郭军教授治疗特发性男性不育症的经验

男性不育症中,精液分析多种参数异常且无法找到明确病因的称为特发性男性不育症,其发病率不断提高,给国内甚至全球范围内家庭带来精神及经济负担。由于病因不明确,目前现代医学尚无有效治疗方法。传统中医药通过辨证论治在治疗特发性男性不育症时具有优势,郭军教授认为该病以肾脾两虚为本,为体内湿热形成奠定基础,患者久病无子嗣,肝气不畅则郁结,气血津液运行不通则夹血瘀湿热等有形实邪,另外怪病多痰。故对于特发性男性不育症,治法注重补泻兼施,扶正祛邪,补益脾肾为主,对于湿热、痰湿、瘀血则清热祛湿化痰,活血化瘀等,并举验案1例。     

Colon and rectal cancer risk after bariatric surgery in a multicountry Nordic cohort study

Obesity is a risk factor for colorectal cancer. Yet, some research indicates that weight-reducing bariatric surgery also increases colorectal cancer risk. Our study was undertaken because current evidence examining bariatric surgery and risk of colorectal cancer is limited and inconsistent. This population-based cohort study included adults with a documented obesity diagnosis in Denmark, Finland, Iceland, Norway or Sweden in 1980–2015. The incidence of colorectal cancer in participants with obesity who had and had not undergone bariatric surgery was compared to the incidence in the corresponding background population by calculating standardized incidence ratios (SIR) with 95% confidence intervals (CI). Additionally, operated and nonoperated participants with obesity were compared using multivariable Cox regression, providing hazard ratios (HR) with 95% CIs adjusted for confounders. Among 502,772 cohort participants with an obesity diagnosis, 49,931(9.9%) underwent bariatric surgery. The overall SIR of colon cancer was increased after bariatric surgery (SIR 1.56; 95% CI 1.28–1.88), with higher SIRs ≥10 years postsurgery. The overall HR of colon cancer in operated compared to nonoperated participants was 1.13 (95% CI 0.92–1.39) and 1.55 (95% CI 1.04–2.31) 10–14 years after bariatric surgery. Bariatric surgery did not significantly increase the risk of rectal cancer (SIR 1.14, 95% CI 0.83–1.52; HR 1.08, 95% CI 0.79–1.49), but the risk estimates increased with longer follow-up periods. Our study suggests that bariatric surgery is associated with an increased risk of colon cancer, while the support for an increased risk of rectal cancer was weaker.     

中西医结合治疗癫痫伴抑郁Meta分析

目的:系统评价中西医结合治疗癫痫伴抑郁患者的临床疗效。方法:计算机检索中国知网、万方数据库、中国医学生物文献数据库、维普资讯、PubMed及Web of Science等中英文数据库,筛选出自各数据库建库以来至2018年7月关于中西医结合治疗癫痫伴抑郁的临床随机对照试验(randomized controlled trial,RCT)研究,根据系统评价标准依次进行文献质量评价和Meta分析。结果:纳入14个研究,共1183例患者。Meta分析结果显示:中西医结合治疗癫痫伴抑郁在降低HAMD评分、提高QLOIE-31评分方面优于单纯西药治疗。癫痫发作频次改善率效应值合并量OR=3.53,95%CI(1.73,7.17),Z=3.48(P=0.0005),差异有统计学意义(P<0.05)。临床安全性效应值合并量OR=0.59,95%CI(0.35,0.98),Z=2.03(P=0.04),差异有统计学意义(P<0.05)。结论:中西医结合足疗程治疗癫痫伴抑郁临床疗效优于单纯西药治疗,且临床安全性良好,但因纳入研究数量和质量有限,上述结论尚待高质量的RCT研究验证。     

胸痹心痛病患者的中医心脏康复护理意义研究

目的探讨胸痹心痛病患者的中医心脏康复护理意义。方法选取2018年1月-2019年1月在大连中医医院内一病房就诊的80例胸痹心痛病患者,经辨证分型为气虚血瘀型胸痹,随机分为试验组和对照组,对照组40例采取常规护理,试验组40例在对照组的基础上使用中医心脏康复护理,主要包括:证候施护、饮食护理、中医特色技术、情志护理、健康指导等。通过中医证候评分对治疗的有效率进行观察。结果试验组有效率为92.5%,对照组有效率为77.5%,试验组优于对照组,差异有统计学意义(P<0.05)。结论对胸痹心痛病患者的中医心脏康复护理,可以有效提高临床有效率,改善临床症状,提高患者生活质量,值得在临床推广。     

桂枝汤加减治疗营卫不和型慢性瘾疹的临床疗效

目的:观察桂枝汤加减治疗营卫不和型慢性瘾疹的临床疗效。方法:将我院门诊2017年10月-2019年10月收治的48例营卫不和型慢性瘾疹患者,按随机数表法分成对照组(24例)与实验组(24例)。对照组实施常规西药治疗,实验组实施桂枝汤合地骨皮、白鲜皮加减治疗。对照两组治疗前后症状积分、临床疗效及并发症发生率。结果:两组治疗前症状积分相比无显著差异(P>0.05)。治疗后,两组症状积分均有所下降,实验组低于对照组;实验组临床总有效率为91.67%(22/24)高于对照组的66.67%(16/24);实验组并发症发生率0(0/24)低于对照组的16.67%(4/24),差异具有统计学意义(P<0.05)。结论:在营卫不和型慢性瘾疹治疗中,采取桂枝汤加减治疗,可明显降低症状积分,提高临床治疗效果,减少并发症,效果理想。     

Biomedical microelectromechanical systems (BioMEMS): Revolution in drug delivery and analytical techniques

Advancement in microelectromechanical system has facilitated the microfabrication of polymeric substrates and the development of the novel class of controlled drug delivery devices. These vehicles have specifically tailored three dimensional physical and chemical features which together, provide the capacity to target cell, stimulate unidirectional controlled release of therapeutics and augment permeation across the barriers. Apart from drug delivery devices microfabrication technology’s offer exciting prospects to generate biomimetic gastrointestinal tract models. BioMEMS are capable of analysing biochemical liquid sample like solution of metabolites, macromolecules, proteins, nucleic acid, cells and viruses. This review summarized multidisciplinary application of biomedical microelectromechanical systems in drug delivery and its potential in analytical procedures.