全文获取类型
收费全文 | 93495篇 |
免费 | 10463篇 |
国内免费 | 3280篇 |
专业分类
耳鼻咽喉 | 696篇 |
儿科学 | 1910篇 |
妇产科学 | 1454篇 |
基础医学 | 9724篇 |
口腔科学 | 1187篇 |
临床医学 | 8475篇 |
内科学 | 6296篇 |
皮肤病学 | 891篇 |
神经病学 | 2200篇 |
特种医学 | 4678篇 |
外国民族医学 | 123篇 |
外科学 | 12091篇 |
综合类 | 14691篇 |
现状与发展 | 25篇 |
一般理论 | 1篇 |
预防医学 | 3060篇 |
眼科学 | 626篇 |
药学 | 6086篇 |
65篇 | |
中国医学 | 2469篇 |
肿瘤学 | 30490篇 |
出版年
2024年 | 193篇 |
2023年 | 1363篇 |
2022年 | 2276篇 |
2021年 | 4352篇 |
2020年 | 3698篇 |
2019年 | 3335篇 |
2018年 | 3117篇 |
2017年 | 3401篇 |
2016年 | 3788篇 |
2015年 | 4294篇 |
2014年 | 5949篇 |
2013年 | 6222篇 |
2012年 | 5284篇 |
2011年 | 5763篇 |
2010年 | 4568篇 |
2009年 | 4525篇 |
2008年 | 4557篇 |
2007年 | 4912篇 |
2006年 | 4627篇 |
2005年 | 4109篇 |
2004年 | 3519篇 |
2003年 | 3115篇 |
2002年 | 2790篇 |
2001年 | 2480篇 |
2000年 | 2005篇 |
1999年 | 1813篇 |
1998年 | 1511篇 |
1997年 | 1420篇 |
1996年 | 1207篇 |
1995年 | 1066篇 |
1994年 | 862篇 |
1993年 | 698篇 |
1992年 | 579篇 |
1991年 | 508篇 |
1990年 | 389篇 |
1989年 | 364篇 |
1988年 | 355篇 |
1987年 | 304篇 |
1986年 | 250篇 |
1985年 | 315篇 |
1984年 | 270篇 |
1983年 | 170篇 |
1982年 | 219篇 |
1981年 | 203篇 |
1980年 | 122篇 |
1979年 | 121篇 |
1978年 | 87篇 |
1977年 | 61篇 |
1976年 | 54篇 |
1975年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 78 毫秒
11.
12.
Her-Shyong Shiah Nai-Jung Chiang Chia-Chi Lin Chia-Jui Yen Hui-Jen Tsai Shang-Yin Wu Wu-Chou Su Kwang-Yu Chang Ching-Chiung Wang Jang-Yang Chang Li-Tzong Chen 《The oncologist》2021,26(4):e567-e579
Lessons Learned
- SCB01A is a novel microtubule inhibitor with vascular disrupting activity.
- This first‐in‐human study demonstrated SCB01A safety, pharmacokinetics, and preliminary antitumor activity.
- SCB01A is safe and well tolerated in patients with advanced solid malignancies with manageable neurotoxicity.
13.
Tumor tissue is composed of tumor cells and tumor stroma. Tumor stroma contains various immune cells and non-immune stromal cells, forming a complex tumor microenvironment which plays pivotal roles in regulating tumor growth. Recent successes in immunotherapies against tumors, including immune checkpoint inhibitors, have further raised interests in the immune microenvironment of liver carcinoma. The immune microenvironment of tumors is formed because of interactions among tumor cells, immune cells and non-immune stromal cells, including fibroblasts and endothelial cells. Different patterns of immune microenvironment are observed among different tumor subtypes, and their clinicopathological significance and intertumor/intratumor heterogeneity are being intensively studied. Here, we review the immune microenvironment of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and liver metastasis of colorectal adenocarcinoma, focusing on its histopathological appearance, clinicopathological significance, and relationship with histological and molecular classifications. Understanding the comprehensive histopathological picture of a tumor immune microenvironment, in addition to molecular and genetic approaches, will further potentiate the effort for precision medicine in the era of tumor-targeting immunotherapy. 相似文献
14.
15.
16.
Marike Gabrielson Mattias Hammarström Magnus Bäcklund Jenny Bergqvist Kristina Lång Ann H Rosendahl Signe Borgquist Roxanna Hellgren Kamila Czene Per Hall 《International journal of cancer. Journal international du cancer》2023,152(11):2362-2372
Tamoxifen prevents recurrence of breast cancer and is suggested for preventive risk-reducing therapy. Tamoxifen reduces mammographic density, a proxy for therapy response, but little is known about its effects in remodelling normal breast tissue. Our study, a substudy within the double-blinded dose-determination trial KARISMA, investigated tamoxifen-specific changes in breast tissue composition and histological markers in healthy women. We included 83 healthy women randomised to 6 months daily intake of 20, 10, 5, 2.5, 1 mg of tamoxifen or placebo. The groups were combined to “no dose” (0-1 mg), “low-dose” (2.5-5 mg) or “high-dose” (10-20 mg) of tamoxifen. Ultrasound-guided biopsies were collected before and after tamoxifen exposure. In each biopsy, epithelial, stromal and adipose tissues was quantified, and expression of epithelial and stromal Ki67, oestrogen receptor (ER) and progesterone receptor (PR) analysed. Mammographic density using STRATUS was measured at baseline and end-of-tamoxifen-exposure. We found that different doses of tamoxifen reduced mammographic density and glandular-epithelial area in premenopausal women and associated with reduced epithelium and increased adipose tissue. High-dose tamoxifen also decreased epithelial ER and PR expressions in premenopausal women. Premenopausal women with the greatest reduction in proliferation also had the greatest epithelial reduction. In postmenopausal women, high-dose tamoxifen decreased the epithelial area with no measurable density decrease. Tamoxifen at both low and high doses influences breast tissue composition and expression of histological markers in the normal breast. Our findings connect epithelial proliferation with tissue remodelling in premenopausal women and provide novel insights to understanding biological mechanisms of primary prevention with tamoxifen. 相似文献
17.
18.
三阴性乳腺癌(triple negative breast cancer,TNBC)是雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)及人类表皮生长因子受体(human epidermal growth factor-2,HER-2)均不表达的乳腺癌。按其功能特征可归纳为5类分子分型:以DNA修复缺陷或生长因子为途径的基底细胞样三阴性乳腺癌;以上皮-间充质转化和肿瘤干细胞为特征的间质样三阴性乳腺癌;免疫调节型三阴性乳腺癌;雄激素受体过表达的管腔/分泌型三阴性乳腺癌;HER-2富集型三阴性乳腺癌。三阴性乳腺癌恶性程度高且异型性较大,其治疗困难且预后较差,内分泌治疗及靶向治疗不敏感。目前很多学者对于三阴性乳腺癌的治疗各有研究,并有临床试验证实下述治疗有效。 相似文献
19.
María del Carmen Azorín Samper Marta Hernandorena Gonzlez Alberto Ibez Arias Sandra Díaz Sierra Marta Bertolo Domínguez Flix Checa Ayet 《The breast journal》2020,26(2):252-254
Breast pseudoaneurysms after a core needle biopsy are a rare complication with a low incidence. However, it is important to be aware of the possibility of complications that require treatment. 相似文献