生物伯德图用于血压稳定性的分析和计算

本文用生物伯德图分析了血压稳定性。按照经典的控制理论,讨论了生物系统的稳定性,提出了血压控制的数学模型。根据生物特点,建立了生物伯德图的表达式。作为系统稳定性的指标,增益裕量和相位裕量可以用作图法求得,也可以用计算机求解。实验结果与理论分析能很好地符合。     

流行性腮腺炎流行病学调查分析与控制对策

目的分析新兴县流行性腮腺炎的流行病学特点，以提供防治参考。方法运用描述性流行病学的统计方法对新兴县2008年报告的腮腺炎病例进行分析。结果新兴县2008年1月至12月共报告流行性腮腺炎23例，年报告发病率为4.98／10万，病例主要集中在流动人口较多的新城镇、太平镇等地区，6月为高发月份，占总发病数26.08％，发病人群主要是10-15岁小学生，占60.86％，腮腺炎相关疫苗免疫史空白和免疫史不详占73.73％。结论加强儿童腮腺炎疫苗的接种工作，重点是流动儿童，发生疫情及时采取综合措施，是控制流行性腮腺炎疫情的重要手段。     

Quality Control in Laboratory Hemostasis and Thrombosis

<正>laboratory equipment,akey to success is not only high quality,complete,technician knowledge,skills,and experiment a clear purpose,select the project has specificity     

内蒙古赤峰地区鼠疫现状和流行趋势预测及控制措施的研究

赤峰地区于１９４８￣１９９６年发现了１６６３２．２ｋｍ＾２鼠疫自然疫源地，分布于１１个旗（县、区）。目前达到控制鼠疫面积１３９１７．８ｋｍ＾２，占疫源地总面积的８３．６８％。选取与疫源地相关的１２种量经因子进行聚类分析，结果可分为：１．疫源性长存区；２．动物鼠疫间断流行区；３．鼠疫动物病控制区；４．疫源性基本消除区。同时对措施进行了探讨。     

革兰氏阴性杆菌发生过程控制的研究

本研究选择奇异变形杆菌和绿肿杆菌等作为实验体系，从群体发生发展过程的宏观表现上探讨了生物控制的时空表达及非线性问题。结果表明，杆菌发生过程的时相周期性可以表现为空间的波形靶图样，并具有分形的特征。实验结果表明，菌群在生长过程中的代谢产物是富含生物信息的控制中介机制。我们认为，生物系统局部存在着准平衡和准封闭的微生态环境，生物液晶的存在和相变是细菌群体发生过程的重要协同中介因素。     

一类“近乎双线性”系统及其稳定化反馈控制

本文定义了一类“近乎双线性”系统。可用以近似一类奇异摄动双线性系统,而且可以描述某些实际工业对象。并发现其控制器的设计较方便。文中还给出了一种简单的反馈控制器的设计方法。又对一类多输入双线性系统,提出一种设计反馈控制器的改进方案,根据Lyapunov定理得到一非线性反馈控制律。以上设计方法分别对某合成氨反应器作了应用研究,仿真结果表明了方法的有效性。     

Cardio-respiratory measures following isocapnic voluntary hyperventilation

In some individuals, breathing is greater than at rest following voluntary hyperventilation. Most previous investigations have employed short hyperventilation periods; here we examine the time course of cardio-respiratory measures before, during, and after a 5-min voluntary hyperventilation, maintaining isocapnia throughout. We examined the possible co-involvement of the cardiovascular system; hypothesising that post-hyperventilation hyperpnoea results from an increase in autonomic arousal. In four subjects (two males, two females) of 18 (nine males, nine females) we observed a post-hyperventilation hyperpnoea, characterised by a slow decline of ventilation toward resting levels with a time constant of 109.0 +/- 16.1s. By contrast, heart rate, and systolic and diastolic blood pressure were unchanged from rest during and after voluntary hyperventilation for all subjects. We concluded that males and females were equally likely to exhibit post-hyperventilation hyperpnoea, and suggest that they may be characterised by an increased resting heart rate and the choice of breathing frequency to increase ventilation during the voluntary hyperventilation. We further concluded that post-hyperventilation hyperpnoea is rare, but when present is a strong and lasting phenomenon, and that it is not the result of an increased autonomic arousal.     

Autoregulation of contractility in the myocardial cell

Summary An investigation was carried out on isolated cat's papillary muscle in order to study displacement effects upon the intensity and the time course of the contractile activity. Displacements occurring before or very early during a contractile cycle produce effects which can be entirely explained on the basis of the cardiac active length-tension relation. Displacements occurring later exhibit additional effects in so far as either stretches or releases induce a drop of contractile activation such that the course of the subsequent tension development is markedly below that of the same displacement applied earlier. In order to separate these effects from those based on the active length-tension correlation experiments were performed in which very short release-stretch or stretch-release operations were applied so that the muscle length was virtually the same at the beginning and at the end of the operation. The results obtained under these conditions can be summarized as follows.The extend to which contractile tension drops after a stretch-release or a release-stretch cycle has been applied depends upon (1) the stimulus intervention interval (2) the length change performed (3) the velocity of displacement during the intervention. It is not dependent on the initial muscle length. Increasing the extracellular Ca-concentration considerably reduces the displacement effects. The results are tentatively explained by assuming an internal feedback loop between a variable of the contractile machinary and the preceding mechanism of activation.This investigation was supported by the Deutsche Forschungsgemeinschaft (grant Ka 287, 1+3).     

消防武警新兵应激性焦虑诱发因素的研究

目的研究探索造成消防武警新兵应激性焦虑的可能社会、文化因素。方法以SAS量表检测筛查某部新兵集训队的所有成员．按相应标准将人群划分为有焦虑症状人群（观察组）和健康人群（对照组），同时调查对比两组人群中造成焦虑的可疑因素暴露情况。结果所观察因素中，是否首次离家独立生活、以前是否经历过火灾现场、是否愿意干消防工作、部队情况与自己期望是否相符和、参军前是否参加过工作．这5项在两组间的暴露情况经统计学处理显示差异有显著性（P〈0．01）。结论可以认为如上结果所示的5项因素的阳性暴露，是造成消防武警新兵进入应激状态出现焦虑症状的主要诱因。     

The role of computational models of the immune system in designing vaccination strategies

Mathematical and computational models are designed to improve our understanding of biological phenomena, to confirm/reject hypotheses, and to find points of intervention by altering the behavior of the studied systems. Here we describe the role of mathematical/computational models of the immune system. In particular, we analyze some examples of how mathematical modeling can contribute to finding optimal vaccination strategies. Indeed, computational modeling offers an intriguing opportunity from the theoretical point of view, and it will be of interest for clinically oriented investigators who wish to find optimal therapeutic strategies and for pharmaceutical industries that want to produce effective and successful drugs.