全文获取类型
收费全文 | 1222篇 |
免费 | 115篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 1篇 |
妇产科学 | 4篇 |
基础医学 | 39篇 |
口腔科学 | 5篇 |
临床医学 | 15篇 |
内科学 | 54篇 |
皮肤病学 | 1篇 |
神经病学 | 14篇 |
特种医学 | 7篇 |
外科学 | 16篇 |
综合类 | 167篇 |
预防医学 | 71篇 |
眼科学 | 1篇 |
药学 | 522篇 |
中国医学 | 415篇 |
肿瘤学 | 36篇 |
出版年
2024年 | 2篇 |
2023年 | 13篇 |
2022年 | 21篇 |
2021年 | 34篇 |
2020年 | 35篇 |
2019年 | 25篇 |
2018年 | 38篇 |
2017年 | 28篇 |
2016年 | 42篇 |
2015年 | 38篇 |
2014年 | 94篇 |
2013年 | 105篇 |
2012年 | 96篇 |
2011年 | 126篇 |
2010年 | 97篇 |
2009年 | 90篇 |
2008年 | 87篇 |
2007年 | 104篇 |
2006年 | 49篇 |
2005年 | 55篇 |
2004年 | 38篇 |
2003年 | 19篇 |
2002年 | 19篇 |
2001年 | 11篇 |
2000年 | 8篇 |
1999年 | 18篇 |
1998年 | 8篇 |
1997年 | 5篇 |
1996年 | 12篇 |
1995年 | 5篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 7篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1981年 | 2篇 |
1979年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1973年 | 1篇 |
1971年 | 2篇 |
排序方式: 共有1368条查询结果,搜索用时 330 毫秒
51.
栀子的化学成分 总被引:8,自引:0,他引:8
目的:对栀子(Gardenia jasminoides Ellis)的化学成分进行研究。方法:采用不同柱色谱技术进行分离,通过波谱分析确定化合物结构。结果:分离鉴定了14个化合物,其中6个为黄酮类化合物,分别为croymbosin(1)、槲皮素(2)、芦丁(3)、umuhengerin(4)、nicotiflorin(5)、异槲皮苷(6);8个为有机酸类,分别为绿原酸(7)、3,4-二咖啡酰奎宁酸(8)、3-咖啡酰-4-芥子酰奎宁酸(9)、3-咖啡酰-4-芥子酰奎宁酸甲酯(10)、3-咖啡酰-5-芥子酰奎宁酸甲酯(11)、3,4-二咖啡酰-5-(3-羟-3-甲基)戊二酰奎宁酸(12)、3,5-二咖啡酰-4-(3-羟-3-甲基)戊二酰奎宁酸(13)、原儿茶酸(14)。结论:化合物2~6和14为首次从该植物中分离得到,其中化合物2,3,5,6和14系首次从该属植物中分离得到。 相似文献
52.
正交实验优选地黄叶中梓醇的提取工艺 总被引:1,自引:0,他引:1
目的对干地黄叶中梓醇的提取方法进行优选,确定最佳提取工艺。方法采用正交实验表L8(2)^7安排实验。结果提取方法对梓醇提取率影响最大。结论确定地黄叶中梓醇的最佳提取工艺,即加水煎煮提取,提取次数为2次,1h/次。 相似文献
53.
54.
目的:建立山楂叶提取物中熊果酸的含量测定方法。方法:高效液相色谱法,C18柱,以甲醇-水-磷酸(90∶10∶0.03)为流动相,流速为0.5mL·min-1,检测波长为220nm。结果:熊果酸在(0.982~9.82)μg·mL-1范围内与峰面积线性关系良好,相关系数为0.9998,平均回收率为98.16%,RSD为0.58%(n=6)。结论:方法简便,准确,重复性好,适用于山楂叶提取物的质量控制。 相似文献
55.
56.
Summary
Background. It is widely believed that antioxidant micronutrients obtained from fruit and vegetables afford significant protection against
cancer and heart disease, as well as ageing. Flavonoids are potential antioxidants found in food such as onions; information
on their effectiveness in vivo is so far lacking. Aims. To determine uptake as well as in vivo antioxidant effects of flavonoids from foods. Methods. Six healthy non-obese normocholesterolaemic female volunteers in the age range 20–44 years participated in a randomised two-phase
crossover supplementation trial to compare the antioxidant effects associated with (a) a meal of fried onions and (b) a meal
of fried onions and fresh cherry tomatoes. Plasma flavonoids, lymphocyte DNA damage, plasma ascorbic acid, tocopherols and
carotenoids, urinary malondialdehyde and 8-hydroxy-2’-deoxyguanosine were determined to assess flavonoid absorption and antioxidant
efficacy. Results. Flavonoid glucosides (quercetin-3-glucoside and isorhamnetin-4-glucoside) were significantly elevated in plasma following
ingestion of the onion meal and the increases were associated with an increased resistance of lymphocyte DNA to DNA strand
breakage. A significant decrease in the level of urinary 8-hydroxy-2’-deoxyguanosine was evident at 4 h following ingestion
of the onion meal. After the combined tomato and onion meal, only quercetin was detected in plasma. Endogenous base oxidation
was decreased but resistance to strand breakage was unchanged. There was no significant change in the excretion of urinary
malondialdehyde following either meal. Conclusion. Both meals – onions, and onions together with tomatoes – led to transient decreases in biomarkers of oxidative stress, although
the particular biomarkers affected differ. It is possible that the differences in patterns of response reflect the different
uptakes of flavonoids but the underlying mechanism is not understood.
Received: 1 April 2000, Accepted: 1 August 2000 相似文献
57.
Butterweck V Nahrstedt A Evans J Hufeisen S Rauser L Savage J Popadak B Ernsberger P Roth BL 《Psychopharmacology》2002,162(2):193-202
RATIONALE: Hypericum perforatum L. (St. John's wort; SJW) is one of the leading psychotherapeutic phytomedicines and great effort has been devoted to clarifying its mechanism of action. OBJECTIVE: We have undertaken a comprehensive analysis of several pure compounds isolated from the crude extract to gain further insight into the molecular actions of various substituents of SJW. METHODS: We characterized the in vitro pharmacology of the naphthodianthrones hypericin and pseudohypericin, the phloroglucinol derivative hyperforin, and several flavonoids at 42 biogenic amine receptors and transporters using the resources of the National Institute of Mental Health Psychoactive Drug Screening Program. RESULTS: The biflavonoid amentoflavone significantly inhibited binding at serotonin (5-HT(1D), 5-HT(2C)), D(3)-dopamine, delta-opiate, and benzodiazepine receptors. The naphthodianthrone hypericin had significant activity at D(3)- and D(4)-dopamine receptors and beta-adrenergic receptors. With the exception of the D(1)-dopamine receptor, the phloroglucinol derivative hyperforin was less active than other SJW constituents tested on all screened receptors. CONCLUSION: Our present in vitro data clearly show that several pure substances in SJW are potential CNS psychoactive agents and may contribute to the antidepressant efficacy of the plant in a complex manner. Our data also reveal novel and heretofore unexpected interactions of pure compounds in SJW at a number of GPCRs, transporters, and ion channels. We hypothesize that additive or synergistic actions of different single compounds may be responsible for the antidepressant efficacy of SJW. These results and this general approach may impact our understanding of phytomedicines in general and H. perforatum specifically. 相似文献
58.
Paola Montoro Carlo I.G. Tuberoso Sonia Piacente Angela Perrone Vincenzo De Feo Paolo Cabras Cosimo Pizza 《Journal of pharmaceutical and biomedical analysis》2006,41(5):1614
Flavonoids and anthocyanins in berry extracts from Myrtus communis, prepared by following a typical Sardinia myrtle liqueur recipe, were identified by HPLC coupled with Electrospray Mass Spectrometry and quantified by HPLC coupled with Ultraviolet/Visible Detection in order to evaluate the stability of the extracts during 1 year of storage. Antioxidant activity was measured by using TEAC assay, and the free-radical scavenging activity was monitored during time of the stability evaluation.Anthocyanins have found to be the most instable compounds, but a considerable instability was observed also for flavonoids, suggesting the use of extracts not over 3 months from their preparation. The myrtle extract showed interesting free-adical scavenging activity. Antioxidant activity was preserved in 3 months. 相似文献
59.
目的:研究鸢尾科鸢尾属植物马蔺(Iris lactea Pall.var.chinensis(Fisch.)koidz.)地下部分的化学成分.方法:采用70%乙醇提取,硅胶柱层析分离及重结晶等方法分离其化学成分,通过波谱及化学方法进行结构鉴定.结果:分离并鉴定了10个化合物,分别为:5-羟基-7-甲氧基黄酮(tectochrysin,Ⅰ)、5,2'-二羟基-6,7-亚甲二氧基二氢黄酮(5,2'-dihydroxy-6,7-methylenedioxyflavanone,Ⅱ)、5,7-二羟基-6,2'-二甲氧基异黄酮(5,7-dihydroxy-6,2'-dimethoxyisoflavone,Ⅲ)、4',5-二羟基-6,7-二甲氧基异黄酮(4',5-dihydroxy-6,7-dimethoxyisoflavone,Ⅳ)、4',5,7-三羟基-6-甲氧基异黄酮(tectorigenin)(4',5,7-trihydroxy-6-methoxyisoflavone,Ⅴ)、5,3'-二羟基2'-甲氧基-6,7-亚甲二氧基异黄酮(5,3'-dihydroxy-2'-methoxy-6,7-methylenedioxyisoflavone,Ⅵ)、5,2'-二羟基-6,7-亚甲二氧基异黄酮(5,2'-dihydroxy-6,7-methylenedioxyisoflavone,Ⅶ)、irisoid D(Ⅷ)、irisoid A(Ⅸ)和十七烷酸(heptadecanoic acid,X).结论:这些化合物均为在该植物中首次分得,其中化合物Ⅵ为本属植物中首次发现. 相似文献
60.
Joanne M. Holden Seema A. Bhagwat David B. Haytowitz Susan E. Gebhardt Johanna T. Dwyer Julia Peterson Gary R. Beecher Alison L. Eldridge Douglas Balentine 《Journal of food composition and analysis》2005,18(8):829-844
The USDA Special Interest Database for flavonoid content of selected foods contains 26 most abundant compounds within 5 predominant subclasses of flavonoids–flavonols, flavones, flavanones, flavan-3-ols, and anthocyanidins. All the data were evaluated for 5 quality evaluation categories (sampling plan, sample handling, analytical method, analytical quality control and number of samples), using the data quality evaluation system developed by the USDA scientists. Confidence Codes (A–through D) were then assigned to every value. The database contains acceptable values for 225 selected foods. Only 97 sources out of approximately 475 collected included acceptable analytical data. The overall quality of data was good with 64% of the observations receiving A or B confidence codes; the flavan-3-ols subclass received better ratings than other subclasses. While this is the first comprehensive database for flavonoids in foods, the majority of data came from Europe and countries other than the US. Due to the observed variability in the values it will be important to have data for US foods. The evaluation of data quality helps set priorities and further identifies the foods to be analyzed as well as areas to improve data quality. Furthermore, release of data quality confidence codes with data provides necessary information to investigators to assess the impact of flavonoid intake on risk of various chronic diseases. 相似文献