82例应力性骨折影像学诊断回顾性分析

目的：研究影像学在诊断应力性骨折中的应用。方法：选取2013年1月—2017年12月南京医科大学第一附属医院收治的82例保有影像学资料并诊断明确的应力性骨折患者作为研究对象，对患者影像学资料进行回顾性分析，并比较分析X线、CT、MRI对应力性骨折的诊断准确率及漏诊的原因。结果：82例应力性骨折患者的男女比例为1∶1.9，平均年龄为49.77岁；病变多累及下肢骨及中轴骨，胫骨为最常见累及部位；X线、CT、MRI的诊断准确率依次升高，X线、CT的初诊漏诊与MRI分级之间的关系无统计学意义；X线及CT图像中骨膜反应易被漏诊。结论：应力性骨折的影像学诊断应结合临床病史及好发部位，早期诊断应力性骨折首选MRI，注重X线及CT中骨膜反应及软组织情况以减少漏诊率。     

腹腔镜胆囊切除术治疗胆囊结石合并胆总管结石患者的近远期效果分析

目的分析腹腔镜胆囊切除术治疗胆囊结石合并胆总管结石患者的近远期效果。方法选取2017年1月至2018年1月我院收治的78例胆囊结石合并胆总管结石患者为研究对象,采用随机数字法将其分为传统组和腹腔镜组,各39例。传统组给予开腹胆囊切除术联合胆总管切开取石术治疗,腹腔镜组给予腹腔镜胆囊切除术治疗。比较两组手术前、后的疼痛缓解情况、应激反应指标、临床治疗效果、并发症发生情况及术后1年的复发率。结果手术后1个月,两组的NRS评分明显降低,且腹腔镜组明显低于传统组(P<0.05)。手术后,腹腔镜组的CRP及IL-6水平均低于传统组(P<0.05)。腹腔镜组的临床治疗总有效率为94.87%,明显高于传统组的71.79%(P<0.05)。腹腔镜组的并发症总发生率为7.69%,明显低于传统组的33.33%(P<0.05)。腹腔镜组术后1年的复发率明显低于传统组(P<0.05)。结论腹腔镜胆囊切除术治疗胆囊结石合并胆总管结石患者的近远期效果更加显著,值得临床推广应用。     

Unemployment,employment precarity,and inflammation

Unemployment has been associated with poorer health, but few studies have examined the biological mechanisms that confer these health decrements. Further, no studies to date have examined differences across employment groups to consider whether employment (in whatever means) is preferential in terms of health. The present study utilised secondary data from Understanding Society: The Household Longitudinal Survey during the aftermath of the recent global recession. Two markers of peripheral inflammation: C-reactive protein (CRP) and fibrinogen were assessed across employment groups (unemployed; permanent, temporary, and self-employed), controlling for individual, socio-demographic and health variables to give greater context to our understanding of how employment status influences health. After controlling for relevant confounds, unemployment was associated with higher levels of fibrinogen but not CRP. Subsequent analyses of employment subgroup revealed the temporary employed have similar levels of fibrinogen to the unemployed, and may therefore be at a similar health disadvantage. The findings confirm that unemployment is associated with increases in one marker of peripheral inflammation, but that this health protection is not conferred to those in precarious employment.     

Literacy-Free 12 Step Expressive Arts Curriculum Enhances Engagement and Treatment Outcomes for Dually Diagnosed Substance Use and Mental Health Disorders

ABSTRACT

This study evaluated the efficacy of the Literacy-Free 12 Step Expressive Arts Therapy© curriculum in enhancing personal change and treatment outcomes for populations dually diagnosed with substance use and mental health disorders. It supplemented standard rehabilitation treatment for 47 individuals in a U.S. facility by incorporating 12 Step guidelines, cognitive behavioral therapy, rational emotive behavior therapy, and expressive arts activities. Pre-session and post-session participant ratings revealed positive increases for commitment to recovery, attitude toward making lifestyle changes, and hopefulness. Compared to 101 inpatients at the same facility, curriculum participants evidenced less drop-out, higher treatment completion, and greater personal investment in recovery.     

甲泼尼龙琥珀酸钠对自身免疫性肺气肿模型大鼠氧化应激和抗内皮细胞抗体的影响

目的:研究甲泼尼龙琥珀酸钠对自身免疫性肺气肿模型大鼠氧化应激和抗内皮细胞抗体(AECA)的影响。方法:将雄性SD大鼠随机分为对照组、模型组和干预组,每组8只。除对照组大鼠腹腔注射等体积的完全弗氏佐剂外,模型组和干预组大鼠均腹腔注射体外培养的人脐静脉内皮细胞+完全弗氏佐剂混合物以复制自身免疫性肺气肿模型;造模给药后第2天,干预组大鼠腹腔注射甲泼尼龙琥珀酸钠10 mg/(kg·d),对照组和模型组大鼠均腹腔注射等体积的生理盐水,每日1次,连续21 d。末次给药后,取各组大鼠右肺组织制作石蜡切片并行苏木精-伊红染色,观察肺组织病理变化,测量单位面积内的肺泡数(MAN)和内衬间隔(MLI);检测左肺肺泡灌洗液(BALF)中丙二醛(MDA)、还原型谷胱甘肽(GSH)含量和超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性,以及BALF和血清中AECA含量。采用Pearson分析模型组大鼠BALF中AECA与MDA、GSH、SOD、GSH-Px的相关性。结果:与对照组比较,模型组大鼠肺组织可见明显的肺气肿病理变化,其MAN显著减少,MLI显著延长(P<0.01);BALF中GSH含量和SOD、GSH-Px活性均显著降低,BALF中MDA含量以及BALF、血清中AECA含量均显著升高(P<0.01)。与模型组比较,干预组大鼠肺组织的肺气肿病理变化明显改善,其MAN显著增加,MLI显著缩短(P<0.01);BALF中GSH含量和SOD、GSH-Px活性均显著升高;BALF中MDA含量以及BALF、血清中AECA含量均显著降低(P<0.01)。模型组大鼠BALF中的AECA与MDA呈正相关(r=0.710,P<0.05),与GSH、SOD、GSH-Px呈负相关(r=-0.754、-0.781、-0.736,P<0.05)。结论:甲泼尼龙琥珀酸钠可能通过减轻氧化应激反应、抑制AECA的表达,从而达到预防自身免疫性肺气肿的目的。     

应力性骨折早期影像学分析

目的研究早期应力性骨折(SF)的临床、影像学诊断,以便早发现、早治疗,减少SF所致的伤残,以保持提升我军战斗力。方法回顾性分析6年我院所确诊310例SF,对临床(年龄、性别、职业、部位、病程)、影像学表现进行了细致分析。结果 18²4岁占80%,男性占94%,全部为军人,部位胫骨占61%,胫、股骨SF中初期发病部位全为后内侧持重部,就诊时多在224岁占80%,男性占94%,全部为军人,部位胫骨占61%,胫、股骨SF中初期发病部位全为后内侧持重部,就诊时多在2³周左右;影像学表现中,X线早期表现为损伤骨皮质部13周左右;影像学表现中,X线早期表现为损伤骨皮质部1³ mm小丘状改变或薄层状骨膜增生,此表现在SF患者就诊33 mm小丘状改变或薄层状骨膜增生,此表现在SF患者就诊3¹4 d可出现;CT可发现复杂骨或重叠骨骨折或骨痂形成;MRI对于软组织损伤、骨膜及骨髓充血水肿很敏感,SF患者就诊114 d可出现;CT可发现复杂骨或重叠骨骨折或骨痂形成;MRI对于软组织损伤、骨膜及骨髓充血水肿很敏感,SF患者就诊1³ d MRI就能诊断。结论 SF的发病年龄、性别、职业、部位基本同教科书及文献所述;影像学表现与教科书及文献所述有所不同,我们认为X线可早期发现SF,且发现率较高(90%以上),MRI可作为SF的补充或早期检查手段;我们将SF重新定义为应力性损伤(肌肉、骨外膜损伤时即归为应力性之内),影像学分为六型,对于早期诊治有大的意义。