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21.
A human oligodendroglial tumour cell line was established in the nude mouse from a mixed oligoastrocytoma. This cell line was identified by immunoperoxidase screening for glial fibrillary acid protein (GFAP) and Leu-7, by electron microscopy, by its growth behaviour, and by radioreceptor assays for oestrogen, progestogen and androgen. At the first heterotransplantation, the tumour grew in the female but not in the male mice. GFAP-positive cells were much less abundant than in the initial tumour, although Leu-7 positive cells were plentiful. Growth curves were biphasic, and the tumours contained both oestrogen and androgen receptors. After three successive heterotransplantations in female mice, GFAP-negative, Leu-7-positive tumours with the cytological features of an oligodendroglioma were obtained. In contrast to those of the first heterotransplantation, the growth curves showed a longer latency and a single growth phase. The tumours contained both progestogen and androgen receptors but lacked oestrogen receptor. The 5th heterotransplantation in male mice exhibited rapid growth, similar to the three previous heterotransplantations in the female mice. The growth observed solely in the female mice at the first heterotransplantation was thought to derive from the hormonal status of the host. The presence of hormone receptors in the tumours at the first heterotransplantation lent support to this idea. There was no further influence of the sex of the host on tumour growth once the oligodendroglial line was established. The establishment and the development of oligodendrocytes may result from differentiation of transitory cells intermediate between astrocytes and oligodendrocytes. The effect of host-sex on the development of oligodendrocytes points to a new facet of the differentiation of CNS glial cells. 相似文献
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This article reports a case of primary intraventricular oligodendroglioma that was successfully treated by ventriculoatrial shunting and radical removal by a transventricular approach. Oligodendrogliomas very rarely occur in the ventricles. The computed tomographic findings are pointed out. 相似文献
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Summary This paper concerns two cases of cerebral oligodendroglioma (intraventricular in one case, right temporal in the other), with spinal dissemination (cervical and upper thoracic respectively), manifested clinically 2 years and 14 months respectively after removal of the cerebral tumour. Anatomical examination confirmed the diagnosis of disseminated oligodendroglioma in the leptomeninges in both cases and also in the parenchyma in the second case. 相似文献
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Yip S Butterfield YS Morozova O Chittaranjan S Blough MD An J Birol I Chesnelong C Chiu R Chuah E Corbett R Docking R Firme M Hirst M Jackman S Karsan A Li H Louis DN Maslova A Moore R Moradian A Mungall KL Perizzolo M Qian J Roldan G Smith EE Tamura-Wells J Thiessen N Varhol R Weiss S Wu W Young S Zhao Y Mungall AJ Jones SJ Morin GB Chan JA Cairncross JG Marra MA 《The Journal of pathology》2012,226(1):7-16
Oligodendroglioma is characterized by unique clinical, pathological, and genetic features. Recurrent losses of chromosomes 1p and 19q are strongly associated with this brain cancer but knowledge of the identity and function of the genes affected by these alterations is limited. We performed exome sequencing on a discovery set of 16 oligodendrogliomas with 1p/19q co-deletion to identify new molecular features at base-pair resolution. As anticipated, there was a high rate of IDH mutations: all cases had mutations in either IDH1 (14/16) or IDH2 (2/16). In addition, we discovered somatic mutations and insertions/deletions in the CIC gene on chromosome 19q13.2 in 13/16 tumours. These discovery set mutations were validated by deep sequencing of 13 additional tumours, which revealed seven others with CIC mutations, thus bringing the overall mutation rate in oligodendrogliomas in this study to 20/29 (69%). In contrast, deep sequencing of astrocytomas and oligoastrocytomas without 1p/19q loss revealed that CIC alterations were otherwise rare (1/60; 2%). Of the 21 non-synonymous somatic mutations in 20 CIC-mutant oligodendrogliomas, nine were in exon 5 within an annotated DNA-interacting domain and three were in exon 20 within an annotated protein-interacting domain. The remaining nine were found in other exons and frequently included truncations. CIC mutations were highly associated with oligodendroglioma histology, 1p/19q co-deletion, and IDH1/2 mutation (p < 0.001). Although we observed no differences in the clinical outcomes of CIC mutant versus wild-type tumours, in a background of 1p/19q co-deletion, hemizygous CIC mutations are likely important. We hypothesize that the mutant CIC on the single retained 19q allele is linked to the pathogenesis of oligodendrogliomas with IDH mutation. Our detailed study of genetic aberrations in oligodendroglioma suggests a functional interaction between CIC mutation, IDH1/2 mutation, and 1p/19q co-deletion. 相似文献
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《Neuro-oncology》2014,16(5):662-670
Background
The aim of this study was to correlate MRI features and molecular characteristics in anaplastic oligodendrogliomas (AOs).Methods
The MRI characteristics of 50 AO patients enrolled in the French national network for high-grade oligodendroglial tumors were analyzed. The genomic profiles and IDH mutational statuses were assessed using high-resolution single-nucleotide polymorphism arrays and direct sequencing, respectively. The gene expression profiles of 25 1p/19q-codeleted AOs were studied on Affymetrix expression arrays.Results
Most of the cases were frontal lobe contrast-enhanced tumors (52%), but the radiological presentations of these cases were heterogeneous, ranging from low-grade glioma-like aspects (26%) to glioblastoma-like aspects (22%). The 1p/19q codeletion (n = 39) was associated with locations in the frontal lobe (P = .001), with heterogeneous intratumoral signal intensities (P = .003) and with no or nonmeasurable contrast enhancements (P = .01). The IDH wild-type AOs (n = 7) more frequently displayed ringlike contrast enhancements (P = .03) and were more frequently located outside of the frontal lobe (P = .01). However, no specific imaging pattern could be identified for the 1p/19q-codeleted AO or the IDH-mutated AO. Within the 1p/19q-codeleted AO, the contrast enhancement was associated with larger tumor volumes (P = .001), chromosome 9p loss and CDKN2A loss (P = .006), genomic instability (P = .03), and angiogenesis-related gene expression (P < .001), particularly for vascular endothelial growth factor A and angiopoietin 2.Conclusion
In AOs, the 1p/19q codeletion and the IDH mutation are associated with preferential (but not with specific) imaging characteristics. Within 1p/19q-codeleted AO, imaging heterogeneity is related to additional molecular alterations, especially chromosome 9p loss, which is associated with contrast enhancement and larger tumor volume. 相似文献28.
Giannini C Burger PC Berkey BA Cairncross JG Jenkins RB Mehta M Curran WJ Aldape K 《Brain pathology (Zurich, Switzerland)》2008,18(3):360-369
Intergroup Radiation Therapy Oncology Group Trial 9402 study, a phase III trial of chemotherapy plus radiotherapy (PCV-plus-RT) vs. radiotherapy alone for pure and mixed anaplastic oligodendroglioma confirmed the prognostic significance of 1p 19q deletion and showed that only progression-free survival (PFS) was prolonged in PCV-plus-RT-treated patients and only in association with 1p 19q deletion. We reviewed tumor histopathology, separating 115 tumors deemed to be classic for oligodendroglioma (CFO) from 132 lacking classic features of oligodendroglioma (NCFO) and evaluated the relationship of histopathology and 1p 19q status to treatment and outcome. The study disclosed: (i) overall survival (OS) of patients with CFO was significantly longer than for patients with NCFO (P < 0.0001) and was not affected by necrosis. Median OS for CFO patients with and without necrosis was 6.6 and 6.3 years (OS log-rank P = not significant), respectively, in contrast to NCFO showing 1.9 and 3.3 years respectively (OS log-rank P = 0.014). (ii) Classic oligodendroglial morphology was highly associated with 1p 19q deletion, present in 80% of CFO and only in 13% of NCFO. (iii) On multivariate analysis, both classic oligodendroglial morphology and 1p 19q deletion remained significantly associated with PFS and OS. (iv) Patients with CFO treated with PCV-plus-RT showed a trend toward increased survival compared with CFO treated with RT (P = 0.08). Median OS was not reached in the PCV-plus-RT group and was 6.3 years in RT group. These findings suggest that classic oligodendroglial morphology combined with 1p 19q deletion may in the future be predictive of chemotherapeutic response and survival. 相似文献
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Hendrikus J. Dubbink Peggy N. Atmodimedjo Johan M. Kros Pim J. French Marc Sanson Ahmed Idbaih Pieter Wesseling Roelien Enting Wim Spliet Cees Tijssen Winand N. M. Dinjens Thierry Gorlia Martin J. van den Bent 《Neuro-oncology》2016,18(3):388-400