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61.
62.
Andrew K. Fraser Chang Seok Ki Chien‐Chi Lin 《Macromolecular chemistry and physics.》2014,215(6):507-515
Step‐growth PEG‐based microgels are produced via three liquid–liquid two‐phase suspension polymerization systems: i) hexane with surfactants Span80/Tween80; ii) mineral oil with surfactant Pluronic F‐68; and iii) surfactant‐free dextran‐rich aqueous solution. Following short vortexing to create monomer droplets, microgels are polymerized by a visible‐light‐initiated thiol‐ene photo‐click reaction using eosin‐Y as the only photoinitiator. The use of hexane as the organic phase and Span‐80/Tween‐80 as the surfactants leads to PEG microgels with entrapped solvent droplets that dissolve rapidly with time. Microgels polymerized in mineral oil with surfactant Pluronic F‐68 contain no entrapped droplets and are more uniform with smaller sizes. Visible‐light‐cured step‐growth thiol‐ene microgels can also be photopolymerized in a surfactant‐free aqueous two‐phase system. The sizes of the microgels formed in aqueous phase are one order of magnitude smaller than those formed in organic solvent. Dual‐layer microgels are also prepared using two‐step thiol‐ene reactions.
63.
目的观察小儿金翘颗粒联合盐酸克林霉素棕榈酸酯干混悬剂治疗小儿急性扁桃体炎的有效性和安全性。方法选取2014年6月—2017年6月在漯河市中心医院治疗的120例急性扁桃体炎患儿作为研究对象,所有患儿按照入院先后顺序分成对照组和治疗组,每组各60例。对照组患儿温水冲服盐酸克林霉素棕榈酸酯干混悬剂,1袋/次,3次/d;治疗组患者在对照组治疗的基础上开水冲服小儿金翘颗粒,5~7岁儿童7.5 g/次,3次/d;8~10岁儿童7.5 g/次,4次/d;11~12岁儿童10 g/次,3次/d。两组患儿连续治疗1周。观察两组患者的临床疗效,同时比较两组治疗前后的症状积分、主观生活质量问卷(ISLQ)评分、视觉模拟评分法(VAS)、炎性指标水平和不良反应情况。结果治疗后,治疗组的总有效率为96.67%,显著高于对照组的85.00%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者症状积分、ISLQ评分和VAS评分均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组症状积分、ISLQ评分和VAS评分显著低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者血清降钙素原(PCT)、白细胞介素-6(IL-6)和C反应蛋白(CRP)水平均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组炎性指标水平显著低于对照组,两组比较差异具有统计学意义(P0.05)。治疗期间,对照组和治疗组的不良反应发生率分别为13.33%、3.33%,两组比较差异具有统计学意义(P0.05)。结论小儿金翘颗粒联合盐酸克林霉素棕榈酸酯干混悬剂治疗小儿急性扁桃体炎疗效显著,可显著改善患儿体内炎症水平,安全性高,具有一定的临床推广应用价值。 相似文献
64.
目的 探讨甲状腺乳头状癌中央组淋巴结清扫术中使用纳米炭混悬液的意义.方法 甲状腺乳头状癌中央组淋巴结清扫术中使用纳米炭混悬液病例45例(淋巴结示踪组),与同期术中未使用纳米炭混悬液病例49例(空白对照组)在清扫淋巴结数目、手术时间、术中出血量、术后引流量、甲状旁腺功能等方面进行比较.结果 淋巴结示踪组手术时间为(80.47±9.23) min、术中出血量为(35.53±7.43)ml、术后引流量为(71.09±12.18) ml;空白对照组手术时间为(84.65±12.01) min、术中出血量为(35.14±9.08) ml、术后引流量为(69.37±15.38) ml,两组比较差异无统计学意义(P>0.05);淋巴结示踪组术后低钙发生率(4.4%)低于空白对照组(20.4%,P<0.05);淋巴结示踪组术后1d甲状旁腺激素(PTH)水平[(35.36±18.35) ng/L]高于空白对照组[(26.58±15.80) ng/L,P<0.05]、淋巴结示踪组术后1周PTH水平[(37.67±17.29) ng/L]高于空白对照组[(28.06±17.15) ng/L,P<0.01];淋巴结示踪组手术切除淋巴结的数目(9.40±2.35)枚多于空白对照组[(7.86±2.06)枚,P<0.01].结论 术中使用纳米炭混悬液并未增加手术时间、术后引流量及术后并发症,提高了中央组淋巴结清扫的数目,同时有助于识别甲状旁腺并保护甲状旁腺功能. 相似文献
65.
《Journal of plastic surgery and hand surgery》2013,47(5):390-393
AbstractStatic suspension using fascia lata graft is used as a reconstructive procedure against drooping of the mouth corner for treating longstanding facial paralysis. Although it achieves symmetry at rest, movement of the mouth corner at mouth opening is restricted to some extent because it is fixed with fascia lata to the immovable temporal fascia, the parotid fascia, or bones. This was overcome by suspending the mouth corner to the mandibular coronoid process with fascia lata, which enabled a shift of the mouth corner with mouth opening and closure. The nine patients discussed in this study were operated on since 1994 for longstanding facial paralysis and followed-up for over 1.5 years. As in conventional static suspension, the fascia lata was harvested and split into two bands. Next, one semi-oval fascial loop was inserted around the paralysed part of the mouth and tied with another fascial band at the mouth corner, which was looped to the mandibular coronoid process. The suspended fascia lata graft was relaxed with anteroinferior movement of the coronoid process at mouth opening, enabling the mouth corner to shift inferiorly. The mouth corner returned to its original position at mouth closure, and the nasolabial fold deepened during mastication. No limitation in mouth opening was observed. Suspension of the mouth corner to the mandibular coronoid process provided a dynamic element, thereby restoring a near-normal shift. The procedure is considered as an alternative for reconstructing the malar region of patients with facial paralysis and in whom dynamic reconstruction is not indicated. 相似文献
66.
Nadjet Serradj Florence Picquet Marc Jamon 《The European journal of neuroscience》2013,38(9):3281-3291
This study aimed to evaluate the long‐term consequences of early motor training on the muscle phenotype and motor output of middle‐aged C57BL/6J mice. Neonatal mice were subjected to a variety of motor training procedures, for 3 weeks during the period of acquisition of locomotion. These procedures are widely used for motor training in adults; they include enriched environment, forced treadmill, chronic centrifugation, and hindlimb suspension. At 9 months, the mice reared in the enriched environment showed a slower type of fibre in slow muscles and a faster type in fast muscles, improved performance in motor tests, and a modified gait and body posture while walking. The proportion of fibres in the postural muscles of centrifuged mice did not change, but these mice showed improved resistance to fatigue. The suspended mice showed increased persistence of immature hybrid fibres in the tibialis, with a slower shift in the load‐bearing soleus, without any behavioural changes. The forced treadmill was very stressful for the mice, but had limited effects on motor output, although a slower profile was observed in the tibialis. These results support the hypothesis that motor experience during a critical period of motor development shapes muscle phenotype and motor output. The different impacts of the various training procedures suggest that motor performance in adults can be optimized by appropriate training during a defined period of motor development. 相似文献
67.
目的分析外源一氧化碳(CO)对白桦悬浮细胞生长和三萜累积的影响。方法在白桦悬浮细胞培养的第8天添加5、10、20、30μmol/L的CO供体高铁血红素处理0.25~8 d,采用高效液相色谱法、比色法和实时荧光定量PCR方法分析白桦三萜含量及其合成关键酶基因的表达。结果除20和30μmol/L CO处理2 d后显著降低白桦悬浮细胞干质量外,CO处理未对白桦悬浮细胞干质量产生显著影响。除30μmol/L CO处理提高pH值和丙二醛含量外,CO处理未对pH值和丙二醛含量产生显著影响。CO处理不同程度地增加了三萜、白桦酯醇和齐墩果酸含量,其中,30μmol/L CO处理1 d时三萜积累量达最大值,为同期对照的1.3倍;10μmol/L CO处理4 d时白桦酯醇含量达最高值,为对照的1.5倍;10μmol/L CO处理2 d时齐墩果酸含量达最高值,为对照的4.2倍。三萜合成关键酶FPPS、LUS、CAS1、CAS2和β-AS基因的实时荧光定量PCR检测结果进一步证实了CO对白桦三萜累积的促进作用。结论 CO处理促进了白桦悬浮细胞中三萜的合成。 相似文献
68.
Sita M. Damaraju Benjamin R. Mintz J. Genevieve Park Ankur Gandhi Sunil Saini Joseph A. Molnar 《International wound journal》2022,19(1):188-201
Clinical application of skin substitute is typically a two-stage procedure with application of skin substitute matrix to the wound followed by engraftment of a split-thickness skin graft (STSG). This two-stage procedure requires multiple interventions, increasing the time until the wound is epithelialised. In this study, the feasibility of a one-stage procedure by combining bioengineered collagen-chondroitin-6-sulfate (DS1) or decellularised fetal bovine skin substitute (DS2) with autologous skin cell suspension (ASCS) in a porcine full-thickness wound healing model was evaluated. Twelve full-thickness excisional wounds on the backs of pigs received one of six different treatments: empty; ASCS; DS1 with or without ASCS; DS2 with or without ASCS. The ASCS was prepared using a point-of-care device and was seeded onto the bottom side of DS1, DS2, and empty wounds at 80 000 cells/cm2. Wound measurements and photographs were taken on days 0, 9, 14, 21, 28, 35, and 42 post-wounding. Histological analysis was performed on samples obtained on days 9, 14, 28, and 42. Wounds in the empty group or with ASCS alone showed increased wound contraction, fibrosis, and myofibroblast density compared with other treatment groups. The addition of ASCS to DS1 or DS2 resulted in a marked increase in re-epithelialisation of wounds at 14 days, from 15 ± 11% to 71 ± 20% (DS1 vs DS1 + ASCS) or 28 ± 14% to 77 ± 26 (DS2 vs DS2 + ASCS) despite different mechanisms of tissue regeneration employed by the DS used. These results suggest that this approach may be a viable one-stage treatment in clinical practice. 相似文献
69.
目的 研究中药复方-强骨抗萎方(QGKWP)对尾吊大鼠骨代谢的影响.方法 21只雄性SD大鼠随机分为对照组(Con),尾吊组(TS)和强骨抗萎方处理组(QGKWP),分别填喂2.5 mL生理盐水或30mg/g中药复方,早晚各1次.每周利用双能X射线吸收测定法检测其骨密度.实验28天后,取血清测定碱性磷酸酶(ALP)、骨碱性磷酸酶(BALP)、骨γ碳氧谷氨酸蛋白(BGLAP)和脱氧吡啶(DPD).同时检测承重骨力学性能、骨干重和骨灰重.免疫组化检测骨Ⅰ型胶原(type Ⅰ collagen),骨钙素(osteocalcin)和骨桥蛋白(osteopontin)含量.结果 与尾吊组相比,强骨抗萎方组股骨、胫骨和腰椎骨密度显著升高,血清ALP和BGLAP表达增加.QGKWP还能明显升高尾吊大鼠股骨Ⅰ型胶原和骨桥蛋白的表达.结论 强骨抗萎方可部分逆转由尾吊引起的失重效应,在对抗骨丢失方面有潜在应用价值. 相似文献
70.
目的探讨猪肺表面活性物质(PS)联合布地奈德混悬液气管内滴入治疗新生儿胎粪吸入综合征(MAS)的临床效果。方法采用前瞻性研究法,将70例MAS新生儿随机分成治疗组与对照组(n=35)。对照组常规给予气管内滴入PS(100 mg/kg)治疗,治疗组在此基础上加用布地奈德(0.25 mg/kg)治疗。结果治疗组在治疗后12 h需重复使用PS的比例明显低于对照组(P0.05)。治疗组在治疗后6 h、12 h、24 h动脉氧分压与吸入氧浓度比值(Pa O_2/Fi O_2)、经皮血氧饱和度(Tc Sa O_2)、动脉血氧分压(Pa O_2)、动脉血二氧化碳分压(Pa CO_2)的改善情况明显优于对照组(P0.05)。治疗后48 h胸片显示治疗组肺部炎症吸收明显优于对照组(P0.05);治疗组并发症的发生率明显低于对照组(P0.05),平均住院时间也较对照组明显缩短(P0.01)。结论与单用PS比较,PS联合布地奈德混悬液气管内滴入治疗新生儿MAS能更好改善血气指标和临床症状,缩短住院时间,减少并发症。 相似文献