高危人群微量乙肝疫苗免疫效果动态观察

采用微量乙肝疫苗（总剂量为６μｇ）对ＨＢＶ高流行区居民进行随机对照研究，免疫Ⅰ组（疫苗＜８℃保存）Ｔ１２抗体阳转率和保护率分别为９０．８％和８７．０％，和对照组相比，差异显著（Ｐ均＜０．００１）；和常规剂量（总剂量９０μｇ）比，其抗体阳转率和保护率基本相同。提示ＨＢＶ高流行区可用微量乙肝苗代替常量乙肝苗进行预防接种。免疫Ⅰ组和免疫Ⅱ组（乙肝疫苗室温保藏２８℃±）免疫效果和保护率基本相同，认为室温条件下乙肝疫苗６个月内效价不变。     

A Comparative Study of Dihydroartemisin in Compounds in Treatment of Uncomplicated Falciparum Malaria in Kampong of Cambodia

Objective: To compare the safety and efficacy of two compounds of dihydroartemisinin(DHA) -Artekin and Artekin (T) in the treatment of uncomplicated falciparum malaria. Methods:The regimen of 8-tablet for 2 days of Artekin and Artekin (T) were applied to 100 patients with uncomplicated falciparum malaria, who were randomly divided into two groups. Each group contained 50 cases. The cure rate, the mean parasites clearance time, the mean fever clearance and side-effects were observed to assess the safety and efficacy of the compounds used. Results: The mean parasites clearance time was 31. 7±9.0 hours in the Artekin group and 32. 8±8. 8 hours in Artekin (T) group respectively; the mean fever clearance time was 12. 7±7. 2 hours in Artekin group and 16. 5±7. 9 hours in Artekin (T) group; there were no recrudescence case in both groups within the 28 days of follow-up, the cure rates in Artekin group and Artekin (T) groups were 100%. It indicated that the tolerability of both compounds were very good, the     

应用斑秃治疗仪治疗斑秃患者的疗效观察

目的对145例斑秃患者发病情况分析及治疗效果评价。方法采用问卷调查方式对门诊就诊的145例斑秃患者进行调查,收集斑秃患者发病可能或伴发因素,并根据调查及临床检查结果对145例斑秃患者随机分组,并分别采用斑秃治疗仪(治疗组)和胱氨酸、天麻首乌片口服治疗(对照组)。结果治疗组治愈率为94.2%、有效率为98.1%,对照组治愈率为71.4%、有效率为81.0%。结论斑秃治疗仪治疗斑秃疗效优于对照组。     

The potential of mild testicular heating as a safe, effective and reversible contraceptive method for men

A preliminary assessment of the contraceptive efficacy of a daily mild increase (1–2°c) in testicular temperature during waking hours is reported in nine couples using two techniques of non-surgical fixation of the testes close to the inguinal canal. With technique 1, immobilization was achieved by passing the penis and the empty scrotum through a hole made in close-fitting underwear; there was one pregnancy, hm a man who stopped the heating after 7 weeks, for 42 cycles of exposure in three couples. With technique 2, immobilization was achieved by adding a ring of soft material surrounding the hole in the underwear; there was no pregnancy for 117 cycles of exposure in six couples. Reversibility and safety were assessed. These preliminary results suggest that a daily mild increase in testicular temperature could be a potential contraceptive method for men.     

纳米抗菌剂抑菌杀菌性能研究

目的：检测纳米抗菌剂对标准菌株的杀菌、抑菌性能和高温对其抑菌效果的影响。方法：目标菌为大肠杆菌、金黄色葡萄球菌和白色念珠菌，通过悬液定量杀灭试验和抑菌环试验检测纳米抗菌剂的杀菌、抑菌能力。结果：水溶性纳米抗菌膜溶于5ml灭菌水中作用l0min可杀灭95．39％的金黄色葡萄球菌和93．28％的白色念珠菌，复合了纳米银的抗菌医用棉条、烧烫伤贴、创伤贴对大肠杆菌和金黄色葡萄球菌的抑菌环直径大于l0mm，对白色念珠菌的抑菌环直径大于7mm。结论：纳米抗菌剂对细菌繁殖体和白色念珠菌具有良好的抑菌、杀菌作用，高压灭菌处理对纳米银抗菌剂抑菌效果影响不大，但织物构造对其抑菌效果有影响。     

美宝湿润烧伤膏治疗急性肛裂疗效观察

目的：对美宝湿润烧伤膏(MEBO)、肛裂膏外用治疗急性肛裂进行疗效分析，判断其优劣。方法：将2000-2002年我院治疗的188例急性肛裂患者随机分为A组和B组，两组均采用相同的全身治疗，其中A组采用MEBO外用，B组采用肛裂膏外用。通过跟踪随访，在平均愈合时间、治愈率两方面进行判断分析，比较优劣。结果：A组在平均愈合时间、治愈率方面均优于B组。结论：湿润烧伤膏外用治疗急性肛裂优于肛裂膏，为治疗急性肛裂较好的外用药。     

优立新治疗急性细菌性感染的临床观察

优立新与头孢噻肟随机对照治疗呼吸道和泌尿道感染４０例，临床有效率各为１００％和９５％（Ｐ＞０．０５），细菌阴转率各为９４，１％和１００％（Ｐ＞０．０５）。无显著性差异。优立新共治疗３０例，临床有效率和细菌阴转率分别为１００％和９６％。两药副反应均轻微。无因副反应而停药。在优立新治疗病例中，有２例出现皮疹。另２例为肝功能ＡＬＴ和ＡＳＴ暂时性轻度增高。     

贯众提取液对革兰氏阳性球菌的抑菌作用

目的：了解贯众(Dryopteris crossirhizomz)不同提取液对革兰氏阳性球菌的抑菌作用。方法：分别用水以及3种不同pH值的70％乙醇为溶媒提取贯众干品以制备贯众提取液，利用打孔法和试管稀释法测定提取液对13种微生物的抑制效果。结果：每1ml含生药1g的贯众醇提液、水提液对革兰氏阳性菌有较强的抑制作用，尤其是革兰氏阳性球菌如金黄色葡萄球菌和甲型溶血性链球菌等。对革兰氏阴性菌和真菌的抑制作用较弱，但对普通变形杆菌则有较强的抑制作用。不同pH值的抽提溶剂对药物的有效抑菌成份的提出效果不同，抽提溶剂pH越小，有效成份的提出效果越好。结论：贯众醇提液、水提液对革兰氏阳性菌有较强的抑制作用，尤其是对革兰氏阳性球菌，而对革兰氏阴性菌和真菌的抑制作用则较弱。贯众的抗菌成份易溶于水，抽提效果随pH减小而增加。