The Role of Endoplasmic Reticulum Stress-related Apoptosis in Vascular Endothelium Pathogenesis

正Vascular endothelium refers to a single layer of endothelial cells that line the inner surface of blood vessels,serving as barriers and transducers between the circulating blood in the lumen and the rest of the vessel wall.Endothelial cells play essential roles in many aspects of vascular biology,such as barrier functions,thrombosis/fibrinolysis,inflammation,angiogenesis,vasoconstriction and vasodilation,and     

Transarterial chemoembolization plus iodine-125 implantation for hepatocellular carcinoma: a systematic review and meta-analysis

Background

Hepatocellular carcinoma (HCC) is the most common malignancy in liver. Transarterial chemoembolization (TACE) is recommended as an effective treatment in advanced HCC patients. Recent studies showed iodine-125 seed (a low-energy radionuclide) can provide long-term local control and increase survival for HCC patients. The aim of the study was to evaluate the outcome of TACE plus iodine-125 seed in comparison with TACE alone for HCC.

郭勇教授治疗肿瘤常用药组拾萃

中药药组属“药对”范畴,是指通过临床应用被证明确有实效的几味药物的配伍方式。郭勇教授从事中西医肿瘤内科工作30余载,在中西医配合治疗肿瘤方面积累了丰富的经验,遣方用药已形成一定的个人特色,善用药组。笔者通过拾取郭老师临床常用的9个药组, 分析老师的用药规律及思路。     

Association of metabolic syndrome with atherogenic index of plasma in an urban Chinese population: A 15-year prospective study

Background and aimsThe metabolic syndrome(Mets) is a multiplex risk factor for atheroselerotie cardiovascular disease. The aims of the study were to assess the association of the Mets with atherogenic index of plasma(AIP) and other atherogenic parameters in an urban Chinese population.Methods and resultsThe data were collected in 1992 and then again in 2007 from the same group of 582 individuals(359 men and 223 women) without Mets in 1992. During 15 years’ follow-up, AIP was the lipid parameter that was most strongly associated with Mets, with an unadjusted odds ratio of 5.66 (95% CI:1.76–18.23, P = 0.004) in the univariate logistic regression analysis. Multivariate logistic regression analyses also revealed that AIP was an independent risk factor for Mets. AIP significantly predicted Mets in men, with an unadjusted odds ratio of 30.73 (95% CI: 5.62, 168.12 P = 0.012) in a univariate model. Associations remained significant after adjustment for smoking, drinking, physical exercise and components of Mets. The incidences of Mets adjusted for age according to the quartiles of AIP showed a statistical linear trend in men(P for trend = 0.007) rather than in women(P for trend = 0.529).ConclusionsAIP might be a strong and independent predictor for Mets in an urban Chinese population. The incidence of Mets increased with AIP elevated in men while not in women.     

Evaluation of the Protective Efficacy of a Fused OmpK/Omp22 Protein Vaccine Candidate against Acinetobacter baumannii Infection in Mice

正Acinetobacter baumannii(A.Baumannii)is an emerging opportunistic pathogen responsible for hospital-acquired infections,and which now constitutes a sufficiently serious threat to public health to necessitate the development of an effective vaccine.In this study,a recombinant fused protein named Omp K/Omp22 and two individual proteins Omp K and Omp22 were obtained using recombinant expression and Ni-affinity purification.     

郭现辉运用“益气通经”指针推拿法治疗功能性腹胀

功能性腹胀主要发病机制为中焦气机不利,运化升降失常,属本虚标实之证,与肝、脾、胃三脏关系密切。郭现辉教授在辨证思想体系指导下,基于该病本虚标实之证,采用"益气通经"推拿法治疗功能性腹胀。根据经脉所过,主治所及的思想,该法主要作用于腹部任脉经穴,以运行周天,调和阴阳。操作手法上以指针法重点按揉气海穴,发挥气海主治一切气机之病的作用,结合旋推法施术上、中、下脘穴,最后与摩腹法相配合达到补益元气、通经调腑、畅达气机、消胀除满的作用。     

Leukopenia in alcoholics

Nine leukopenic episodes were studied in six alcoholics without coexistent bacterial infection, splenomegaly or megaloblastic erythropoiesis. The number of mature neutrophils was reduced in the blood and bone marrow, and the marrow granulocyte reserve was decreased. Serum unsaturated vitamin B₁₂-binding capacities were low, and muramidase activities were normal. Serum vitamin B₁₂ was normal; serum folate was low in five and normal or high in three. The reduced leukocyte count in blood and bone marrow, as well as the decreased granulocyte reserve and serum unsaturated vitamin B₁₂-binding capacity, returned to normal within two weeks without specific therapy. These findings suggest that prolonged and excessive consumption of alcohol may suppress myelopoiesis in man.     

药品市场“过票”行为成因与危害研究

目的:为整顿和规范我国药品市场秩序提供参考。方法:采取资料查询、现场调查、座谈讨论等方法对"过票"行为进行调查分析。结果:通过对"过票"手段的微观分析,对"过票"行为进行了定义,并系统地研究了"过票"现象,揭示了该行为的成因及危害。结论:杜绝药品市场"过票"行为有利于人民群众用药安全。