唐宋“五脏中风”证治特色探析

针对金元以后五脏中风研究逐渐淡化,至今罕有研究的现象,追溯《千金方》、《太平圣惠方》中的相关内容,剖析唐宋时期五脏中风证治特色。认为,与康宋以前相比,该时期的五脏中风在病证上,逐渐由一般证候向具体病证转化;在治疗上,《千金方》寒温并用,创内风论治之先河;《太平圣惠方》突出各脏中风特点,区分五脏用药,拓展内风治法。指出唐宋时期五脏中风证治方面取得的成就对今日中医临床仍有启迪。     

卒中治风四法与微观证治学研究

为促进卒中微观证治学的传承与创新,应用微观证治学方法,从"风中五脏"立论,按肝风证治提出降压熄风、祛痰降脂、活血化瘀和降血糖的"治风四法"和相应药物,为防治高血压伴有动脉粥样硬化心脑血管病的首选方药.     

颈椎旋转复位手法合局部按揉冈下肌治疗肱骨外上髁炎40例

肱骨外上髁炎是以肘关节肱骨下端的背侧╥痛、钝痛,不能端抬重物为主要症状的临床常见病症。笔者从１９９８年４月～１９９８年１２月,用颈椎旋转复位法和局部按揉冈下肌之法治疗本病４０例,效果颇为满意,现报道如下。１　临床资料本组４０例中,男１６例,女２４例;年龄２５～５０岁,病程２天～数年,平均为６个月。左侧１２例,右侧２８例。主诉为肘外侧疼痛,常发生在拧毛巾,倒水及持重物或伸屈肘关节等活动时,局部疼痛加剧,向肩背或手背放射;其中１５例有颈部不适感,伴有背部╥痛１５例,大部分患者经过其他方法治疗,１５例…     

半夏白术天麻汤治疗梅尼埃病临床研究

目的：观察中西结合治疗梅尼埃病的临床疗效。方法：选择门诊病例114例随机分为中西药结合治疗组和西药对照组,西药选用长春西汀,舒血宁注射液等治疗,中西药结合组在西药治疗同时选用半夏白术天麻汤加味,两组均以7 d为1疗程,治疗1-2疗程后观察疗效。结果：对照组有效率为89.00%,中西结合治疗梅尼埃病有效率为94.73%,两组比较差异有显著性意义（P〉0.05）,治疗组明显优于对照组。结论：半夏白术天麻汤加味具有健脾化痰、平肝熄风的功效,舒血宁注射液、长春西汀注射液可以扩张血管、改善微循环,联合应用对梅尼埃病疗效显著。     

Asymmetry in D-2 binding in female rat striata

An asymmetry in D-2 receptor densities (Bmax) measured by [3H]N-methyl spiperone binding was found in striata from female Sprague-Dawley rats. The D-2 Bmax on the right side was on average 40% greater than the D-2 Bmax on the left side. This asymmetry is greater in magnitude and opposite in direction to that reported for males and is independent of directional preference exhibited during nocturnal circling.     

Effect of deprivation of the paradoxical phase of sleep on rotational and stereotyped behavior induced by selective agonists of dopamine receptors

Research Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow. Institute of Pharmacology, Polish Academy of Sciences, Krakow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 110, No. 11, pp. 495–497, November, 1990.     

Effects of Hydrophobicity on the Antifungal Activity of α‐Helical Antimicrobial Peptides

We utilized a series of analogs of D‐V13K (a 26‐residue amphipathic α‐helical antimicrobial peptide, denoted D1) to compare and contrast the role of hydrophobicity on antifungal and antibacterial activity to the results obtained previously with Pseudomonas aeruginosa strains. Antifungal activity for zygomycota fungi decreased with increasing hydrophobicity (D‐V13K/A12L/A20L/A23L, denoted D4, the most hydrophobic analog was sixfold less active than D1, the least hydrophobic analog). In contrast, antifungal activity for ascomycota fungi increased with increasing hydrophobicity (D4, the most hydrophobic analog was fivefold more active than D1). Hemolytic activity is dramatically affected by increasing hydrophobicity with peptide D4 being 286‐fold more hemolytic than peptide D1. The therapeutic index for peptide D1 is 1569‐fold and 62‐fold better for zygomycota fungi and ascomycota fungi, respectively, compared with peptide D4. To reduce the hemolytic activity of peptide D4 and improve/maintain the antifungal activity of D4, we substituted another lysine residue in the center of the non‐polar face (V16K) to generate D5 (D‐V13K/V16K/A12L/A20L/A23L). This analog D5 decreased hemolytic activity by 13‐fold, enhanced antifungal activity to zygomycota fungi by 16‐fold and improved the therapeutic index by 201‐fold compared with D4 and represents a unique approach to control specificity while maintaining high hydrophobicity in the two hydrophobic segments on the non‐polar face of D5.     

The anticonvulsant remacemide and its metabolite AR‐R12495AA attenuate spinal synaptic transmission and carrageenan‐induced inflammation in the young rat

The effects of the anticonvulsants remacemide [(±)‐2‐amino‐N‐(1‐methyl‐1,2‐diphenylethyl)‐acetamide hydrochloride] and its des ‐glycinated metabolite AR‐R12495AA [(±)‐1‐methyl‐1,2‐diphenylethylamine‐ monohydrochloride] on primary afferent‐induced synaptic transmission and frequency‐dependent summation of synaptic potentials were assessed in the young rat spinal cord in vitro. Behavioural studies in the rat determined the effects of these anticonvulsant compounds in the carrageenan model of inflammation. Recordings of the extracellular dorsal root‐evoked ventral root potential (DR‐VRP) revealed a significant reduction of the duration and t1/2 decay of the long latency, slow DR‐VRP by remacemide (50 and 100 μM) and AR‐R12495AA (25, 50 and 100 mM). The short‐latency, fast monosynaptic DR‐VRP peak was reduced by only the highest concentration of AR‐R12495AA (100 μM). In intracellular dorsal root‐evoked excitatory postsynaptic potentials (DR‐EPSPs) of single ventral horn neurons, AR‐R12495AA (100 μM) attenuated the time course of the long‐latency (slow) EPSP. Frequency‐dependent (0.5–2.0 Hz) summation of dorsal root‐evoked synaptic events (recorded extracellularly as the cumulative ventral root depolarization (CVRD), and intracellularly as wind‐up) was attenuated by remacemide (100 μM) and AR‐R12495AA (50 and 100 μM). Pre‐treatment with intra‐peritoneal injection of 75 mg/kg of remacemide or AR‐R12495AA caused a significant reduction of carrageenan‐induced mechanical hyperalgesia and oedema. These electrophysiological and behavioural data provide evidence that remacemide and AR‐R12495AA may also possess analgesic and anti‐inflammatory activity. Copyright 2000 European Federation of Chapters of the International Association for the Study of Pain     

三种消毒方法对手术室空气消毒效果比较

为观察不同消毒法对手术室空气消毒效果,采用现场消毒试验方法比较了3种空气消毒方法对空气中自然菌消毒效果。结果,在无人条件下,用含1500 mg/L二氧化氯消毒液气溶胶喷雾消毒,密闭作用15 m in,对手术室内空气中自然菌消亡率达到96.9%;用紫外线照射60 m in,对空气中自然菌消亡率为93.0%;用多功能循环风消毒机连续运行60 m in,可使空气中自然菌消亡率达到96.3%。在手术室有人条件下,三种消毒方法消毒处理60 m in后,空气中细菌总数均在卫生标准规定范围内;但在人员进入手术后,气溶胶喷雾消毒和紫外线照射都处于停止状态,随时间延长,细菌数不断增加;多功能循环风消毒机可继续运行,能保持细菌总数符合要求。结论,3种消毒方法在无人条件下,对室内空气中自然菌具有很好的杀灭效果;在有人条件下,只有多功能循环风消毒机可持续消毒,保持室内空气细菌总数符合规定标准。     

肿节风静脉注射液治疗肺癌5O例临床研究

目的 肿节风静脉注射液治疗肺癌的疗效。方法 肿节风静脉注射液4ml，im，2次／d，治疗前后自身对照。结果PR13例（26％），MR12例（24％），PD5例（10％）。结论肿节风静脉注射液对肺癌有较好疗效，值得进一步开发应用。