首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   37392篇
  免费   2090篇
  国内免费   1907篇
耳鼻咽喉   32篇
儿科学   412篇
妇产科学   112篇
基础医学   2838篇
口腔科学   38篇
临床医学   4437篇
内科学   9625篇
皮肤病学   28篇
神经病学   4098篇
特种医学   1918篇
外科学   3338篇
综合类   7356篇
预防医学   853篇
眼科学   238篇
药学   3479篇
  9篇
中国医学   2488篇
肿瘤学   90篇
  2024年   49篇
  2023年   262篇
  2022年   669篇
  2021年   851篇
  2020年   805篇
  2019年   614篇
  2018年   705篇
  2017年   767篇
  2016年   924篇
  2015年   1090篇
  2014年   2072篇
  2013年   2161篇
  2012年   2025篇
  2011年   2314篇
  2010年   2101篇
  2009年   2111篇
  2008年   2280篇
  2007年   2361篇
  2006年   2289篇
  2005年   1996篇
  2004年   1712篇
  2003年   1608篇
  2002年   1356篇
  2001年   1216篇
  2000年   1046篇
  1999年   878篇
  1998年   726篇
  1997年   686篇
  1996年   470篇
  1995年   464篇
  1994年   371篇
  1993年   283篇
  1992年   289篇
  1991年   282篇
  1990年   207篇
  1989年   159篇
  1988年   166篇
  1987年   129篇
  1986年   114篇
  1985年   145篇
  1984年   114篇
  1983年   61篇
  1982年   80篇
  1981年   63篇
  1980年   62篇
  1979年   49篇
  1978年   55篇
  1977年   37篇
  1976年   36篇
  1975年   23篇
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
11.
电针对沙鼠急性脑缺血再灌注后神经原损伤的保护作用   总被引:9,自引:0,他引:9  
本实验利用沙鼠急性脑缺血再灌注模型,研究电针对脑缺血及再灌注各期脑电活动的影响及组织病理学的改变。结果表明:缺血10mln,脑电幅度受到严重抑制,甚至变平坦,总功率大大下降,再灌注后总功率难以恢复,在120min时仅恢复到缺血前的27.39±11.31%,以后即不再进一步恢复,电针组动物缺血10min再灌注后,脑电的恢复明显比对照组快,120min时恢复至缺血前的71.45±16.46%(P<0.01),240min时继续恢复至缺血前的75.27±18.43%。同时电针能明显减轻缺血10min后再灌注24小时的神经原缺血性损伤。结果提示:电针对急性脑缺血引起的神经原损伤具有保护作用,并能促进脑功能的恢复。  相似文献   
12.
31P, 1H and lactate spectroscopic imaging was used to evaluate the effects of hypothermia on focal cerebral ischemia produced by middle cerebral artery occlusion. The effects on high energy phosphate metabolism, pH, lactate and NAA were investigated in 24 spontaneously hypertensive rats subjected to either permanent or transient ischemia. Under either normothermic (37.5°C) or hypothermic (32°C) conditions, with permanent 6-h occlusion, there was little difference between groups in either the NMR measurements or the volume of infarction. In animals that underwent 3 h of ischemia followed by 12 h of reperfusion, the ischemic changes in lactate, pH, NAA, and high-energy phosphate returned toward control values, and there was a protective effect of hypothermia (infarct volume of 211 ± 26 and 40 ± 14 mm3 in normothermic and hypothermic groups, respectively). Thus, hypothermia did not ameliorate the changes in lactate, pH, NAA, or high energy phosphate levels occurring during ischemia, however, during reperfusion there was an improvement in both the recovery of these metabolites and pathological outcome in hypothermic compared with normothermic animals.  相似文献   
13.
The best test presently available to ascertain residual viability within an infarct-related area involves the use of fluorine-18 fluorodeoxyglucose (FDG) to detect the persistence of some cellular metabolism. Rest reinjection of thallium-201 is a less accurate alternative but is easy to perform. Iodinated fatty acids, which are used with standard gamma cameras, are proposed as markers of cellular metabolism. This study was performed to assess the value of 16-iodo-3-methyl-hexadecanoic acid (MIHA) as a marker of the residual cellular metabolism by comparison with FDG in patients with a recent myocardial infarction, and to evaluate its contribution compared with the201Tl stress-redistribution-reinjection technique. Stress-redistribution-reinjection201T1 imaging, rest MIHA imaging and glucoseloaded FDG imaging were performed in 22 patients with recent myocardial infarction. Out of the 628 myocardial segments obtained from the left ventricular analysis, 400 were hypoperfused (relative uptake <0.75 of maximum uptake on stress201T1 imaging), 177 of which were severely hypoperfused (relative uptake <0.50). Receiver operating characteristic (ROC) curves for predicting metabolic myocardial viability with FDG were derived from the results in respect of (a)201T1 activity during exercise, redistribution and reinjection and (b) MIHA up-take, using the two FDG thresholds most commonly considered to define metabolic viability (0.50 and 0.60). Analysis of the 400 hypoperfused segments demonstrated that201T1 reinjection was the most accurate test in predicting the presence of myocardial viability (area under the ROI curves=0.85 and 0.86 at the 0.50 and 0.60 FDG thresholds, respectively;P<0.05 vs other tests). The global predictive values of MIHA and201T1 reinjection were, respectively, 0.87 and 0.89 at the 0.50 FDG threshold (NS), and 0.82 and 0.87 at the 0.60 FDG threshold (NS). When only the 177 severely hypoperfused segments were considered,201T1 reinjection remained the most accurate test (accuracy 0.84 at the 0.50 FDG threshold and 0.82 at the 0.60 FDG threshold), while the accuracy of MIHA decreased significantly (0.78 at the 0.50 FDG threshold and 0.73 at the 0.60 FDG threshold,P<0.05 vs201T1 reinjection). In all circumstances, MIHA was less specific than201T1 reinjection for the detection of metabolic viability. In conclusion, in patients with recent myocardial infarction, MIHA accurately detects the persistence of metabolic viability, but is not superior to201T1.  相似文献   
14.
15.
缺血性脑血管病患者的血脂水平   总被引:4,自引:0,他引:4  
目的分析缺血性脑血管病(ICVD)患者的血脂水平,为今后预防保健及康复干预决策的制定提供依据。方法在佛山市第一人民医院病案数据库中检索1991-2004年诊断为ICVD的病例共2886例,其中2000-2004年ICVD患者共1430例为一亚组,以我院同时期保健科随机选取的400名健康体检人群为对照组,记录血脂情况,进行对照分析。结果血TC、TG和LDL—C水平ICVD患者组明显高于健康体检人群,差异有统计学意义。男女两性血脂水平均随年龄增加而逐渐增高,50岁以上女性血脂水平明显高于同龄组男性。血脂代谢异常患病率随着年代的推移呈逐步上升趋势,总胆固醇从1991—1994年的24.5%到2001-2004年的38.1%(男性)和22.3%到38.5%(女性),且明显高于国内2000-2001年普查人群高脂血症的患病率。结论佛山地区血脂异常是ICVD的重要原因之一。  相似文献   
16.
一种新的正交参数选优法及其在非线性回归分析中的应用   总被引:2,自引:0,他引:2  
非线性回归分析是工程中经常采用的一种用来估计数学模型参数的方法,该方法能否顺利运用与参数初始值的选择有极大关系。本研究提出一种新的正交参数选优法——阻尼正交表法,它不仅可以保证非线性回归分析算法的顺利收敛,而且能够显著提高后者的收敛速度,进而极大改善非线性回归分析算法的应用性能。本研究的数值试验及心肌造影超声心动图定量分析应用实例表明,作为对传统正交参数选优法的一种改进,阻尼正交表法在科学与工程计算或信号与信息处理领域有着很好的应用前景。  相似文献   
17.
Changes in MAP2 and clathrin immunoreactivity were studied in gerbil hippocampus after transient cerebral ischemia. MAP2 immuno-reactivity decreased significantly by 1 h in the subiculum-CA1 and CA2 areas which correspond to reactive change, while no decrease was observed in CA1 until day 4. Before the initiation of delayed neuronal death, MAP2 immunoreactivity was not changed in CA1. On the other hand clathrin immunoreactivity increased in the pyramidal cell layer of CA1 by 3 h after ischemia and remained high for 2 days. Clathrin immunoreactivity in the pyramidal cell layer of CA1 diminished after delayed neuronal death. The transient change of clathrin was noted especially in CA1 in the period prior to delayed neuronal death. These results imply an abnormal change in clathrin turnover after ischemia, which may participate in the pathogenesis of delayed neuronal death.  相似文献   
18.
To clarify the role of serotonin in cerebral ischemia, we examined the effects of selective serotonin reuptake inhibitors, citalopram and clomipramine, on ischemic neuronal damage in the gerbil. Pretreatment with citalopram (40 mg/kg i.p.) and clomipramine (20 mg/kg i.p.) protected against neuronal destruction of hippocampal CA1 pyramidal cells following 5 min of forebrain ischemia. Furthermore, microdialysis assays showed that a striking increase in extracellular excitatory amino acid levels during ischemia was significantly inhibited by pretreatment with citalopram and clomipramine. However, citalopram (40 mg/kg i.p.) did not alter the extracellular amino acid concentrations in normal gerbils. Thus, serotonin reuptake inhibitors have a protective effect against ischemic neuronal damage. Furthermore, the present result suggests that the protective effect is mediated through prevention of the accumulation of extracellular excitatory amino acids during and after ischemia.  相似文献   
19.
A 66-year-old man with atrial fibrillation was referred soon after developing left lower limb and abdominal pain with rectal bleeding. An immediate flush aortogram showed embolic occlusion of the left distal superficial femoral artery and superior mesenteric artery (SMA), 3 cm from its ostium. Recombinant tissue plasminogen activitor (rtPA) 40 mg was selectively in stilled in the SMA in two boluses. Abdominal symptoms resolved within 48 h, and complete recanalization of the SMA was shown on angiography. Exploratory laparotomy after 72 h showed a normal small bowel and right colon, and was completed by femoropopliteal embolectomy. Six months later, the patient remained asymptomatic.  相似文献   
20.
We report a postpartum acute myocardial infarction that occurred during the first week after cesarean section delivery. We also calculated the rate of postpartum myocardial infarction as related to all women with myocardial infarctions seen in our hospital.(Am J Obstet Gynecol 1997;177:1553-5.)  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号