Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016

BackgroundPrevious studies have suggested that the possible relationship between serum uric acid (SUA) and testosterone. However, the results of previous studies are controversial and there is limited evidence examining the relationship between SUA and testosterone in a general US population of men. The objective of this study is to explore the correlation of SUA and testosterone among adult males from the US.MethodsData from the National Health and Nutrition Examination Survey 2011–2016 were used, including a total of 7,796 male participants aged 18 years or older and excluding those lacking serum testosterone and uric acid data. Clinical characteristics of the participants among different SUA groups and testosterone groups are compared. Univariate and multivariate linear regression analyses were applied to evaluate the association between SUA and testosterone.ResultsWe found an inverse association between SUA and testosterone after fully adjusted the potential confounding factors in general US adult males. In the multivariate linear regression analysis, we found that increasing age (estimate testosterone percent difference: −0.20% per year, P<0.01), uric acid (estimate testosterone percent difference: −4.40% per md/dL, P<0.01) and BMI (estimate testosterone percent difference: −2.86% per kg/m2, P<0.01) were associated with declining serum testosterone. This association remained significant in sensitivity analysis, while in the stratified analysis, above association was not significant in men with diabetes or aged 65 and over.ConclusionsSUA levels might be negatively associated with serum testosterone in adult males.     

超声诊断在乳腺癌前哨淋巴结检查中的应用进展

乳腺癌疾病是当前发病率比较高的一种疾病,发病的人群也趋于年轻化。前哨淋巴结是原发肿瘤发生淋巴结转移所必经的第一批淋巴结,其可以作为阻止肿瘤细胞从淋巴道扩散的屏障,临床意义受到人们重视,腋窝淋巴结状态是衡量乳腺癌患者恢复情况的重要指标。随着当前乳腺癌手术方式的多样化,在处理乳腺癌患者腋窝淋巴结的相关问题过程中也有了新的认识。超声是当前临床上比较常见的用于检查乳腺癌前哨淋巴结的方法,本文针对其实际应用和研究情况进行综述,旨在为临床实践提供参考。     

北京市健康体检机构放射卫生管理现状分析

目的 了解我市健康体检机构放射诊疗工作开展情况,规范健康体检机构放射诊疗行为。方法 依据《北京市卫生和计划生育监督所关于开展2019年健康体检机构放射诊疗专项监督检查工作的通知》的要求,采用现场检查、现场访谈方式开展调查工作。结果 本次健康体检机构的调查表明,北京市健康体检机构放射卫生管理工作总体良好,放射诊疗许可证持有率为100%。健康体检机构的放射诊疗工作以X射线摄影为主,215家健康体检机构共配置的放射诊疗设备822台,其中CT机138台,体检车20台,CT机占16.8%;健康体检机构的X射线摄影设备占总应用频次93%,CT机占总应用频次7.0%。215家健康体检机构全年放射诊疗应用频次约500万人次,被处罚机构占比较低,仅占2.8%,其中给予警告6户次,罚款2户次,发出处罚决定书6份,整改3户。结论 北京市健康体检机构放射卫生管理工作总体良好,在CT机合理应用、防护用品配置等方面仍存在一些问题,需进一步解决。     

矽肺患者血液流病变与血清免疫球蛋白关系的临床研究

为了探索矽肺患者免疫球蛋白的变化与血液流变学的关系,我们测定了本院门诊及住院的８３例不同期别矽肺病人的血清免疫球蛋白和血液流变学有关指标。结果显示：晚期（Ⅱ、Ⅲ期）和进展期矽肺患者的血液高粘滞状态不仅与红细胞比积及红细胞的粘弹特性有关,而且与血清免疫球蛋白、尤其是ＩｇＧ和ＩｇＡ的含量增加有关,而与纤维蛋白原未显示相关。     

妇幼保健机构二级评审中实现护理指标的探讨

妇幼保健机构等级评审细则对护理管理有明确的管理目标和量化指标。广州市妇幼保健院在二级妇幼保健机构等级评审工作中,护理管理确立以质量管理为核心,使护理管理工作制度化、质量管理标准化、质量控制数据化、技术操作规范化、病区设置规格化和日常工作程序化。按评审细则要求评价护理部在实施目标管理中对护理管理、院内感染管理和爱婴医院工作的管理能力和业务水平,注重考察护理人员的整体素质和操作技能,使护理工作趋向标准化、规范化和科学化管理。     

Traumatic injuries of the abdominal aorta.

Despite immediate operation, patients with abdominal aortic injuries and profound hypovolemic shock do not respond to the usual methods of resuscitation and die soon after celiotomy, prior to control and repair of the aortic injury. The rate of aortic hemorrhage exceeds the ability to restore blood volume. Shock becomes "irreversible." In such patients tamponade of the aortic injury may be effected by the use of an external counterpressure device such as a G-suit or MAST suit. These devices, used in conjunction with transthoracic aortic occlusion, may raise blood pressure sufficiently to perfuse the sritical coronary and cerebral circulation, allowing time to correct acidosis and locate, control, and repair the aortic injury. Early aggressive therapy should result in increased survival.     

Characteristics of tetrahydrocannabinol (THC)-produced discrimination in rats

Rats were trained in a T-shaped maze to discriminate the effects produced by i.p. injections of tetrahydrocannabinol (THC) and the no-drug state (state-dependency, StD). Several doses of both ⁸-THC (range: 0.75–5.0 mg/kg) and ⁹-THC (range: 0.75–10.0 mg/kg) were used in order to compare the number of sessions required by the animals until reaching criterion performance. An additional group of rats had to discriminate pentobarbital sodium (20.0 mg/kg) from the no-drug state.Results: THC discrimination was proportional to dose i.e., animals that had to differentiate high doses of THC from no drug acquired the T-maize task faster than animals trained with the lower doses of THC. Acquisition data further suggest that ⁸-THC is somewhat less potent than the ⁹-isomer. ⁹-THC (10.0 mg/kg) produces strong StD, as defined by Overton (1971), since both this group and the barbiturate group reached the criterion within the first 10 training sessions. Time and dose testings suggest that stimulus properties of drugs vary in a quantitative way and that the calculated ED₅₀ values are mainly determined by the training dose used. It was found that the higher the training dose used the higher was the corresponding ED₅₀ value. Hashish smoke can maintain drug responding among THC-trained rats. A lowered content of brain catecholamines and/or serotonin, induced by AMPT (150 mg/kg) and PCPA (310–350 mg/kg), did not lessen ⁹-THC (2.5 mg/kg) discrimination.Portions of the results were presented at the Fourth Scandinavian Meeting on Physiology and Behavior, Oslo May 22–24, 1975.     

2004年天津市农村14岁及以下居民健康体检结果分析

目的2004年对天津市14岁及以下年龄组农村居民进行身体健康检查，及时了解农村少年儿童的健康状况及影响因素，为改善农村居民健康提供科学依据。方法对天津市559103名14岁及以下农村人口进行身体健康检查，内容包括身高、体重等基本体征，内、外、五官科各项体征及3岁以下儿童的佝偻病、男童外生殖器、女童月经初潮年龄、7岁以下儿童的血红蛋白和血浆维生素A水平等项目进行健康检查。结果14岁及以下人群中，皮肤、耳、听力、心脏、肝脏、脾脏、肺、躯干四肢、精神发育正常、无内分泌及代谢性疾病、无染色体疾病的儿童在99．0％以上，0-6岁儿童的肥胖率为12．76％，7-14岁儿童的肥胖率为9．30％，5岁以下儿童生长迟缓率为12．79％，低体重率为5．17％，消瘦率为3．16％，3岁以下儿童佝偻病检出率为5．74％，7岁及以下儿童的贫血率为12．42％，维生素A缺乏率为2．23％。结论14岁及以下少年儿童的身体健康状况基本良好，存在的营养缺乏和超重肥胖问题应引起关注。     

针灸治疗持续性植物状态的研究进展

通过总结近10年来关于针灸治疗持续性植物状态(PVS)的资料,指出目前的现状和不足,在今后的研究上强调采取统一的诊断标准、较为客观的评定方法、基础研究和临床研究相结合,才能客观地证明和深入地探讨针灸对PVS的疗效.