全文获取类型
收费全文 | 2841篇 |
免费 | 217篇 |
国内免费 | 105篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 7篇 |
妇产科学 | 1篇 |
基础医学 | 148篇 |
口腔科学 | 222篇 |
临床医学 | 213篇 |
内科学 | 159篇 |
皮肤病学 | 20篇 |
神经病学 | 6篇 |
特种医学 | 28篇 |
外科学 | 62篇 |
综合类 | 370篇 |
预防医学 | 115篇 |
眼科学 | 14篇 |
药学 | 1325篇 |
1篇 | |
中国医学 | 450篇 |
肿瘤学 | 10篇 |
出版年
2024年 | 8篇 |
2023年 | 41篇 |
2022年 | 71篇 |
2021年 | 169篇 |
2020年 | 104篇 |
2019年 | 125篇 |
2018年 | 84篇 |
2017年 | 128篇 |
2016年 | 130篇 |
2015年 | 138篇 |
2014年 | 208篇 |
2013年 | 325篇 |
2012年 | 246篇 |
2011年 | 182篇 |
2010年 | 113篇 |
2009年 | 113篇 |
2008年 | 111篇 |
2007年 | 126篇 |
2006年 | 104篇 |
2005年 | 102篇 |
2004年 | 96篇 |
2003年 | 69篇 |
2002年 | 49篇 |
2001年 | 53篇 |
2000年 | 31篇 |
1999年 | 35篇 |
1998年 | 23篇 |
1997年 | 31篇 |
1996年 | 32篇 |
1995年 | 22篇 |
1994年 | 10篇 |
1993年 | 16篇 |
1992年 | 15篇 |
1991年 | 7篇 |
1990年 | 10篇 |
1989年 | 13篇 |
1988年 | 5篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1978年 | 3篇 |
排序方式: 共有3163条查询结果,搜索用时 203 毫秒
11.
四种口服头孢菌素的体外抗菌活性的比较研究 总被引:2,自引:0,他引:2
本文报道口服Cefixime对900株需氧菌和厌氧菌的体外抗菌作用,并与其它口服的头孢克罗、头孢羟氨苄和头孢氨苄进行了比较。Cefixime对链球菌具较强作用,但对葡萄球菌的作用较差;对肠球菌无效。对肠杆菌科细菌的抗菌活性四者之中以Cefixime最强。Cefixime对头孢氨苄耐药株仍具高度活性,其MIC均值可降低60~1200倍以上。绿脓杆菌、硝酸盐阴性杆菌、鲁氏不动杆菌和产碱杆菌对Cefixime和其它3种头孢菌素的敏感性均较差。四者对厌氧菌的作用除厌氧球菌外其抗菌活性都很弱。Cefixime对β-内酰胺酶稳定,口服吸收良好,抗菌作用强,是一个值得进行临床研究的口服头孢菌素。 相似文献
12.
对天津市新近临床分离的414株细菌进行了甲氟哌酸(Pflx)和氟哌酸(Nflx)体外抗菌活性研究。结果显示Pflx对绝大多数肠杆菌和细菌、不动杆菌有良好抗菌活性,抑菌率>90%。对绿脓杆菌、MSSA及凝固酶阴性葡萄球菌有中度抗菌作用,抑菌率分别为85%、87.5%、87.5%。对MRSA和链球菌抗菌活性稍差,抑菌率在40%~68.42%之间。Nflx体外抗菌活性和Pflx相似。此外,18例药敏试验耐Pflx和Nflx细菌感染患者,经Pflx治疗,肺化脓症1例显效,余17例难治性尿路感染者1例痊愈、9例显效、5例进步、2例无效。 相似文献
13.
A Gauger† S Fischer† M Mempel† T Schaefer‡ R Foelster-Holst§ D Abeck† J Ring†¶ 《Journal of the European Academy of Dermatology and Venereology》2006,20(5):534-541
BACKGROUND: Microbial skin colonization with Staphylococcus aureus is known to play an important role in atopic eczema (AE). Recently, an antibacterial effect of silver-coated textiles on S. aureus colonization has been demonstrated. OBJECTIVES: To investigate clinical efficacy and functionality of silver-coated textiles in AE, a multicentre, double-blind, placebo-controlled trial was conducted. PATIENTS/METHODS: From November 2001 to August 2002, 68 consecutive outpatients clinically diagnosed with generalized AE were included in the study. Inclusion criteria were the clinical diagnosis of AE with a moderate severity as measured by the scoring of atopic dermatitis (SCORAD) index with at least 20. Patients were instructed to wear either silver-coated (verum, 35 patients + 2 dropouts) or cotton garments (placebo, 22 patients + 9 dropouts) directly on the skin for 2 weeks. Only basic skin care and ongoing therapy with topical steroids or oral antihistamines was permitted. Clinical severity was assessed using the 'SCORAD' before, during and at the end of study. Quality of life (QOL), wearing comfort (WC) and functionality (FU) of study clothes were measured in parallel. Patients documented their subjective and objective symptoms daily. RESULTS: In the verum group, eczema improved significantly after 1 week with further enhancement until the end of study (P = 0.03 and P < 0.001). Silver-coated textiles were comparable to cotton in WC and FU. Pruritus and self-assigned skin condition improved significantly more than with placebo (P < 0.001 and P = 0.003). CONCLUSIONS: In conclusion, silver-coated textiles are able to improve objective and subjective symptoms of AE significantly within 2 weeks, showing a good wearing comfort and functionality comparable to cotton. 相似文献
14.
A. J. Ferdous S. N. Islam M. Ahsan C. M. Hasan Z. U. Ahmed 《Phytotherapy research : PTR》1992,6(3):137-140
The antibacterial activity of the volatile oil of Nigella sativa seeds was studied against 37 isolates of Shigella dysenteriae 1, Shigella flexneri, Shigella sonnei and Shigella boydii and 10 strains of Vibrio cholerae and Escherichia coli. Most of the strains were clinically resistant to ampicillin, co-trimoxazole and tetracycline. All the strains tested showed promising sensitivity to the volatile oil. The minimum inhibitory concentration (MIC) of the volatile oil for Shigella, Vibrio and Escherichia strains tested was between 50–400 μg/mL. 相似文献
15.
16.
磺胺噻二嗪硫酮衍生物的合成及其抑菌活性 总被引:1,自引:0,他引:1
利用药物化学骈合原理设计并合成了一系列新的3,5-二取代1,3,5-噻二嗪-2-硫酮类化合物,其结构经红外光谱,紫外光谱及元素分析证实,抑菌活性试验显示了良好的抑菌活性。 相似文献
17.
M Fujita H Egawa T Miyamoto J Nakano J Matsumoto 《European journal of medicinal chemistry》1996,31(12):981-988
Diethyl 1-cyclopropyl-5,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3,6-dicarboxylate 4 as a key-intermediate was synthesized via the Dieckmann reaction. The reaction of 4 with nucleophiles proceeded regioselectively at C-5. Facile cyclization between the C-5 and C-6 side chains of the resulting products gave novel pyrroloquinolones 10 and 12 and pyrazoloquinolones 15. They were converted into a series of cyclic amino-substituted pyrroloquinolones 17–21 and pyrazoloquinolones 22–24, and their in vitro antibacterial activities were tested. 1H-Pyrrolo[2,3-f]quinolone 17a and 2H-pyrrolo[3,4-f]quinolone 21a exhibited a potent in vitro antibacterial activity. 相似文献
18.
Hexane and methanol extracts of heartwood, bark/sapwood and leaves of twelve taxa of Juniperus from the United States were assayed for antifungal and antibacterial activities. The hexane extract of the heartwood of several junipers appeared comparable in antibacterial activity to streptomycin. Antibacterial activity of the hexane extracts from the bark/sapwood of J. monosperma and J. californica were comparable to streptomycin. No appreciable antibacterial activities were found in the leaf extracts from any species examined. No antifungal activities comparable to amphotericin B were found in either hexane or methanol extracts of the heartwood nor from the bark/sapwood. Antifungal activity against Cryptococcus neoformans comparable to amphotericin B was found in the hexane extract of the leaves of J. occidentalis var. australis. The methanol extracts from the leaves of J. osteosperma and J. californica had antifungal activities comparable to amphotericin B against Trichophyton mentagrophytes. 相似文献
19.
贯众提取液对革兰氏阳性球菌的抑菌作用 总被引:6,自引:0,他引:6
目的:了解贯众(Dryopteris crossirhizomz)不同提取液对革兰氏阳性球菌的抑菌作用。方法:分别用水以及3种不同pH值的70%乙醇为溶媒提取贯众干品以制备贯众提取液,利用打孔法和试管稀释法测定提取液对13种微生物的抑制效果。结果:每1ml含生药1g的贯众醇提液、水提液对革兰氏阳性菌有较强的抑制作用,尤其是革兰氏阳性球菌如金黄色葡萄球菌和甲型溶血性链球菌等。对革兰氏阴性菌和真菌的抑制作用较弱,但对普通变形杆菌则有较强的抑制作用。不同pH值的抽提溶剂对药物的有效抑菌成份的提出效果不同,抽提溶剂pH越小,有效成份的提出效果越好。结论:贯众醇提液、水提液对革兰氏阳性菌有较强的抑制作用,尤其是对革兰氏阳性球菌,而对革兰氏阴性菌和真菌的抑制作用则较弱。贯众的抗菌成份易溶于水,抽提效果随pH减小而增加。 相似文献
20.
目的 探讨银离子(Ag+)、铜离子(Cu2+)、锌离子(Zn2+)对5种常见念珠菌(白色念珠菌、热带念珠菌、近平滑念珠菌、克柔念珠菌和光滑念珠菌)的抗菌作用。方法 使用去离子水分别将硝酸银、氯化铜和氯化锌配制为0.1 mol·L-1的水溶液。取保存的白色念珠菌标准菌株ATCC-60193、近平滑念珠菌、光滑念珠菌、热带念珠菌、克柔念珠菌,加入溶菌肉汤培养液,使用比浊仪调配菌液浊度为0.5麦氏单位,然后使用无菌去离子水将菌液稀释至106 CFU·L-1。取配制好的0.1 mol·L-1的硝酸银、氯化铜和氯化锌溶液,分别倍比稀释为6个浓度(10-2、10-3、10-4、10-5、10-6、10-7 mol·L-1),分别取各浓度的金属离子溶液100μL与预制好的5种念珠菌悬液100μL进... 相似文献