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991.
目的:探究不同时机注射人绒毛膜促性腺激素(hCG)行短效长方案卵胞质内单精子注射(ICSI)助孕术患者的临床结局影响。方法:回顾性分析行ICSI助孕术的200例患者,按传统标准的hCG注射日时间(有3个卵泡平均直径≥17 mm)比较推迟2 d(+2组,n=167)、推迟3 d(+3组,n=31)和推迟4 d(+4组,n=2)ICSI助孕过程中的临床参数及妊娠结局。结果:+3组与+2d组比较,平均直径≥20 mm的卵泡数有上升趋势(6.1±2.4 vs 5.4±2.3);hCG注射日最大卵泡的平均直径达到25.0±2.6 mm,两者有统计学差异(P0.05);≥20 mm/≥14 mm比值组间差异更大(0.52±0.16 vs 0.46±0.13,P0.05),P×1 000/E2有降低趋势(0.23±0.12 vs 0.42±1.44),E2/≥14 mm的卵泡数比值有上升趋势(276.73±93.55 vs 246.23±77.03)。卵子回收率、MII卵率、受精率、优质胚胎率、周期取消率、着床率、临床妊娠率、自然流产率、宫外孕率及OHSS发生率均无统计学差异(P0.05)。结论:对短效长方案患者适度推迟注射hCG时间是值得推行的。 相似文献
992.
目的评估常规IVF低受精率周期行补救ICSI（rescue intracytoplasmic sperm injection,R-ICSI）的临床结局。方法回顾分析了本中心2009年1月至2012年6月,104例常规IVF低受精率周期行R-ICSI的结果。结果 104例周期中,常规IVF的2PN数只有1个是85例,最后2PN没有形成可利用胚胎是18个周期;常规IVF的2PN数大于等于2个有19例,最后2PN没有形成可利用胚胎是1个周期。结论 2PN数是1个常规IVF低受精率周期,为了避免移植周期取消,可以行R-ICSI。2PN数大于等于2个的周期,根据未受精MⅡ卵数决定是否行R-ICSI。 相似文献
993.
目的研究男方染色体多态性对精子质量及体外受精-胚胎移植(IVF-ET)结局的影响。方法回顾性比较IVF/卵胞质内单精子显微注射(ICSI)-ET助孕治疗的男方染色体多态(n=131)和正常对照夫妇(n=160)的妊娠结局,观察男方的精子质量和受精情况、临床妊娠率、早期流产率。结果男方染色体多态组中严重少/弱精子症(19.85%)比例显著高于染色体正常组(5.00%,P0.001),Yqh+在严重少/弱精子症(38.46%)中的比例最高;Yqh-也高达15.38%,1qh+在严重少/弱精子症组是最常见的常染色体多态类型(19.23%);染色体多态组的女方年龄、体质量指数(BMI)、基础性激素水平均无统计学差异(P0.05),男方前向精子率(PR%)、精子正常率以及获卵数、移植胚胎数均无统计学差异(P0.05)。染色体多态组行IVF-ET助孕治疗后,其着床率(17.42%)、临床妊娠率(28.17%)均显著低于正常对照组(32.26%,59.38%)(P0.05);并且早期流产率(11.11%)高于对照组(2.04%),但差异无统计学意义(P0.05)。染色体多态组行ICSI-ET助孕治疗后与正常对照组妊娠结局无统计学差异(P0.05),优质胚胎率(75.24%±23.68%)还高于正常对照组(49.97%±29.31%)(P0.05)。行ICSI-ET助孕的男方染色体多态患者其着床率(34.78%)以及临床妊娠率(52.00%)显著高于行IVF-ET助孕的男方染色体多态患者(17.42%,28.17%)(P0.05)。结论男性染色体多态性患者中严重少/弱精子的比例增加,男性染色体多态不利于IVF妊娠结局,对ICSI影响较小。 相似文献
994.
AimThe aim of this study was to analyse the correlation between various reactions displayed by the oolemma to the penetrating pipette during intracytoplasmic sperm injection (ICSI) and embryo developmental competence after ICSI procedure.Materials and methodsThe injected metaphase II (MII) oocytes which showed different responses to the injection pipette were classified into three groups (100 oocytes each) according to types of oolemma responses. Group 1: no resistance breakage, Group 2: (curve shape) mild resistance, Group 3: (funnel shape) good resistance.ResultsThe results showed that classification based on oolemma behavior during ICSI procedure (Groups 1–3) indicates a significant correlation with fertilization rate (2PN) (55%, 87% and 72%, respectively P<0.01) and cleavage rate (75%, 96% and 79%, respectively P<0.01) and embryo quality (4–8 cells Grade 1 embryo) (50%, 90% and 70%, respectively P<0.001).ConclusionThe current study provides evidence that preselection at a very early stage based on oolemma behavior may be helpful to identify a subgroup of preimplantation embryos with good prognostic to form blastocyst and consequently to implant and to give pregnancy. 相似文献
995.
996.
Hanan Alanazi Nayla Bushaqer Hisham Ayyoub Nawal Dayoub Samar Hassan 《Middle East Fertility Society Journal》2018,23(3):246-250
Objective
to study AMH level effect on IVF/ICSI cycle outcome in expected poor responders undergoing ART.Design
retrospective cohort study.Setting
IVF unit at king Abdulaziz medical city, Riyadh, KSA.Materials and methods
258 patients expected to be poor responders according to Bolonga criteria (aged >37or previous poor ovarian response or patients with decreased ovarian reserve) had their serum AMH level obtained and underwent IVF/ICSI cycles between April 2013 to April 2015.Outcome
pregnancy and cancellation rates.Results
patients were divided into three groups according to their AMH level, 60 Patients with AMH level ≤2.8, 98 patients with AMH level 2.9-14.9, and 100 patients with AMH level >15?pmol/l. Patients with lowest AMH had lowest AFC, highest FSH, and lowest number of previous delivery. Lowest AMH patients had lowest number of oocytes collected (p?<?.0001), lowest pregnancy rate (p?=?.001), and highest cancellation rate (p?<?.001).The receiver operating characteristic (ROC) curve analysis was used to establish the cut-off value for serum AMH level in predicting cancellation of ART cycle. It revealed a cutoff point of 2.8?pmol/L with sensitivity of 85% and specificity of 45% (DeLong SE?=?0.04: CI 0.58-0.75). ROC of AMH level and pregnancy prediction showed a cut off point of 16.2?pmol/L with sensitivity 54% and specificity of 66% (DeLong SE?=?0.04: CI 0.53-0.69).Conclusion
Low AMH level in expected poor responders in ART cycles had lower pregnancy rate and higher cancellation rate. 相似文献997.
Mohamed Anwar Elnory Ashraf Nassif Mahmoud Elmantwe 《Middle East Fertility Society Journal》2018,23(4):357-362
Aim
To compare effectiveness of calcium infusion (CI) versus oral cabergoline (OC) in lowering the incidence and severity of ovarian hyperstimulation syndrome (OHSS) in high risk women undergoing in vitro-fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles.Patients and methods
This trial was conducted at Benha University Hospital and Hawaa specialized infertility center, including 230 women undergoing ICSI, 115 women received intravenous Calcium gluconate starting at ovum pick up (OPU) day and 115 women received OC 0.5?mg starting at the day of OPU outcomes were the overall incidence of OHSS as well as its type and severity, in addition to others pregnancy outcomes data.Results
The occurrence of overall OHSS was significantly lower in calcium infusion group (CIG) than in oral cabergoline group (OCG) [16/115 (13.9%) in CIG versus 32/115 (27.8%)] in OCG with difference in proportion percentage point (Δ pp)?=??13.9% , at 95%CI of ?3.38% to ?24.10% (P?=?0.009) and absolute risk reduction (ARR) in overall OHSS incidence?=?13.9% at 95%CI of 3.38–24.10 and relative risk (RR)?=?0.5 at 95% CI of 0.29–0.85 (p?=?0.012) and relative risk reduction (RRR)?=?50% and number need to treatment (NNT) (Benefit)?=?7.18 at 95% CI of 4.12 (Benefit) to 28.05 (Benefit)]. Also the incidence of Moderate OHSS was significantly lower in CIG than OCG [2/115 (1.7 %) vs 10/115 (8.6%), p?=?0.01] as well as RR of severe OHSS with CI to OC?=?0.25 at 95%CI of 0.02–2.20 and RRR of severe OHSS with CI to OC was 75% as it occurred in 4 cases (3.4%) in OCG versus one case (0.8%) in CIG, where this reduction is of great clinical significant despite it does not reach statistical significance (P?=?0.17), at NNT (Benefit)?=?38.33 at 95% CI of 87.292 (Harm) to ∞ to 15.716 (Benefit) .Other pregnancy outcomes didn't show any statistically significant differences.Conclusion
Calcium infusion is more effective than oral cabergoline intake from OPU day in the reduction of OHSS overall incidence as well as its severity with comparable pregnancy outcomes.Trial registration: https://clinicaltrials.gov/ct2/show/NCT03473613. 相似文献998.
Aim
To evaluate the efficacy endometrial fluid aspiration at the time of egg collection.Methods
A prospective non-randomized pilot study of twelve infertile women who had ART (IVF-ICSI) at a University affiliated assisted conception unit. All women had persistent endometrial cavity fluid (ECF) in a controlled ovarian stimulation on the day of ovulation triggering.Results
Following the discovery of ECF on the day of ovulation triggering, all women were counselled for the possible management options. None of these women hadopted for the alternatives of freeze all or aspiration of ECF just prior to ET. In ten women ECF was aspirated at the time of egg collection. Five out the ten women in whom ECF aspiration was performed became pregnant (50%). Spontaneous resolution of ECF occurred in the remaining two patients; both became pregnant.Conclusions
Aspiration of ECF at the time of egg collection is another new option for women with ECF. It obviated the need to freeze all or aspirate of ECF at the time of ET. It was associated with a good success andcan be a new convenient option in couples residing in low income countries. More studies are needed to establish the best management of ECF. 相似文献999.
Nayla Bushaqer Wadha Mohawash Fatima Alrakaf Meshael Algaffli Haya Rawah Nawal Dayoub Hisham Ayoub Nouf Alasmari 《Middle East Fertility Society Journal》2018,23(2):137-142
Objective
to evaluate the impact of serum progesterone level on the clinical outcome across agonist & antagonist protocols.Design
retrospective cohort study.Setting
IVF unit at Prince Sultan Military Medical City, Riyadh, KSA.Material & Methods
A total of 943 cycles were included in the analysis, 605 long agonist protocol cycles, 227 antagonist protocol cycles & 101 short agonist protocol cycles reaching the stage of embryo transfer between November 2012 and March 2015.Main outcome
clinical pregnancy and miscarriage rates.Results
Number of retrieved, mature and fertilized oocytes, plus transferred embryos were lowest in the short protocol. Clinical pregnancy rate was the lowest in the short protocol and miscarriage rate was similar in all protocols. Setting progesterone cut off level of >1.5 nmol/L in the agonist cycles, high progesterone groups did not show difference in clinical pregnancy or miscarriage rates. In the short protocol, the group with high progesterone level had higher number of frozen embryos. In long protocol, high progesterone level group showed higher number of fertilized oocytes. A level of >2 nmol/L was set in the antagonist protocol. High progesterone group had lower clinical pregnancy rate and similar miscarriage rate, despite having higher number of fertilized oocytes and better quality of embryos.Conclusion
high progesterone level did not affect clinical pregnancy or miscarriage rates in all protocols except in the antagonist protocol where it affected the clinical pregnancy rate adversely. 相似文献1000.