从《孙子兵法》窥探中医治未病思想

《黄帝内经》首次提出治未病理论,但其思想基础早在《孙子兵法》就已初见端倪。兵家与医家似不相干,但殊途同源,其两者同根植于中国传统文化,具有共同的哲学思想和思维方式。文章从未病先防、欲病救萌、已病防变、瘥后防复4个方面窥探《孙子兵法》中的治未病思想,引经论证,以探其微而穷其理。     

孙素平从浊毒辨治痛风经验总结

痛风是由于体内嘌呤代谢障碍、尿酸生成过多或/和尿酸排泄减少,致血中尿酸浓度增高所引起的一组异质性疾病。临床上以高尿酸血症、特征性急性关节炎反复发作、痛风结形成为特点,严重者可致关节畸形及功能障碍、急性梗阻性肾病或痛风性肾病。西药有促进尿酸排泄、抑制尿酸生成及抗炎镇痛等不同作用,但多数药物的副作用较大,不宜长期服用,较难控制复发。中医药治疗痛风有着一定的优势,尤其在慢性缓解期稳定降尿酸和防止关节为复发方面具有较好作用。     

孙桂芝辨治胃癌经验

介绍孙桂芝教授辨治胃癌的经验。强调以人为本,以脾肾为中心,兼调身心,协调内外;扶正祛邪,坚持守方,以"持久战"对抗胃癌及其复发转移。     

Sun protection and antibacterial activities of carotenoids from the soft coral Sinularia sp. symbiotic bacteria from Panjang Island,North Java Sea

Carotenoids have shown beneficial applications in cosmetology, pharmacology, and medicine. However, environmental stress in the marine environment can trigger the production of unique secondary metabolites, such as carotenoids. These compounds can also be sustainably produced by symbiotic bacteria. We hypothesized that the soft corals in tropical regions may produce diverse biological secondary metabolites, including carotenoids, both by the host organism and their bacterial symbiont. The unique carotenoids may provide promising biological activity such as antioxidant, UV photoprotector, and antibacterial activities. To this end, we isolated and characterized the carotenoids isolated from the bacterial symbiont of Sinularia sp., a soft coral from Panjang Island, North Java Sea, strain 19. PP.Sc.13. Bacterial identification was performed using DNA barcoding of the 16S rRNA region. Identification of carotenoids was carried out using a spectrophotometer, High-Performance Liquid Chromatography (HPLC), and attenuated total reflection fourier-transformed infrared (ATR-FTIR) spectroscopy. The antioxidant activity was estimated using the diphenylpicrylhydrazyl (DPPH) method, while the Sun Protection Factor (SPF) and % transmission of erythema and pigmentation were determined based on colorimetric methods. The antibacterial activity assay was carried out using the agar diffusion method against two multidrug-resistant bacteria. The bacterial symbiont was identified as Virgibacillus sp. and the carotenoids isolated from this symbiont exhibited significant antioxidant activity and extra sun protection effect, thus categorized as UVA sunblock. Furthermore, the isolated carotenoids exhibited antibacterial activities against Methicillin Resistant-Staphylococcus aureus (MRSA) and Multidrug-resistant (MDR) Escherichia coli. This study provides evidence of the carotenoids produced by the soft coral bacterial symbiont Virgibacillus sp., which may be used as an antioxidant, sun protection, and antibacterial agent. Further investigation of the de novo biological production of carotenoids by Virgibacillus sp. is warranted.     

鼻内镜术后鼻粘膜组织病理学观察

目的 研究鼻内镜手术前后鼻粘膜组织病理学变化。方法 对46例患者术前和术后4个月进行鼻内镜检查和光学显微镜观察。结果 术后4个月炎性细胞、粘膜下结构增厚、水肿、鳞状细胞化生和息肉明显减轻，而杯状细胞、粘膜下层腺体、病理性腺体和纤维化，术后无明显变化（P＞0．05）。与术后患者的临床症状和鼻内镜观察相一致。结论 鼻内镜术后4个月鼻粘膜仍不稳定，且仍处于病变恢复阶段。因此术后随访时间应不少于4个月或更长，以防止复发。