. To demonstrate utilization of the proposed formulae system, a series of cases were designed based on the relationships to validate GeneVisa software (www.genevisa.net) with frequency data of three linked markers, SE33-D6S1043-D6S474, on chromosome 6. The calculation results were verified with the FamLink software. The results demonstrated that the proposed formulae can correctly obtain the pedigree likelihood ratio, demonstrating the application potential of these formulae to verify effectiveness of DNA testing software.     

Racial and Ethnic Disparities in Characteristics and Care Patterns of Chronic Hepatitis B Patients in the United States

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