生化汤治疗宫缩乏力性产后出血的临床疗效及对RhoA、ROCK蛋白的影响

目的:探讨生化汤治疗宫缩乏力性产后出血(PHH)的临床疗效及对患者应激指标及Rho A蛋白、Rho激酶Ⅰ(ROCKⅠ)和Rho激酶Ⅱ(ROCKⅡ)蛋白水平的影响。方法:选取2015年1月至2016年5月我院收治的PHH患者100例,随机分为实验组和对照组,各50例。对照组在胎儿娩出后注射卡贝缩宫素,实验组在对照组的基础上服用生化汤,观察比较2组止血时间、产后出血量,产后血红蛋白(Hb)水平、血压及应激指标变化、Rho A蛋白、ROCKⅠ和ROCKⅡ蛋白水平及不良反应情况。结果:治疗后实验组止血时间、产时、产后2 h、产后24 h出血量、Hb下降值、E、NE、R、AngⅡ水平均低于对照组(P0.01);2组间及治疗前后SBP、DBP比较,差异无统计学意义(P0.05);治疗后2组Rho A、ROCKⅠ和ROCKⅡ蛋白水平均显著高于治疗前(P0.05或P0.01),但2组比较,差异无统计学意义(P0.05)。结论:生化汤联合卡贝缩宫素治疗PHH无明显不良反应且疗效显著,能缩短患者的止血时间,减少出血量,降低机体应激反应,增强患者子宫平滑肌的收缩作用。     

肝炎后肝硬化患者肝脏门静脉血流量的变化及丹参对其影响

应用彩色超声多普勒测定肝炎后肝硬化患者门静脉右支主干血流速度与血流量,以正常人作对照,发现患者血管管径增粗,血流速度减慢,血流量减少,食道静脉曲张程度与管径增粗程度呈正相关,与血流速度呈负相关。丹参能加快患者与正常人门静脉血流速度与增加其血流量,但对患者血流影响更明显。     

Effects of the frequency of alcohol intake on risk factors for coronary heart disease

A cross-sectional study was conducted in 3660 male workers to examine whether the weekly frequency of alcohol intake affected serum lipids and blood pressure, which are risk factors for coronary heart disease, independently of the weekly alcohol consumption. Information regarding life-style habits and current medication was obtained by questionnaire. The effects of the frequency were examined using Tukey's test in the groups of drinkers divided according to their alcohol consumption. In moderate (189–377 ml/week) drinkers, a higher frequency of drinking was related to a higher level of HDL-cholesterol, and a lower level of triglycerides. In light (1–188 ml/week) and heavy (378–566 ml/week) drinkers, a higher frequency of drinking was also related to a higher level of HDL-cholesterol. There were no significant relations between the frequency of drinking and total cholesterol, or blood pressure in these three groups. Similar results were obtained when values were adjusted for age, body-mass index, smoking, physical activity and weekly alcohol consumption. Multiple regression analysis in the whole drinkers also showed that the weekly frequency of drinking was associated with HDL-cholesterol, but not with triglycerides (p = 0.052), total cholesterol, or blood pressure. The results suggest that the weekly frequency of drinking may affect the levels of HDL-cholesterol independently of the weekly alcohol consumption.     

复方中药冰块对扁桃腺切除术后出血量的影响

目的 观察局部应用复方中药冰块对扁桃腺切除术后出血量的影响,并做了动物实验。方法 临床将60例扁桃体切除术患者随机分为实验组和对照组。实验组30例,采用复方中药冰块,对照组30例,采用市售雪糕。结果 实验组止血作用好于对照组。两组差异有显著性(P<0.01)。结论 提示复方中药冰块止血作用明显优于传统方法,安全方便,无毒副作用的新型制剂,可广泛应用于临床。     

Is modified Carnoy’s solution as effective as Carnoy’s solution in terms of amount of bone necrosis and depth of penetration?

Carnoy’s solution, a chemical cauterisation agent, has been indicated as one of the adjuvant treatment modalities for odontogenic keratocyst. In 2000, after the ban of chloroform many surgeons adopted the use of Modified Carnoy’s solution. The purpose of this study is to compare the depth of penetration and amount of bone necrosis of Carnoy’s versus Modified Carnoy’s solution on the mandible of Wistar rats at different time intervals. Twenty-six male Wistar rats of six to eight weeks old, weighing approximately 150–200 grams, were allocated for this study. The predictor variables were type of solution and application time. The outcome variable was depth of penetration and amount of bone necrosis. Carnoy’s solution was applied on the defect on the right side of the mandible and Modified Carnoy’s solution on the left side for five minutes on eight rats, eight minutes on eight rats, and 10 minutes on eight rats. All specimens were subjected to histomorphometric analysis done using Mia image AR software. Univariate ANOVA test, and paired sample t test was done to compare the results. The depth of penetration for Carnoy’s solution was more than Modified Carnoy’s solution in the three different exposure times. Statistically significant results were observed at five minutes and eight minutes. The amount of bone necrosis was more in Modified Carnoy’s solution. The results were not statistically significant at the three different exposure times. To conclude, when one wants to use Modified Carnoy’s solution, the minimum exposure time should be 10 minutes to achieve similar results as those of Carnoy’s solution.