Value of lipid layer thickness and blinking pattern in approaching patients with dry eye symptoms

ObjectiveTo analyze the relationship between dry eye symptoms and modern dry eye tests, including the Schirmer I test, lipid layer thickness (LLT), and blinking pattern by LipiView interferometer.DesignCross-sectional study.Participants115 dry eye outpatients.MethodsDry eye symptoms were quantified by questionnaire scores, such as Ocular Surface Disease Index (OSDI) and Standard Patient Evaluation of Eye Dryness (SPEED). LLT, complete, and incomplete blinking rate were recorded by the LipiView interferometer.Results115 patients (229 eyes, mean age = 60.5 ± 13.6 years) were enrolled in this study. The mean value of the SPEED and OSDI scores was 9.5 and 10.2, respectively. A total of 44.3% of all subjects had severe dry eye syndrome (SPEED, OSDI ≥ 10). LLT (mean = 71.2 nm) was inversely correlated with both the SPEED and OSDI (p = 0.003 and 0.004, respectively). The incomplete-to-complete ratio of blinking rate (i/c ratio) was correlated with both the SPEED and OSDI (p = 0.0048 and 0.0234, respectively). Patients with LLT less than 69 nm were more likely to have severe dry eye syndrome. There was no significant relationship between the Schirmer I test and the SPEED or OSDI. However, LLT was inversely related to the Schirmer I test (linear regression, p = 0.0002, r = ?0.1857).ConclusionsLLT and the i/c ratio were significantly correlated to dry eye symptoms. Eyes with thinner LLT are more likely to have better aqueous tear production. The role of the reciprocal influence between each tear component in the maintenance of tear function warrants further investigation.     

Thrombospondin 1 Is Increased in the Aorta and Plasma of Patients With Acute Aortic Dissection

Background

Previous studies have shown that thrombospondin 1 (TSP-1) is involved in cardiovascular diseases, such as atherosclerosis and abdominal aortic aneurysm. However, TSP-1 expression levels in human aortic dissection (AD) remain unknown.

决明子茶提取物中还原糖的含量测定

目的:对决明子茶进行有效成分的提取,并测定其提取物中还原糖的含量。方法:分别用蒸馏水,PH8的碱水5,%的稀醇和醇碱,进行回流提取,其提取液用菲林氏容量法测定还原糖的含量。结果:样品试液滴定量的平均体积为14.9,还原糖的含量为0.09359%。结论:此实验影响测定结果的主要操作因素是反应液的碱度,热源强度,煮沸时间和滴定速度,一般煮沸时间短消耗糖量多,反之,消耗糖量少;滴定速度快,消耗糖量多,反之,消耗糖量少。另外溶液碱度越高,二价铜还原越快,因此,必须严格控制反应的体积,使反应体系碱度一致。     

基于知识考古学的《临证指南医案》“肝阳”概念形成分析

《临证指南医案》“肝阳”概念的对象是肝及肝病本身的特征。肝阳与肝的关系是肝生肝阳,肝阳与肝阴之间是体用关系。肝阳概念的对象及肝阳与其他概念间的关系源于理学中的“理一分殊”“理学世界图示”和“体用一源”。理一分殊决定了肝阳的对象是肝及肝病本身的特征;理学世界图式决定了肝阳与肝的关系是肝生肝阳;体用一源确定了肝阳与肝阴之间是体用关系。《临证指南医案》的肝阳概念主要来源于理学。厘清《临证指南医案》肝阳的发生学基础,解决其理论来源问题,无论是对古代文献的研究、肝脏象理论、中医脏象理论的研究,还是对现代肝脏象理论、中医脏象理论和中医理论的构建都有积极的意义。     

《医林大观书目》述论

学术界普遍认为：清朝乾隆年间改师立编纂的《医林大观书目》已经散佚。实际上该书一直以稿本存世,2000年被影印出版。作为现存第二早的中医专科目录,《医林大观书目》虽然编次草草,但以其前面分时后面分类的独特著录方式、合理清晰的类目设置及专门设置“经典诸家注”类目等优点在中医目录史上占有一席之地。特别是改师立作为《医宗金鉴》的誊录官,所撰的《医林大观书目》蕴含了《医宗金鉴》的大量信息,对研究《医宗金鉴》具有重要意义。     

克林霉素结合利巴韦林治疗小儿疱疹性咽峡炎及口腔炎60例疗效分析

目的：探讨克林霉素结合利巴韦林治疗小儿疱疹性咽峡炎及口腔炎的临床效果及安全性。方法对该院于2013年1月-2013年9月收治小儿口腔炎和小儿疱疹性咽峡炎进行研究,随收入时间及床号分为观察组和对照组各30例,对照组采用利巴韦林治疗,观察组在对照组基础上加用克林霉素治疗,比较两组患儿治疗效果。结果观察组总有效率为96.67%,明显高于对照组76.67%,差异具有统计学意义（P<0.05）。观察组退热时间、疱疹或溃疡面消退时间、饮食恢复时间及住院时间明显短于对照组（P<0.05）。观察组和对照组药物不良反应发生率比较差异无统计学意义（P>0.05）。结论克林霉素结合利巴韦林雾化、静脉滴注治疗小儿疱疹性咽峡炎及口腔炎,可缩短退热时间、住院时间等,疗效优越,且不良反应少,值得临床推广。     

Validity of Cyriax’s Functional Examination for Diagnosing Shoulder Pain: A Diagnostic Accuracy Study

ObjectiveThe purpose of this study was to compare the diagnostic accuracy of lesion localization between Cyriax’s functional examination and ultrasonography in participants with and without shoulder pain.MethodsA total of 206 adults aged 20 years and older with or without shoulder pain were included. All participants received Cyriax’s functional examination by the first blinded physiatrist. Within a week, ultrasonography was performed by another blinded specialist. The diagnoses made by both methods, respectively, were compared finally. Sensitivity, specificity, and positive and negative predictive values were evaluated for the diagnosis of shoulder lesions between Cyriax’s functional examination and ultrasonography.ResultsThere was no significant difference between the 2 groups regarding age, sex, and body mass index. Moderate to high sensitivity (74.1%, 76.5%, and 66.7%) and high specificity (93.0%, 99.5%, and 99.0%) were in supraspinatus, subscapularis, and infraspinatus lesions, respectively. For the subacromial-subdeltoid bursitis, high sensitivity (90.4%) and moderate to high specificity (70.3%) was found. In contrast, low sensitivity (15.0%) and high specificity (100.0%) were found in the biceps lesions.ConclusionIn this study, we found that Cyriax’s functional examination had high sensitivity in detecting subacromial-subdeltoid bursitis and high specificity in rotator cuff lesion.     

Integrating hinge axis approximation and the virtual facial simulation of prosthetic outcomes for treatment with CAD-CAM immediate dentures: A clinical report of a patient with microstomia

This clinical report describes a digital workflow using extraoral digital photographs and volumetric datasets from cone beam computed tomography (CBCT) imaging to create a 3-dimensional (3D), virtual patient with photorealistic appearance. In a patient with microstomia, hinge axis approximation, diagnostic casts simulating postextraction alveolar ridge profile, and facial simulation of prosthetic treatment outcome were completed in a 3D, virtual environment. The approach facilitated the diagnosis, communication, and patient acceptance of the treatment of maxillary and mandibular computer-aided design and computer-aided manufacturing (CAD-CAM) of immediate dentures at increased occlusal vertical dimension.     

Polyetherketoneketone (PEKK), a framework material for complete fixed and removable dental prostheses: A clinical report

This clinical report demonstrates the use of polyetherketoneketone (PEKK) as a framework material with individually luted heat-pressed lithium disilicate glass-ceramic crowns for an implant-supported complete fixed dental prosthesis (ICFDP) and a conventional complete removable dental prosthesis (CRDP). This prosthesis design provides a non–computer-aided design and computer-aided manufacturing (CAD-CAM) option for the fabrication of ICFDPs and CRDPs with individualized ceramic crowns for optimal esthetics. The performance of PEKK as a framework material needs to be assessed in clinical trials.