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91.
92.
Soichi Hotta Hiromasa Kashimura Shinji Hirai Akira Nakahara Hisayuki Fukutomi Toshiaki Osuga Yasuo Uchiyama 《Lasers in surgery and medicine》1995,16(3):262-271
Background and Objective: To further understand the precise process of the tumor cell degeneration after photodynamic therapy (PDT), laser hyperthermic therapy (LH), and combined treatments using an Nd:YAG laser. It is important to examine initial morphological alteration of tumor cells after these treatments. Study Design/Materials and Methods: In this study, nude mice bearing HeLa cell tumors were treated with PDT, LH, and combined treatments of the two. Tumor tissues obtained immediately after these treatments were analyzed using electron microscopy and morphometry. Results: In the combined treatments, which produced more severe effects on tumor cells, morphological features of apoptosis such as cytoplasmic condensation, blebs, and apoptotic bodies appeared in the cells, although the typical alteration in the nuclear chromatin was not seen. Conclusion: Cytoplasmic alterations may proceed more rapidly than nuclear alterations in the cellular degeneration induced by the single or combined treatments of PDT and LH. 相似文献
93.
Anne B. Fulton Ronald M. Hansen 《Documenta ophthalmologica. Advances in ophthalmology》1988,68(3-4):293-304
Scotopic b-wave stimulus/response (S/R) functions are abnormal in several human retinal degenerative disorders. However, the mechanisms by which diseases affect the S/R parameters are not yet fully known. Three experiments were done to simulate functional pathologies known to occur in retinal degenerations: 1) attenuated sensitivity of retinal units, 2) loss of rhodopsin, 3) loss of sensitivity with little or no loss of rhodopsin. None of the experimental perturbations of normal function replicated the pattern of S/R abnormalities caused by retinal degenerations. Thus, in the retinal degenerative disorders intrinsic abnormalities of cellular processing must affect the organization of distal retinal function indexed by the b-wave. 相似文献
94.
The use of a triple lumen central venous catheter, which can be shielded from laser irradiation by metal tape, as a conduit for high frequency jet ventilation in six children, is described. The problems of anaesthesia for laryngeal laser surgery and the advantages of the technique described in this paper are discussed. 相似文献
95.
目前在青光眼的临床治疗中,激光治疗已成为介于药物和手术治疗之间的一种方法,本文仅就原发性闭角型青光眼的激光周边虹膜透切术和开角型青光眼的激光滤帘成形术做一介绍。 相似文献
96.
本文将45例经Nd:YAG激光治疗的膀胱癌患者随机分组,对33例做了卡介苗(BCG)膀胱灌注,12例做了噻替派(thiotepa)膀胱灌注,并分别随访了3~18个月,平均9.8个月,BCC组膀胱癌再发率3%(1/33),噻替派组膀胱癌再发率为25%(3/12)(P<0.01)。 相似文献
97.
Ahmed M. Abu El-Asrar Eman S. Kahtani Khalid F. Tabbara 《Documenta ophthalmologica. Advances in ophthalmology》1995,89(4):313-320
In this report we describe, herewith, a patient with primary pigmentary dystrophy of the retina (retinitis pigmentosa) associated with unilateral retinal arteriovenous communication and exudative retinal detachment. The patient had complete resolution of the retinal detachment following laser photocoagulation treatment. Such association has not been previously reported. 相似文献
98.
. R. Kakigi H. Shibasaki T. Lkeda R. Neshige C. Endo Y. Kuroda 《Acta neurologica Scandinavica》1992,85(5):347-352
Pain-related somatosensory evoked potentials (pain SEPs) following CO2 laser stimulation were examined in 30 patients with peripheral neuropathies, and the results were compared with clinical sensory findings. Pain SEP findings showed a significant correlation with the clinical impairment of pain sensation, but not with the impairment of deep sensations. In contrast, conventional electrically-stimulated SEPs (electric SEPs) showed a significant correlation with deep sensations, but not with the impairment of pain sensation. Examinations of both pain SEPs and electric SEPs, therefore, are considered to be very useful to evaluate physiological functions of sensory nerves in patients with peripheral neuropathies. 相似文献
99.
S Kimel L O Svaasand M Hammer-Wilson V Gottfried S Cheng E Svaasand M W Berns 《Lasers in surgery and medicine》1992,12(4):432-440
The chick chorioallantoic membrane (CAM) model was used to study vascular effects of photodynamic therapy (PDT) and hyperthermia (HPT) and the synergism of these modalities. The CAM is a convenient medium for monitoring the modifications of the vasculature. It is possible to view the CAM and to examine structural changes of individual blood vessels in real time. Moreover, the CAM is a closed system which lends itself to mathematical modeling of the temporal and spatial temperature profile and in which HPT can be performed quantitatively and to a selected depth, using different lasers. A porphyrin-type photosensitizer solution was applied to areas of the CAM, defined by teflon O-rings placed on the surface. Uptake dynamics of the sensitizer into the CAM was determined by analyzing its fluorescence in vivo. The CAM area was irradiated with a dual-wavelength laser system composed of a dye laser at 644 nm (to induce PDT) and a CO2 laser at 10.6 microns (to bring about HPT). Damage to the CAM vasculature, due to combined PDT+HPT, was compared to the outcome of the separate modalities, and a synergistic effect of about 40% was observed. 相似文献
100.
Data on the effects of laser radiation on primary teeth are scarce. This study investigates the effects of exposing sound
enamel, photo-initiated sound enamel, sound dentine and carious dentine of extracted primary teeth to a pulsed neodymium-yttrium
aluminium garnet laser (Nd-YAG, wavelength 1.06 μm, pulse length 15μs). Each type of tissue was exposed to three fiuences.
Qualitative and quantitative assessments of the irradiated areas revealed that the most marked changes were produced in carious
dentine, followed in ranking order by sound dentine, photo-initiated enamel and sound enamel. Evidence of thermal damage to
the hard tissues peripheral to the fibre-optic tip, and considerable inter-sample variation were found. The experimental evidence
obtained in this in vitro study does not support the clinical use of pulsed laser at 1.06 μm wavelength for cutting primary
enamel and dentine. 相似文献