药物治疗尖锐湿疣127例对比分析

本文分别用三氯醋酸、新洁尔灭及５－氟尿嘧啶治疗１２７例尖锐湿疣，以观察分析其不同疗效。结果三氯醋酸组有效率（９４．４４％）显著高于新洁尔灭组（５５．００％）和５－氟尿嘧啶组（４７．０６％）（Ｐ均＜０．０１），并探讨了该病的病因、治疗、影响疗效的因素及预防。     

女性生殖道复发性尖锐湿疣的治疗(附47例报告)

目的 提高对女性生殖道复发性尖锐湿疣的治愈率，减少复发。方法 对47例经50％三氯醋酸或二氧化碳激光治疗失败的女性生殖道复发性尖锐湿疣患者采用γ干扰素于病变局部和(或)肌肉注射配合50％三氯醋酸和(或)激光治疗。结果 30例病变累及外阴及阴道者3周治愈；16例病变累及宫颈者4-6周治愈；1例4个月治愈。47例随访2年以上，均无复发。结论 γ干扰素局部注射治疗尖锐湿疣安全、有效，不良反应小，价格低廉，可防止复发。     

Surgical management of anal condylomata in the HIV-positive patient

A retrospective review of 677 patients who tested positive for the human immunodeficiency virus, evaluated from January 1986 to February 1988, demonstrated 119 patients (18 percent) with anal condylomata. Demographics of these patients were similar to the total human immunodeficiency virus group; ages ranged from 19 to 86 years (mean, 25 years). Ninety-four percent of patients were men, 62 percent were white, 30 percent were black, and 10 percent were other races, primarily Hispanic. Ten percent of the patients admitted to homosexual activity and 2 percent admitted to intravenous drug abuse. Sixty percent of the population had another sexually transmitted illness. The majority of patients were in early Walter Reed Classes (Stage I or II). With follow-up of 4 to 26 months (mean=12 months), the recurrence rate for anal condylomata was 26 percent after local treatment with podophyllin and 4 percent after fulguration and excision. There were no operative complications. Our study confirmed that anal condylomata and sexually transmitted diseases are common in patients who test positive for the human immunodeficiency virus and that patients who test positive for the human immunodeficiency virus with early Walter Reed stages can be expected to do well with appropriate therapy.Read at the meeting of The American Society of Colon and Rectal Surgeons, Toronto, Canada, June 11 to 16, 1989.The opinions expressed are those of the authors and do not reflect the opinions of the United States Air Force, or the Department of Defense.     

Condyloma acuminatum: Epidemiological,clinical and therapeutic aspects

Condyloma acuminatum, CA or genital warts, are benign fibro-epithelial tumors with a predilection for moist environments, especially mucosal surfaces. This sexually transmitted disease (STD) is increasing rapidly in incidence. The lesions are associated with a number of human papillomavirus (HPV) types. Some HPV types are closely linked with genital (especially cervical) dysplasia and neoplasia. Treatment consists of such traditional modalities as podophyllin, cryotherapy or surgical excision and, more recently, administration of interferon (IFN).     

CD1a和E-cadherin分子在尖锐湿疣皮损中的表达

目的：研究CD1a和E-cadherin分子在尖锐湿疣（CA）皮损中的表达情况及相互关系，探讨CA皮损局部免疫微环境的变化。方法：采用免疫组化法检测38例CA患者皮损和12名正常人包皮中CD1a和E-cadherin分子的表达。结果：CA皮损中CD1a和E—cadherin分子表达水平较正常包皮显著降低，CD1a和E-cadherin分子的表达呈正相关。结论：CA患者皮损CD1a和E—cadherin分子表达降低可能导致人乳头瘤病毒（HPV）抗原递呈障碍，在HPV逃逸机体免疫监视的过程中可能发挥重要作用。     

直肠尖锐湿疣7例临床分析

目的：探讨直肠尖锐湿疣发病的成因及治疗方法。方法：对7例直肠尖锐湿疣患的临床资料进行回顾性研究。结果：7例直肠尖锐湿疣患中，5例有肛交史，2例有生殖器、肛周尖锐湿疣病史，1例既有肛交史，又有生殖器、肛周肛周尖锐湿疣向直肠漫延。直肠尖锐湿疣采用微波去疣治疗效果最佳。     

PCR检测尖锐湿疣组织人乳头瘤病毒DNA研究

用聚合酶键反应检测12例尖锐湿疣(CA)组织的人乳头瘤病毒(HPV)DNA。结果12例CA的HPV DNA 全部阳性,其中HPV6和11型各6例,而未发现有HPV16,18和33型。10例作了组织病理观察,确诊CA 者有7例,可疑者3例。研究表明在中国CA 主要由HPV6和11型引起,且两型分布相等。在病理上未见凹空细胞时,也不能排除该病。聚合酶键反应检测HPV DNA 有助于CA 的诊断。     

薄芝糖肽联合电离子治疗尖锐湿疣疗效观察

目的:探讨薄芝糖肽联合电离子治疗尖锐湿疣(CA)的疗效及安全性。方法:随机将67例CA患者分为两组,A组37例,单纯应用电离子法治疗;B组30例,薄芝糖肽联合电离子治疗。结果:A组和B组复发率分别为62.16%、33.33%(χ2=5.51,P<0.05)。结论:薄芝糖肽联合电离子法治疗CA疗效明显高于单纯应用电离子治疗。     

治疗尖锐湿疣3种方法疗效的对比分析

目的 探讨多功能电离子术后，比较伐昔洛韦、IL－2和伐昔洛韦联合IL－23种疗法对尖锐湿疣（CA）患的疗效。方法 将CX－Ⅲ型多功能电离子术后的120例CA患随机分为3组。伐洛昔韦组（A组）40例，口服伐洛昔韦片300mg，每日2次，连服10d；IL－2组（B组）40例，肌注IL-2 10^6U，连用10d；伐洛昔韦和IL－2联合组（C组）40例，A和B组疗法连用。治疗后6个月未新发皮疹为痊愈，反之则为复发。结果 治疗后6个月未出现皮疹为痊愈。A组、B组和C组的治愈率分别为75％（10／40）；70％（12／40）和95％（2／40）。结论 伐昔洛韦与IL－2联用治疗CA患疗效高，值得推广应用。     

女阴假性温疣36例临床病理分析

本文报告３６例女阴假性温疣（Ｐｓｅｕｄｏ—ｃｏｎｄｙｌｏｍａ）。为避免与尖锐湿疣（Ｃｏｎｄｙｌｏｍａ）相混淆而造成人们不必要的心理恐慌，强调病理诊断在确诊中的重要性及病理诊断之要点。外阴不洁和直接或间接感染是引起本病的原因。注意公共浴室的消毒和养成个人良好的卫生习惯、保持外阴清洁是予防本病之重要措施。