四环牌清洗消毒剂杀灭微生物效果的试验观察

目的 以载体定量试验方法观察四环牌清洗消毒剂杀灭微生物效果。方法 用有效氯含量不同的四环牌清洗消毒剂分别作用于枯草杆菌黑色变种芽胞和大肠埃希菌，不同时间观察其实验室的灭菌效果。结果 有效氯含量为53．95g／L、21．58g／L和10．29g/L的该清洗消毒剂对布片上枯草杆菌黑色变种芽胞100％的杀灭时间分别为15min、20min和30min；有效氯含量为0．5395g／L、0．4316g／L和0．3996g／L的该清洗消毒剂对布片上大肠埃希菌100％的杀灭时间分别为3min、7min和7min。结论 四环牌清洗消毒剂杀灭枯草杆菌黑色变种芽胞和大肠埃希菌可获得满意的效果。     

Proteus syndrome: association with gingival hyperplasia

A 9-year old Black boy with gigantism of the hands and feet, and recurrent gingival hyperplasia, diagnosed as Proteus syndrome is presented. The oral manifestations of this syndrome are described. To the best of our knowledge, this is the first reported case of gingival hyperplasia associated with Proteus syndrome.     

Pathology of Lipomatous Lesions in Proteus Syndrome

Proteus syndrome is an extremely rare, complex hamartomatous disorder with markedly variable clinical expression. We present a case of Proteus syndrome with multiple disfiguring soft tissue masses that were present since early childhood. The lesions involved predominantly the right side of the body and included scoliosis, macrodactyly, and limited hyperostosis in the right foot. There was no evidence of cranial or skin lesions. The patient underwent multiple resections of soft tissue masses, including an amputation of the right foot because of severe gait disturbance. All specimens exhibited lipomatous lesions that were probably hamartomatous rather than neoplastic. She carried a diagnosis of neurofibromatosis for more than a decade, but a re-evaluation of clinical features and pathological findings prompted the diagnosis of Proteus syndrome. We believe that a more informed evaluation of the pathology material may help to identify this rare entity. Received May 6, 1997; accepted October 28, 1997.     

伤口与尿液中奇异变形菌的耐药性对比研究

目的 比较两种主要临床标本检出的奇异变形菌(PMI)耐药性,为合理应用抗菌药物提供依据.方法 收集住院患者尿液和伤口分泌物中的PMI进行鉴定和药敏试验.结果 PMI分离率以尿液最高占41.2％;伤口分泌物占24.7％,两者之和为65.84％;尿道和伤口的PMI药物敏感性不同,除了头孢类之外,尿液PMI对抗菌药物的耐药率更高.结论 尿道和伤口是PMI感染的主要部位,应加强对尿道和伤口的管理;临床上经验用药时,应区别对待尿道和伤口的PMI感染.     

奇异变形菌医院感染的耐药性变迁及临床对策

目的 分析临床分离的奇异变形菌的耐药性及其变迁,为临床合理用药提供依据.方法 对医院2008年1月-2010年12月住院患者各种标本中分离到的奇异变形菌385株,采用17种抗菌药物进行药敏试验;并比较3年的变迁情况.结果 分离到的奇异变形菌对亚胺培南/西司他丁的敏感率最高为100.0％,对美罗培南、哌拉西林/他巴唑、氨曲南、头孢曲松、头孢匹美、头孢他啶、妥布霉素的敏感率均＞90.0％;对呋喃妥因、磺胺甲噁唑/甲氧苄啶的耐药率均＞50.0％,头孢哌酮/舒巴坦为0.3％,对氨苄西林/舒巴坦、环丙沙星、左氧氟沙星耐药率呈升高趋势.结论 医院感染奇异变形菌分离率较高,对多种抗菌药物具有较高敏感性,但对某些抗菌药物耐药率呈上升趋势,应加强监测,根据药敏试验合理选用抗菌药物.     

Surgical treatment of macrodactyly in Proteus syndrome

Proteus syndrome is a rare congenital disorder composed of a wide variety of deformities including macrodactyly of the foot. A dearth of information on the surgical management of macrodatyly in Proteus syndrome exists in the literature. In this report, we present our experience in the surgical treatment of two patients with Proteus syndrome, both of whom suffered from disordered gait and problems with finding well-fitting shoes. By resection of the most enlarged ray, shortening of adjacent enlarged rays, debulking of soft tissue and ray transposition, both patients gained a fairly normal gait and were able to wear normal shoes.     

Pathology of Osseous and Genitourinary Lesions of Proteus Syndrome

A male patient followed from the age of 3 to 25 years was eventually diagnosed as having Proteus syndrome. He was born with linear epidermal nevi of the neck and forearm and presented with macrodactyly of the right hand and progressive hemihypertrophy of the right lower limb recurring after multiple reduction operations. The bone ends showed disorderly overgrowth of hyaline and fibrocartilage mixed with collagen and bone, and early differential diagnoses included Ollier's disease. The child also had vertebral anomalies, scoliosis, a bony protrusion of the cranial vertex, and strabismus. In the second decade he developed gyriform swelling of the soles, retinopathy, bilateral papillary cysts of the epididymis, and a giant cyst of the left kidney with complex glandular foci. At 22 years a 3-cm meningioma containing adipose tissue was resected, and at 24 years a 3-cm cellular nodule of the rete testis with hyperchromatic foci, probably an adenoma, was removed. The features of Proteus syndrome were those of hyperplasia and neoplasia of mostly mesodermal tissues. Unlike other reported cases, overgrowth of a finger recurred at 25 years.     

Role of internal fixation in infection of open fractures: studies with Staphylococcus aureus and Proteus mirabilis

Studies of infections in open fractures are described. The hamster was chosen as the experimental model. Osteotomies of the femur were created with an osteotomy saw. Some osteotomies were left to heal and others were fixed with an 0.9 mm K-wire. The infection rates in fixed and unfixed fractures were compared. The first group of hamsters with fixed and unfixed osteotomies was returned to cages with open wounds. There was no difference in the infection rate at 2 weeks. The second group was deliberately contaminated with Staphylococcus aureus and then returned to cages with open wounds. In this group, the infection rate at 2 weeks was lower in the internally-fixed fractures than in the unfixed fractures. The third group was deliberately contaminated with the gram negative organism Proteus mirabilis. In these animals, the infection rate was increased in the presence of the internal fixation device. The fourth group was deliberately contaminated with both Staphylococcus aureus and Proteus mirabilis. The infection rate in these animals was very high; Proteus was recovered from those animals with internal fixation and Staphylococcus was recovered from those animals without internal fixation. These studies in the hamster document the usefulness of this animal as an inexpensive and reproducible model for studying infection of open fractures. The hamsters tolerated the procedure well, and wound and fracture healing progressed satisfactorily.     

Rheumatoid arthritis and proteus: a possible aetiological association

Summary The presence of specific anti-Proteus antibodies in active, rheumatoid arthritis (RA) patients, has been demonstrated by four different techniques: indirect bacterial agglutination, ELISA, Western blotting and immunofluorescence. Furthermore, anti-HLA-DR4 tissue typing sera have been shown to bind to Proteus microorganisms, thereby suggesting some molecular similarity or cross-reactivity between bacteria and HLA antigens. The concept is proposed that Proteus-reactive arthritis occurs during active phases of RA and tissue damage is mediated through immunological activity involving HLA antigens.     

Recurrent meningitis: a case report

A 25-month-old girl is described who experienced three successive attacks of purulent meningitis due to Proteus mirabilis. Third generation cephalosporins were employed as treatment. Crainal radiography and computed tomography revealed a malformation, in the form of an epidermoid cyst, in a central occipital position; small cerebellar abscesses were also present. The lesion was removed by surgery which led to a complete recovery.