Altered neocortical tactile but preserved auditory early change detection responses in Friedreich ataxia

ObjectiveTo study using magnetoencephalography (MEG) the spatio-temporal dynamics of neocortical responses involved in sensory processing and early change detection in Friedreich ataxia (FRDA).MethodsTactile (TERs) and auditory (AERs) evoked responses, and early neocortical change detection responses indexed by the mismatch negativity (MMN) were recorded using tactile and auditory oddballs in sixteen FRDA patients and matched healthy subjects. Correlations between the maximal amplitude of each response, genotype and clinical parameters were investigated.ResultsEvoked responses were detectable in all FRDA patients but one. In patients, TERs were delayed and reduced in amplitude, while AERs were only delayed. Only tactile MMN responses at the contralateral secondary somatosensory cortex were altered in FRDA patients. Maximal amplitudes of TERs, AERs and tactile MMN correlated with genotype, but did not correlate with clinical parameters.ConclusionsIn FRDA, the amplitude of tactile MMN responses at SII cortex are reduced and correlate with the genotype, while auditory MMN responses are not altered.SignificanceSomatosensory pathways and tactile early change detection are selectively impaired in FRDA.     

酷似弥漫浸润型胃癌的深在性囊性胃炎1例

酷似弥漫浸润型胃癌的深在性囊性胃炎1例，经胃镜、CT、胃肠造影等检查均提示胃癌可能，后经超声内镜深挖活检、手术病理证实为深在性囊性胃炎。     

Psychodynamics and Sexual Object Choice. II

This essay addresses some of the essential paradoxes inherent in the training of psychoanalysts. A variety of perspectives are considered on how best to become an expert in a field of study where the essential focus is on what is not yet known.     

浅谈地市级药品检验所人才培养与科研设想

目的 探讨地市级药品检验所人才培养及科研设想。方法 通过分析新时期药品检验所职能范围的转变，提出加强人才培养及科研工作的重要意义。结果与结论 重视人才培养，加强科研合作，有利于实现药品检验所从传统检验型向科研创新型的转变。     

Single priming dose of meningococcal group C conjugate vaccine (NeisVac-C) in infants

Since the introduction of the meningococcal C conjugate (MCC) vaccine in the pediatric population in 1999, numerous clinical studies have confirmed the immunogenicity and safety of the NeisVac-C^® vaccine, and several have observed a strong immune response after a single priming dose, which could be successfully boosted. Maximizing protection of infants with as few vaccine doses as possible would increase the general acceptability of the immunization strategies and support broader coverage without increasing vaccination costs.     

Safety and pharmacokinetics of Alpha-1 MP (Prolastin®-C) in Japanese patients with alpha1-antitrypsin (AAT) deficiency

Background

Alpha₁-Proteinase Inhibitor, Modified Process (Alpha-1 MP) is used for augmentation therapy in alpha1-antitrypsin deficiency (AATD), an extremely rare disease in Japan. Weekly doses of 60?mg/kg Alpha-1 MP have been shown to be safe and well tolerated in non-Japanese subjects, but the safety and pharmacokinetics (PK) have not been evaluated in Japanese subjects. The objectives of this study were to evaluate the safety and PK of 60?mg/kg Alpha-1 MP administered by weekly IV infusions over 8 weeks in Japanese subjects with AATD.

防聋治聋医疗机构调查与对策探讨

目的:深入了解全国防聋治聋医疗资源及相关工作情况,探讨今后防聋治聋发展对策。方法:采用问卷调查法进行,由原卫生部下发文件,通过全国各省相关主管部门转发至相关防聋治聋医疗机构,通过网上填写报送形式进行汇总。结果:通过调查发现,国内防聋治聋工作取得了一定进步,但仍存在诸多不足,如防聋治聋医疗机构分布不均衡、听障预防工作薄弱、防聋治聋人才队伍缺乏、人才分布与结构不合理等。结论:发展国内防聋治聋事业需要国家顶层设计,由卫生行政部门牵头,多个相关部门机构联合从制定和完善相关管理机制、加强人员培训教育、进一步加强听力障碍流行病学研究等方面进一步推动防聋治聋工作。     

我国外资医疗机构准入制度相关问题研究

上海自贸区允许外商试点建立独资医疗机构,这是国内国际医疗服务贸易市场开放的一部分。当前国内设立外商独资医疗机构还面临一些现实问题与政策困境,外资医疗机构在投资审批、设备购买等方面程序复杂,缺乏配套医疗保险、面临人才匮乏等。未来应当以精细化的配套措施推进医疗服务市场的准入,为外资医疗机构提供法律、人力资源和医疗保险等方面支持。     

柳州市基层孕产妇保健服务能力现状调查

目的了解柳州市基层孕产妇保健服务能力现状,为卫生行政部门制定相关政策提供参考依据。方法调查柳州市所有社区卫生服务中心和乡镇卫生院孕产妇保健服务人力资源配置情况和设施设备情况。结果柳州市29所社区卫生服务中心和94所乡镇卫生院全部参与调查,共有234名产检医师,其中专职产检医师占78.60%,学历以大专及以下为主(70.78%),职称以初级职称为主(61.73%),高级职称有16人,163人(67.08%)有《母婴证》,138人(56.79%)到上级机构进修过,工作10年以上产检医师占63.79%。121所机构(98.37%)具有产检室、妇检室和候检区,118所机构(95.93%)具备基本的产检设备,119所机构(96.75%)具备实验室检测能力。结论柳州市基层医疗保健机构孕产妇保健服务能力有待提高,建议加强产科人员培养,增加人员和设备投入,保障基层孕产妇保健服务质量。     

Bridging non-human primate correlates of protection to reassess the Anthrax Vaccine Adsorbed booster schedule in humans

Anthrax Vaccine Adsorbed (AVA, BioThrax^®) is approved for use in humans as a priming series of 3 intramuscular (i.m.) injections (0, 1, 6 months; 3-IM) with boosters at 12 and 18 months, and annually thereafter for those at continued risk of infection. A reduction in AVA booster frequency would lessen the burden of vaccination, reduce the cumulative frequency of vaccine associated adverse events and potentially expand vaccine coverage by requiring fewer doses per schedule. Because human inhalation anthrax studies are neither feasible nor ethical, AVA efficacy estimates are determined using cross-species bridging of immune correlates of protection (COP) identified in animal models. We have previously reported that the AVA 3-IM priming series provided high levels of protection in non-human primates (NHP) against inhalation anthrax for up to 4 years after the first vaccination. Penalized logistic regressions of those NHP immunological data identified that anti-protective antigen (anti-PA) IgG concentration measured just prior to infectious challenge was the most accurate single COP.In the present analysis, cross-species logistic regression models of this COP were used to predict probability of survival during a 43 month study in humans receiving the current 3-dose priming and 4 boosters (12, 18, 30 and 42 months; 7-IM) and reduced schedules with boosters at months 18 and 42 only (5-IM), or at month 42 only (4-IM). All models predicted high survival probabilities for the reduced schedules from 7 to 43 months. The predicted survival probabilities for the reduced schedules were 86.8% (4-IM) and 95.8% (5-IM) at month 42 when antibody levels were lowest. The data indicated that 4-IM and 5-IM are both viable alternatives to the current AVA pre-exposure prophylaxis schedule.