芪贞降糖颗粒治疗糖尿病自主神经病变30例

目的观察芪贞降糖颗粒治疗糖尿病自主神经病变(diabetic autonomic neuropathy DAN)的临床疗效。方法将60例DAN患者随机分为对照组(30例)和治疗组(30例)。在糖尿病基础治疗的基础上,对照组口服甲钴胺,治疗组加用芪贞降糖颗粒口服。连续治疗3个月后,观察并比较两组DAN疗效、单个中医症状疗效及足汗腺神经受损风险的改善情况。结果治疗组的DAN疗效显著优于对照组(P0.05),总有效率显著高于对照组(P0.05);治疗组在改善倦怠乏力、口干咽燥、口渴喜饮、气短懒言、自汗盗汗方面显著优于对照组(P0.05);治疗组在降低足汗腺神经受损风险方面显著优于对照组(P0.01)。结论芪贞降糖颗粒可以明显改善DAN患者泌汗运动神经功能和DAN相关症状。     

贞芪扶正颗粒与顺铂和多西他赛化疗方案联用治疗宫颈癌的效果研究

目的 研究贞芪扶正颗粒与顺铂和多西他赛化疗方案联用治疗宫颈癌的效果。方法 选择2015年1月-2017年12月漯河市郾城区中医院收治的61例宫颈癌患者,随机分为两组。对照组采用顺铂联合多西他赛化疗方案,观察组在对照组基础上联用贞芪扶正颗粒治疗。1个治疗周期为21 d,共治疗5个周期。比较两组的T细胞亚群指标变化情况、生存质量评分和毒副作用发生情况。结果 观察组的有效率（76.67%）明显高于对照组（53.84%）,差异有统计学意义（P<0.05）。对照组治疗前后的自然杀伤细胞（NK）、CD4⁺、CD3⁺及CD8⁺相比无明显差异;观察组治疗后的T细胞亚群指标均明显优于治疗前和对照组,差异有统计学意义（P<0.05）。两组治疗后的生存质量卡氏（KPS）评分值均明显升高,同组治疗前后比较差异有统计学意义（P<0.05）;且观察组的KPS评分值明显高于对照组,差异有统计学意义（P<0.05）。观察组血小板降低、贫血、白细胞下降的发生率明显低于对照组,差异有统计学意义（P<0.05）,两组的胃肠道反应、肝功能损伤、口腔炎以及肾功能损伤发生率相比无明显差异。结论 在顺铂联合多西他赛化疗方案的基础上,联用贞芪扶正颗粒可以提高宫颈癌的治疗效果,增强患者的免疫功能,减少毒副作用的发生,提高生存质量。     

清宣止咳颗粒联合特布他林治疗小儿支气管哮喘的临床研究

目的探讨清宣止咳颗粒联合特布他林治疗小儿支气管哮喘的临床疗效。方法选取2017年5月—2018年5月在罗田县人民医院接受治疗的78例支气管哮喘患儿,根据用药方案分为对照组和治疗组,每组各39例。对照组通过雾化器给予硫酸特布他林雾化液,体质量小于20 kg患儿1 mL/次,体质量大于20 kg患儿2 mL/次,3次/d。治疗组在对照组治疗基础上口服清宣止咳颗粒,1～3岁,1/2袋/次,4～6岁,3/4袋/次,7～14岁,1袋/次,3次/d。两组均治疗2周。观察两组的临床疗效,比较两组症状改善时间、肺功能指标、炎症因子水平的变化情况。结果治疗后,对照组和治疗组的总有效率分别是82.05%、97.44%,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组患儿喘憋改善时间、咳嗽改善时间及肺部啰音改善时间均显著短于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患儿一秒用力呼气容积(FEV1)、用力肺活量(FVC)、最大呼气流量(PEF)均较治疗前明显升高,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组这些肺功能指标明显高于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组患儿血清白细胞介素-4(IL-4)、细胞间黏附分子-1(ICAM-1)、半胱氨酰白三烯(CysLTs)、基质金属蛋白酶-9(MMP-9)水平均较治疗前显著降低,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组这些炎症因子水平低于对照组,两组比较差异有统计学意义(P0.05)。结论清宣止咳颗粒联合特布他林治疗小儿支气管哮喘具有较好的临床疗效,可有效改善患儿临床症状,促进患儿肺功能改善,并可降低机体炎症反应,具有一定的临床推广应用价值。     

Chinese Herbal Medicine Shenqi Detoxification Granule Inhibits Fibrosis in Adenine Induced Chronic Renal Failure Rats

Background

Progressive fibrosis accompanies all chronic renal disease, connective tissue growth factor (CTGF,) and platelet-derived growth factor-B, (PDGF-B,) play important roles in extra-cellular matrix abnormal accumulation, while endothelin-1 (ET-1) nitric oxide (NO,) are related to endothelial dysfunction, which mediates the progression of renal fibrosis. Shenqi Detoxification Granule (SDG), a traditional Chinese herbal formula, has been used for treatment of chronic renal failure in clinic for many years.

Materials and Methods

In order to evaluate the efficacy, and explore the mechanism of SDG to inhibit the progression of renal fibrosis, study was carried out using the adenine-induced Wister rats as the CRF model, and losartan as postive control drug. Levels of serum creatinine [Scr], and blood urea nitrogen (BUN), albumin (ALB), 24hrs, urine protein (24hUP), triacylglycerol (TG), and cholesterol (CHO), together with ET-1, and NO were detected. Pathological changes of renal tissues were observed by HE, staining. In addition, CTGF and PDGF-B expression were analyzed by immuno-histo-chemistry.

Results

The results indicated that SDG can effectively reduce Scr, BUN, 24hUP, TG, and CHO levels, increase ALB levels, inhibit renal tissue damage in CRF rats, and the mechanism maybe reduce PDGF-B, CTGF expression and ET-1/NO.

Conclusion

Shenqi Detoxification Granule is a beneficial treatment for chronic renal failure.     

芹龙颗粒抗急性肝损伤的实验研究

目的观察芹龙颗粒（QL）对小鼠急性肝损伤的防治作用。方法将60只小鼠随机分为联苯双酯阳性药物组,正常动物组,CCl4模型对照组和QL大、中、小（10、5、2.5.gkg^-1）3个剂量组。药物组动物先分别灌胃给药3d,第4d,按体重腹腔注射0.5%浓度CCl4橄榄油溶液（10ml.kg^-1）,复制急性肝损伤动物模型。24h后取血测定血清中ALT,AST含量;并取肝脏,称重,10%甲醛固定,HE染色,于光镜下观察肝脏组织学变化。结果模型组小鼠肝功能明显异常,肝组织变性、坏死严重;QL组能明显改善CCl4中毒小鼠肝功能,其降酶率（ALT）以大、中、小剂量分别为54.3%、49.1%、41.2%。肝组织学改变较轻,体重减少较模型组轻。结论QL对CCl4致小鼠急性肝损伤具有明显的保护作用,其改善肝功能具有良好的量效关系。     

肾炎灵颗粒剂对慢性肾病血液流变学的影响

肾炎灵颗粒剂能改善慢性原发性肾小球疾病患者的血液流变学指标 ,说明有改善全身和肾组织微循环的作用 ,分析这可能是其临床疗效作用机理的一个组成部分。     

肠肛舒颗粒质量标准的研究

采用薄层色谱法对肠肛舒颗粒制剂中赤芍，黄芩，槐角，大黄进行定性鉴别；采用反相高效液相色谱法对制剂中赤芍所含芍药苷进行了含量测定。该方法简便，专属性及重现性好，平均回收率为１００．８２％，ＲＳＤ为１．９４％（ｎ＝６）。     

Effect of Weikangfu Granule (胃康复冲剂) on the Physiopathologic Figure of Precancerosis of Gastric Mucosa in Patients of Chronic Gastritis with Pi-Deficiency Syndrome

Objective: To study the physiopathologic basis of Weikangfu Granule ( 胃康复冲剂, WKFG)in treating precancerosis of gastric mucosa in patients of chronic gastritis with Pi-deficiency syndrome (CG-PDS). Methods: One hundred and fifteen patients of CG-PDS who suffered from intestinal metaplasia (IM)and atypical hyperplasia (ATHP) of gastric mucosa, were divided into two groups. The treated group (n =61 ) was treated by WKFG with its ingredients modified according to the syndrome type of patients. The constructural changes were detected by optical microscope, screening electronic microscope, transmission electronic microscope and histochemical staining; the nuclear and mitochondrial ultrastructure of gastric mucosa were analyzed with energy dispersion X-ray analyser and image analysis system. And the changes of cAMP,lipid peroxide (LPO), superoxide dismutase (SOD) before and after treatment in the treated group were measured and compared with those of the health control group consisting of 15 volunteers. Results: The symptomatic and pathological therapeutic effect in the treated group were significantly superior to those in the control group (P＜0.05). The contents of Zn, Cu, cAMP, SOD and 3H-TdR LCT in gastric mucosa of the treated group before treatment were all lower than those of the healthy control group, yet all these indexes markedly increased after treatment, while serum LPO level, which increased before treatment was lowered after treatment. All the changes showed statistical significance (P＜0.05 or P＜0.01). Conclusion: WKFG can reverse IM and ATHP in patients of CG-PDS, and the effect may be realized by way of increasing the level of Zn, Cu, cAMP and SOD in gastric mucosa, promoting cell differentiation, enhancing cellular immunity and reducing oxygen free radicals and lipid peroxidation.     

治糖保肾冲剂治疗早期糖尿病肾病疗效观察

目的 :观察治糖保肾冲剂治疗早期糖尿病肾病的疗效。方法 :采用随机、对照法研究治糖保肾冲剂的临床疗效。结果 :苯那普利组可降低患者尿白蛋白排泄率 ,治糖保肾冲剂加苯那普利组在中医症状改善、降低血糖、减少尿白蛋白排泄率方面均优于苯那普利组 (P <0 .0 5 ,0 .0 1)。结论 :治糖保肾冲剂对糖尿病肾病有明显的疗效。     

青梅感冒冲剂中的岗梅和甘草的薄层色谱鉴别

目的：研究青梅感冒冲剂中岗梅、甘草的薄层色谱鉴剐方法。方法：分别取甘草药材、岗梅药材、青梅感冒冲剂及阴性制剂的乙酸乙酯提取液，在硅胶板上前者以ψ(苯：乙酸乙酯：水)：5：2：0．1展开，后者以ψ(甲苯：乙酸乙酯：水)=5：2：0．1展开，在紫外灯(365 nm下)检视。结果：在两者供试品色谱中与各自对照药材色谱相应位置上，均有相同的特征斑点，阴性制剂色谱图中无此斑点。结论：该法专属性强，为该制剂增加质量控制指标提供了实验依据。