肥胖与骨质疏松关系的研究进展

肥胖和骨质疏松症是常见疾病。两者关系尚存争议，未能统一。研究表明骨量与脂肪代谢间存在联系，脂肪分泌的多种生物活性分子，如雌激素、抵抗素、瘦素、脂联素、IL-6等都参与骨代谢过程。同时，影响干细胞分化的几个调控途径也会影响骨质疏松的发生。本文就脂肪组织对骨质疏松症发生的作用及机制进行综述。     

Childhood obesity: Implications on adipose tissue dynamics and metabolic health

Obesity is the leading risk factor for the development of type 2 diabetes and cardiovascular diseases. Childhood obesity represents an alarming health challenge because children with obesity are prone to remain with obesity throughout their life and have an increased morbidity and mortality risk. The ability of adipose tissue to store lipids and expand in size during excessive calorie intake is its most remarkable characteristic. Cellular and lipid turnovers determine adipose tissue size and are closely related with metabolic status. The mechanisms through which adipose tissue expands and how this affects systemic metabolic homeostasis are still poorly characterized. Furthermore, the mechanism through which increased adiposity extends from childhood to adulthood and its implications in metabolic health are in most part, still unknown. More studies on adipose tissue development in healthy and children with obesity are urgently needed. In the present review, we summarize the dynamics of white adipose tissue, from developmental origins to the mechanisms that allows it to grow and expand throughout lifetime and during obesity in children and in different mouse models used to address this largely unknown field. Specially, highlighting the role that excessive adiposity during the early life has on future's adipose tissue dynamics and individual's health.