首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   244篇
  免费   10篇
  国内免费   9篇
耳鼻咽喉   1篇
妇产科学   1篇
基础医学   15篇
口腔科学   2篇
临床医学   6篇
内科学   18篇
神经病学   50篇
特种医学   9篇
外科学   10篇
综合类   47篇
预防医学   43篇
眼科学   3篇
药学   44篇
  1篇
中国医学   12篇
肿瘤学   1篇
  2022年   5篇
  2021年   5篇
  2020年   4篇
  2019年   17篇
  2018年   13篇
  2017年   7篇
  2016年   10篇
  2015年   4篇
  2014年   13篇
  2013年   10篇
  2012年   17篇
  2011年   27篇
  2010年   26篇
  2009年   22篇
  2008年   16篇
  2007年   22篇
  2006年   10篇
  2005年   9篇
  2004年   8篇
  2003年   7篇
  2002年   7篇
  2001年   2篇
  2000年   1篇
  1982年   1篇
排序方式: 共有263条查询结果,搜索用时 15 毫秒
31.
SPSS在高等数学成绩分析中的应用   总被引:2,自引:0,他引:2  
利用SPSS对高等数学成绩进行统计分析,得到不同学院、不同教师所教班级以及不同班级之间的成绩的对比结果。分析过程表明,SPSS软件对学生成绩进行分析是非常方便易用的。  相似文献   
32.
Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one on a hypocaloric diet (HD) and the other not on a hypocaloric diet. Weight, height and BMI data were collected concurrently with 5-ml blood sampling of each subject. BDNF levels were measured with a sandwich-ELISA. The blood sample was obtained a minimum of one month after the exposure to dietary intervention. Serum BDNF levels were significantly higher in patients on the HD (p=0.023). Additional research examining the interaction among patterns of nutritional food behavior and underlying physiopathology may result in insights upon which evidence-based decisions regarding dietary interventions can be made in people identified with major psychiatric disorders, such as schizophrenia.  相似文献   
33.
Post-mortem studies have demonstrated a decreased number of glia, reduced glial density, and a decreased glia/neuron ratio in different brain areas of patients diagnosed with a major depressive disorder (MDD). Researchers have therefore suggested that neurotrophic growth factor systems might be involved in the aetiology of MDD. This study aimed to test whether glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor beta family, in serum was associated with MDD. Serum concentrations were measured in MDD patients before treatment (n=76), after 8 weeks of antidepressant treatment (n=39), and in control subjects (n=50) using a sandwich ELISA method. Serum GDNF was significantly lower in MDD patients before treatment than in control subjects (P<0.001). From baseline to remission after 8 weeks of treatment, the increase in serum GDNF was statistically significant (P<0.001). The present study suggests that lower serum GDNF might be involved in the pathophysiology of MDD and antidepressant treatment increases the GDNF in MDD.  相似文献   
34.
35.
本文主要是阐述SPSS(StatistitalPackageforSocialSciences)这一社会科学统计软件在外语教学研究中的重要作用。随着对外语教学研究的科学性和实证性的要求不断提高,外语教学研究的水平不再停留在汉字的综述上,而是要求研究更为科学化,增强实用性和可信数据化、明朗化,以便增强后继研究的可行性。作者在文中用调查和文献综述法阐明SPSS这一社会科学统计软件使外语教学研究更为科学化,增强实用性和可信数据化、明朗化,以便增强后继研究的可行性等不可低估的作用。  相似文献   
36.
利用SPSS统计分析软件处理正交(均匀)设计数据   总被引:1,自引:0,他引:1  
利用SPSS(Statistical Package for the Social Science)统计分析软件对正交(均匀)设计所得数据进行计算、统计及绘图,既简便、快捷,又直观、清晰,可以作为数据统计处理的理想方法。  相似文献   
37.

Objectives

The aim of this study was to implement and evaluate the outcomes of chemotherapy counselling based on the “Managing Patients on Chemotherapy” module on self-esteem and psychological affect (anxiety, depression) of cancer patients by pharmacists in ten selected government hospitals in Peninsular Malaysia.

Methods

A randomized control trial was conducted among 2120 cancer patients from April 2016 to January 2017 in ten selected government hospitals in Peninsular Malaysia. Cancer patients were randomly assigned to intervention and control groups. The intervention group received chemotherapy counselling by pharmacists based on the “Managing Patients on Chemotherapy” module. The outcomes were assessed at baseline, 1st, 2nd and 3rd follow-ups after counselling. In the course of data analysis; independent sample t-test, chi-square and two-way repeated measures ANOVA were conducted.

Results

Mean scores of self-esteem in the intervention group had significant difference in comparison with those of the control group in the 1st, 2nd and 3rd follow-ups after counselling (P?<?0.0001). Also, among those with depression and anxiety at baseline, there was reduction in depression and anxiety scores after the 1st, 2nd and 3rd follow-ups after counselling (p?<?0.05).

Conclusion

Repetitive counselling by pharmacists based on the “Managing Patients on Chemotherapy” module had positive effect on improving self-esteem and psychological affect of cancer patients undergoing chemotherapy in Peninsular Malaysia.

Practice implications

This module can be used for all Malaysian cancer patients undergoing chemotherapy to improving self-esteem and psychological affect.  相似文献   
38.

Objective

Online cognitive-behavioral therapy (iCBT) is effective in supporting patients’ self-management. Since iCBT differs from face-to-face CBT on several levels, proper training of therapists is essential. This paper describes the development and evaluation of a therapist training based on theoretical domains that are known to influence implementation behavior, for an iCBT for chronic pain.

Methods

The training consists of 1.5?days and covers the implementation domains “knowledge”, “skills”, “motivation”, and “organization”, by focusing on the therapy’s rationale, iCBT skills, and implementation strategies. Using an evaluation questionnaire, implementation determinants (therapist characteristics, e-health attitude, and implementation domains) and iCBT acceptance were assessed among participants after training.

Results

Twenty-two therapists participated, who generally showed positive e-health attitudes, positive implementation expectations, and high iCBT acceptance. Organizational aspects (e.g., policy regarding iCBT implementation) were rated neutrally.

Conclusions

An iCBT therapist training was developed and initial evaluations among participants showed favorable implementation intentions.

Practice implications

Therapists’ positive training evaluations are promising regarding the dissemination of iCBT in daily practice. Organizational support is vital and needs to be attended to when selecting organizations for iCBT implementation.  相似文献   
39.

Introduction

Bronchiolitis Obliterans Syndrome (BOS) is a debilitating disease with limited treatment options that threatens both the quality of life and long-term survival of lung transplant (LTx) recipients. This retrospective longitudinal case–control study was performed to compare the long-term functional evolution of LTx recipients with and without BOS.

Methods

Twenty-four LTx recipients with BOS (BOS=Cases) and 24 without BOS (NON-BOS=Controls) were selected and individually matched according to age, gender, diagnosis and LTx characteristics. Measurements of 6-minute walking distance (6MWD), symptoms of dyspnea (BORG CR-10 scale), and comprehensive pulmonary function testing were performed before LTx and at annual follow-up assessments after LTx.

Results

Peak FEV1 after LTx was similar in both groups [FEV1 (% predicted) 101 ± 25 vs. 101 ± 31, p = 0.96] and BOS diagnosis in cases was established 3.6 ± 2.5 years after LTx. At the final follow-up assessment (6.5 ± 3.2 years after LTx) FEV1 (% predicted) was 86 ± 34 in NON-BOS vs. 44 ± 17 in BOS (p < 0.001). Evolution of 6MWD was different between groups (group by time interaction: p = 0.002). Borg dyspnea scores were also significantly different between groups at the final evaluation (NON-BOS 3.3 ± 1.7 vs. BOS 5.0 ± 2.2; p = 0.024).

Conclusions

We observed gradual reductions in functional exercise capacity and increasing symptoms of dyspnea in patients who developed BOS after LTx. As such, prospective studies seem warranted to explore whether rehabilitative interventions might be useful to improve symptoms and slow down deterioration of exercise capacity in these patients from the onset of BOS.  相似文献   
40.
Human leukocyte antigen (HLA) G and E, programmed cell death 1 ligand 1 (PD-L1), IL-10 and TGF-β are proteins involved in failure of the antitumor immune response. We investigated the expression of these immunomodulatory mediators in oral precancerous lesions (oral leukoplakia-OL; n = 80) and whether these molecules were related to the risk of malignant transformation. Samples of normal mucosa (n = 20) and oral squamous cells carcinoma (OSCC, n = 20) were included as controls. Tissue and saliva samples were analyzed by immunohistochemistry and ELISA respectively. Fifteen OL samples showed severe dysplasia (18.7%) and 40 samples (50%) presented combined high Ki-67/p53. Irrespective of the degree of epithelial dysplasia and the proliferation/apoptosis index of OL, the expression of HLA-G, -E, PD-L1, IL-10, TGF-β2 and -β3 was higher to control (P < 0.05) and similar to OSCC (P > 0.05). The number of granzyme B+ cells in OL was similar to control (P = 0.28) and lower compared to OSCC (P < 0.01). Salivary concentrations of sHLA-G, IL-10 and TGF-β did not allow for a distinction between OL and healthy individuals. Overexpression of immunosuppressive mediators in the OL reflects the immune evasion potential of this lesion, which is apparently independent of at cytological and proliferation/apoptosis status.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号