双氯芬酸钠缓释胶囊治疗20例老年人癌痛

目的：研究双氯芬酸钠缓释胶囊用于老年癌痛患者的镇痛效果及不良反应。方法：选择20例轻度或中度癌痛的老年患者,口服双氯芬酸钠缓释胶囊100mg,每晚次。观察患者的镇痛效果及不良反应。结果：双氯芬酸钠缓释胶囊用于老年癌痛患者后,镇痛效果明显且无明显不良反应。结论：对于轻度或中度癌痛的老年患者,口服双氯芬酸钠缓释胶囊100mg,每晚1次,是安全、有效和简单的控制癌痛的方法。     

健康志愿者中两种国产双氯芬酸钠缓释剂的相对生物利用度

目的：研究两种国产双氯芬酸钠缓释剂在12名男性健康志愿者中的药物动力学和相对生物利用度。方法：根据交叉试验方案po单剂量100 mg及多剂量两种双氯芬酸钠缓释制剂,采用反相高效液相色谱法测定血清中双氯芬酸钠的浓度。结果：po单剂量100 mg研制片AUC、cmax、tmax、T1/2α、T1/2β分别为(5 753±2 161) (h*ng)/ml、(675.4±141.6) ng/ml、(2.284±0.542) h、(0.943 0±0.582 4) h、(6.713±2.208) h;对照片为(5 150±2 167) (h*ng)/ml、(620.1±187.1) ng/ml、(2.491±0.645) h、(1.060 0±0.682 9) h、(6.159±2.372) h,研制片的相对生物利用度为107.9%。po多剂量研制片AUC、cmax、tmax、T1/2α和T1/2β分别为(5 915±1 112) (h*ng)/ml、(766.5±173.0) ng/ml、(2.670±0.770) h、(1.690±1.060) h、(5.460±2.070) h;对照片为(5 781±1 849) (h*ng)/ml、(759.2±216.3) ng/ml、(2.310±0.520) h、(1.200±0.830) h、(6.160±2.210) h,研制片的相对生物利用度为102.3%。两种国产缓释制剂的所有药物动力学参数经统计学(SPSS 软件)处理均无显著性差异(P＞0.05),用双向单侧t检验对其主要药物动力学参数进行检验。结论：两种国产双氯芬酸钠缓释制剂具有生物等效性。     

中医疗法治疗腰椎间盘突出症临床观察

目的：观察中医疗法综合治疗腰椎间盘突出症的疗效。方法：将腰椎间盘突出症患者分为治疗组32例和对照组30例,治疗组选用中药、牵引、推拿、针灸综合治疗,对照组予以口服双氯芬酸纳缓释胶囊治疗。观察两组疗效进行对比。结果：治疗组的疗效显著优于对照组（P〈0．05）。结论：中医疗法综合治疗与1：2服双氯芬酸纳缓释胶囊治疗腰椎间盘突出症均有疗效,但中医疗法具有更好的长期疗效和整体疗效。     

因子设计-重叠等高线图法优化双氯芬酸钾口腔黏附片处方

目的优化双氯芬酸钾口腔黏附片处方。方法采用32满因子设计试验考察因素A(卡波姆和羟丙甲基纤维素的总量在处方中所占的比例)和因素B(卡波姆与羟丙甲基纤维素的质量比)对黏附时间和体外30、180、480 m in的累积释放度的影响,试验数据分别采用线性方程和二次多项式拟合,根据最佳数学模型绘制效应面和等高线图,通过重叠等高线图确定最优处方。结果2个影响因素和4个评价指标之间存在定量关系,最优处方:卡波姆和羟丙甲基纤维素的总量在处方中占30%,卡波姆与羟丙甲基纤维素的质量比为0.75∶1。优化处方各指标的预测值和目标值较接近。结论采用因子设计-重叠等高线图法完成了双氯芬酸钾口腔黏附片的多目标同步优化。     

Preparation and Enhancing Properties of pH-Sensitive Hydrogel in Light of Gum Ghatti-cl-poly(acrylic acid)/ – o-MWCNT for Sodium Diclofenac Drug Release

Gum ghatti (GG) is used as a biopolymer, acrylic acid (AA) is used as a synthetic monomer, ammonium persulphate (APS) is used as an initiator, and methylene bis-acrylamide (MBA) is used as a cross-linker in the current study to create gum ghatti-cl-poly(acrylic acid)-o-MWCNT hydrogels. The –o-MWCNT (0, 10, 20, 30, 40, and 50 mg) is added to the hydrogel as a filler. Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and X-ray diffraction (XRD) analyses are used to characterize the crosslinked hydrogels. The successful polymerization of the graft is confirmed by these spectroscopic studies. Sodium diclofenac (SD) as a model drug is utilized. Swelling tests are also conducted at pH 6.8 on all prepared hydrogels. In a similar manner, all hydrogel preparations are subjected to an in vitro study at neutral (pH 7.4), acidic (pH 1.2), and basic (pH 9.2) mediums, and a higher drug release is observed at pH 7.4. The Higuchi model, the Korsmeyer–Peppas model, and various zero-order and first-order kinetics are utilized in the investigation of the drug release order mechanism from the hydrogels. The drug release data favor the Korsmeyer–Peppas model, which describes the “n” diffusion exponent that controls the drug release mechanism from synthesized hydrogels. The “n” values control the Fickian diffusion (Case-I diffusional) like coupled diffusion (0.45 ≤ n). According to the results presented here, GGAACNT-based hydrogels can be used in biomedical fields, especially for controlled drug release.