心房颤动患者血浆高密度脂蛋白胆固醇水平变化的临床研究

目的 探讨血浆高密度脂蛋白胆固醇(HDL-C)水平与心房颤动之间的关系.方法 研究对象为135例房颤患者,按能否自行复律分为阵发性房颤组及非阵发性房颤组,并选择同期健康人群30例作为对照组.非阵发性房颤组又分别按左心房内径(LAD＞35 mm,LAD≤35mm)分成亚组,测量所有房颤及正常对照组患者的血浆HDL-C的水...     

运动和限食对肥胖大鼠体脂及血清HDL-C和HL活性的影响

目的：探讨运动和限食干预对食源性肥胖大鼠体脂及血清高密度脂蛋白胆固醇（HDL-C）和肝脂酶（HL）活性的影响。方法：肥胖模型建立后将32只肥胖大鼠随机分为对照组、限食组、运动组、运动＋限食组。各组继续喂食高脂饲料,限食组喂食量为对照组的80%。游泳运动,5周,6 d/周,90 min/d。最后一次运动结束后60 h宰杀大鼠,测量体重、肾脏周围脂肪重量、附睾周围脂肪重量,血清HDL-C浓度和HL活性。结果：（1）对体重降低的影响：限食（P〈0.01）、运动（P〈0.001）有显著作用;运动与限食之间无协同作用（P〉0.05）。（2）对内脏脂肪重量降低的影响：限食无显著影响（P〉0.05）;运动影响作用显著,大鼠肾脏周围脂肪（P〈0.05）和附睾周围脂肪重量（P〈0.01）降低;运动与限食之间无协同作用（P〉0.05）。（3）对于血清HDL-C浓度升高的影响：限食（P〈0.05）、运动（P〈0.01）有显著作用;且运动与限食在大鼠血清HDL-C浓度升高的变化中产生了协同作用（P〈0.01）。（4）对于血清HL活性降低的影响：限食作用不显著（P〉0.05）;运动影响作用显著（P〈0.05）;运动与限食之间无协同作用（P〉0.05）。结论：在不改变膳食结构的前提下,运动和限食能够显著降低肥胖大鼠体重,对内脏脂肪的堆积产生抑制作用,提高肥胖大鼠血清HDL-C浓度同时降低HL活性,降低发生动脉硬化病变的风险。     

One hundred percent orange juice consumption is associated with better diet quality, improved nutrient adequacy, and no increased risk for overweight/obesity in children

The purpose of this study was to examine the association of 100% orange juice (OJ) consumption by children 2 to 18 years of age (n = 7250) participating in the 2003 to 2006 National Health and Nutrition Examination Survey with intakes of select nutrients, MyPyramid food groups, diet quality—measured by the Healthy Eating Index-2005, weight status, and associated risk factors. The National Cancer Institute method was used to estimate the usual intake of 100% OJ consumption, selected nutrients, and MyPyramid food groups. Percentages of the population below the Estimated Average Requirement were determined. Covariate adjusted logistic regression was used to determine if consumers had a lower odds ratio of being overweight or obese. Usual per capita intake of 100% OJ was 1.7 oz/d. Among consumers, the usual intake of 100% OJ for children (n = 2183; 26.2% of population) was 10.2 oz/d. Consumers had higher (P < .05) energy intakes than nonconsumers (9148 ± 113 vs 8625 ± 473 kJ). However, there were no differences in weight or body mass index in consumers and nonconsumers, and there was no significant difference in the risk of being overweight or obese between consumers and nonconsumers (odds ratio, 0.86; 95% confidence interval, 0.70-1.05). Compared with nonconsumers, consumers had a higher (P < .01) percentage (% ± SE) of the population meeting the Estimated Average Requirement for vitamin A (19.6 ± 2.0 vs 30.2 ± 1.4), vitamin C (0.0 ± 0.0 vs 29.2 ± 1.2), folate (1.3 ± 0.3 vs 5.1 ± 0.6), and magnesium (25.5 ± 2.0 vs 39.0 ± 11). The Healthy Eating Index-2005 was significantly (P < .01) higher in consumers (52.4 ± 0.4 vs 48.5 ± 0.3). Consumers also had higher intakes of total fruit, fruit juice, and whole fruit. Moderate consumption of 100% OJ should be encouraged in children as a component of a healthy diet.     

Association of an HDL Apolipoproteomic Score With Coronary Atherosclerosis and Cardiovascular Death

Background

Concentrations of circulating apolipoproteins are strongly linked to risk for coronary artery disease (CAD). The relative importance of the additional knowledge of apolipoprotein concentrations within specific lipoprotein species for CAD risk prediction is limited.

甘油三酯与高密度脂蛋白胆固醇比值和H型高血压的相关性研究

目的 探讨在原发性高血压患者中甘油三酯与高密度脂蛋白胆固醇比值与H型高血压的关系。方法 采取多阶段整群随机抽样的方法,以湖南省6个城市的社区人群作为研究对象。采取问卷调查、体格检查、实验室检查的方式来收集研究对象的资料。采用回归分析的统计学方法分析甘油三酯与高密度脂蛋白胆固醇比值与H型高血压的效应值大小。结果 本研究共纳入1 538名高血压患者,其中H型高血压患者共有1 311人（85.24%）,男性766人（49.80%）。TG/HDL - C与H型高血压的关系呈现倒U型的曲线关系。通过阈值效应分析得出:模型1与模型2的对数似然比检验结果具有统计学意义（P = 0.003）,进一步证实了TG/HDL - C与H型高血压之间是曲线关系。在模型2中可知:在拐点2.22之前,TG/HDL - C每增加一个单位发生H型高血压的风险增加52%（OR = 1.52, 95% CI = 1.16, 2.00, P = 0.002）;在拐点2.22之后,TG/HDL - C每增加一个单位发生H型高血压的风险降低3%（OR = 0.97, 95% CI = 0.90, 1.04, P = 0.401）。结论 在原发性高血压的患者中TG/HDL - C与H型高血压呈现倒U型的曲线关系,并存在饱和阈值效应。     

四物汤对正常动物高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的影响

报道四物场煎液和醇提液作灌胃和皮下注射给药均能明显提高大、小白鼠高密度脂蛋白胆固醇（HDL－C）含量和降低低密度脂蛋白胆固醇（LDL－C）含量。从而提示,四物场不仅能减少胆固醇在肠道的吸收,加速胆固醇在体内的转化,可能还增加高密度脂蛋白（HDL）对血中胆固醇的转运和低密度脂蛋白（LDL）受体对LDL的摄取。从而有减少冠心病和动脉粥样硬化的危险。     

他汀类药物对老老年冠心病患者的应用分析

目的 研究他汀类药物对80岁以上老老年冠心病患者的疗效及安全性.方法 入选73例80岁以上冠心病患者,入院后给予他汀类药物调脂治疗.按他汀药物不同,分为辛伐他汀组（20 mg/d）27例、阿托伐他汀组（20 mg/d）32例和瑞舒伐他汀组（5 mg/d）14例,分别对比分析用药前及随访12～24（13.8±3.7）个月后血脂参数和安全性指标,以及三组患者治疗后各指标的变化.结果 ①冠心病患者治疗后较治疗前TC、LDL-C、LDL-C/HDL-C均有明显下降[（3.59±0.67） mmol/L比（3.84±0.91） mmol/L、（2.16±0.61）mmol/L比（2.39±0.78）mmol/L及（2.15±0.75）比（2.48±0.85）],差异有统计学意义（P＜0.05）;治疗后较治疗前肝功、肾功、肌酶差异无统计学意义.②三组间调脂疗效无显著差异,并且肝功、肾功、肌酶等指标差异无统计学意义.结论 对于80岁以上老老年冠心病患者,应用常规剂量的他汀类药物调脂疗效好,不良反应少,安全性良好.