The effect of hetero- and homosexual experience and long-term treatment with fluoxetine on homosexual behavior in male rats

Introduction The selective serotonin reuptake inhibitors have become the most frequently prescribed drugs for the treatment of depression. Sexual side effects have been noted to occur with this treatment on heterosexual behavior in rats. Heterosexual experience facilitates sexual orientation of male rats and decreases the latencies to first mount and first intromission. On the other hand, homosexual behavior in male rats induced by female hormones has not been evaluated.Aim The objective of this work is to evaluate the effects of heterosexual and homosexual experience in male rats long-term treated with fluoxetine (FLX) on homosexual hormone-induced behavior.Materials and methods Male rats were treated with FLX or saline solution (10 mg/kg for 65 days). At days 36, 50, and 65 of the treatment, the rats were evaluated for homosexual behavior. Other rats treated with FLX or saline solution for 60 consecutive days were submitted to heterosexual behavior at 14, 21, and 28 days of the treatment. After this, they were orquiectomized and homosexual hormone-induced behavior was observed at 45 and 60 days of the treatment.Results (1) Only treatment with FLX did not affect the homosexual behavior. (2) The homosexual experience facilitated the homosexual behavior mainly on the animals from the control group. (3) The heterosexual experience facilitated the homosexual behavior on both groups.Conclusions Only long-term administration of FLX does not interfere with the homosexual behavior in male rats. The homosexual and the heterosexual experience facilitated the homosexual behavior on the control and experimental groups. We suggested that learning aspects related to sexual behavior are responsible by these results.     

中国部分城市2004年1389例男男性接触者艾滋病高危行为及相关因素调查

目的了解中国大陆男男性接触者(MSM)的艾滋病病毒/艾滋病(HIV/AIDS)高危行为及有关影响因素。方法对6大城市1389例MSM采用定向抽样法进行匿名问卷调查和尿液HIV—1抗体检测。应用SPSS 11.0软件对数据资料进行整理分析。结果MSM平均年龄为27.62岁。首次性交年龄平均19.18岁。寻找同性性伴的最主要途径是互联网(43.07%),同性爱者活动场所(35.29%)。近6个月平均同性性伴数为5.69人,平均陌生性伴为4.37人,平均肛交同性性伴为4.33人。曾参与群交者占11.61%。尿液HIV-1抗体初筛检测13例阳性。有肛交史者近6个月内坚持使用安全套者占32.46%,最近一次肛交用过安全套者占76.37%。近6个月曾与女性性交从不用安全套者占47.18%。结论MSM普遍存在易感染HIV的多种高危行为,需加大对该人群的AIDS干预力度,并创造有助于MSM的AIDS控制的支持性环境。