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11.
WangZhan LiuCuiping FangJinian 《中国药学》2001,10(2):57-60
H3, a homogeneous acidic polysaccharide was obtained from the seeds of Cuscuta chinensisLam. Its structure was characterized for the first time by chemical and spectroscopic methods to be a highly branchedheteropolysaccharide with mean molecular weight of more than lxl0^6. It was composed of 1,6-1inked-β-D Galp, 1,4-linked-β-D Galp, 1,4-1inked-β-D GalA, 1,3,6-1inked-β-D Galp and 1,2,4-1inked Rhap, with branching points at O-2or 0-4 of 1,2,4-1inked Rhap and 0-3 of 1,3,6-1inked-β-D Galp. Its side chains included 1-1inked Araf, 1,5-1inked Arafand 1,3,5-1inked Araf at O-3 of 1,6-1inked Galp in the main chain. 相似文献
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The aerial parts of Cressa cretica L. yielded five flavonoids that were identified as quercetin (1), quercetin-3-O-glucoside (2), kampferol-3-O-glucoside (3), kampferol-3-O-rhamnoglucoside (4), and rutin (5). All of the isolated flavonoids were identified by spectroscopic methods (UV, FAB-MS, 1H NMR and 13C NMR) and in comparison with literature data. The isolated flavonoids, except quercetin, are reported here for the first time from Cressa cretica L. 相似文献
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Two new resin glycosides, batataosides I (1) and II (2), and five known compounds, friedelin (3), scopoletin (4), octadecyl caffeate (5), β-sistosterol (6) and daucosterol (7), were isolated from the roots of Ipomoea batatas. Their structures have been determined based on the chemical and spectral data. Batataosides I and II have novel structures because the core simonic acid B was esterised with cinnamic acid for the first time, and three different substituent esterification groups in one resin glycoside is scarce. The absolute configuration of the aglycone was elucidated to be S by Mosher's method. 相似文献
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首次从中药菟丝子 (Cuscuta chinedsis Lam.) 中得到一均一酸性多糖H3,并采用化学及光谱方法对其结构特征进行了研究。结果表明该多糖为一多分枝的复杂多糖,由1,6-linked- β -D Galp, 1,4-linked-β-D Galp, 1,4-linked-β-D GalA, 1,3, 6-linked-β-D Galp 及1,2,4-linked Rhap 组成,分枝点位于1,2,4-linked Rhap 的O-2 或 O-4以及1,3,6-linked-β-D Galp 的O-3位,并以1-linked Galp 为末端。侧链由1-linked Araf, 1,5-linked Araf 和 1,3,5-linked Araf 构成,并连接于主链的1,6-linked Galp 的O-3位。 相似文献
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Senthi Mahibalan Maria Stephen Rohan Thekkedathu Nethran Rukaiyya Khan 《Pharmaceutical biology》2016,54(12):2851-2856
Context: Evolvulus alsinoides Linn. (Convolvulaceae), well known as shankhpushpi in Ayurvedic text, is traditionally used for several healing purposes.Objective: A comparative evaluation of dermal wound healing potential of acidic and basic alkaloid enriched-ointment (AAO and BAO) of aerial parts of E. alsinoides versus pure alkaloid, betaine (BEO), was undertaken.Material and methods: The effect of topical application (50?mg/animal/day) of AAO-1%, AAO-2%, BAO-1%, BAO-2%, BEO-0.5% and BEO-1% was assessed through excision (14 days) and incision (10 days) models on rats. The percentage wound contraction, total protein content, and breaking strengths were determined followed by histopathological studies.Results and discussion: The total alkaloid in acidic and basic alkaloid enriched fractions was found to be 0.1114 and 0.1134?μg/mL, respectively. Thus, 0.1528, 0.3056, 0.1380 and 0.2459?μg of total alkaloid were estimated to be present in AAO-1%, AAO-2%, BAO-1% and BAO-2%, respectively. AAO and BAO promoted wound healing activity significantly in both the models. Higher rate of wound contraction (p?<?0.001) with significant increase in protein content in the treatment groups (from 2.32 to 2.55) demonstrated stimulation of cellular proliferation and epithelization, which was further supported by histopathological reports. High skin breaking strength (mean value 393 in control was increased to the range of 535–572 in treated groups) proved a significant (p?<?0.001) wound healing potential of E. alsinoides. Early dermal and epidermal regeneration in drug-treated groups also confirmed the positive effect.Conclusion: Observation of higher healing power of alkaloid enriched-ointment compared with single alkaloid ointment corroborated the synergy mechanism. 相似文献
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Taiana Magalhães Pierdoná Nathalia Rocha Lima Raony Cássio Millet Rodrigues Jonas Pires Teixeira Romélia Pinheiro Gonçalves Juvenia Bezerra Fontenele Silvânia Maria Mendes Vasconcelos Glauce Socorro de Barros Viana Luzia Kalyne Almeida Moreira Leal 《Journal of ethnopharmacology》2014
Ethnopharmacological relevance
Operculina macrocarpa is an ornamental climbing plant of the Northeastern Brazil extensively used in traditional medicine as depurative of the blood and for the treatment of thrombosis. To investigate the antiplatelet and anticoagulant potential of Operculina macrocarpa and to determine the possible mechanisms of action.Material and methods
The Operculina macrocarpa tincture (OMT) was characterized by the polyphenol content and chromatographic profile established by HPLC with detection and quantification of three phenol acids (caffeic, clorogenic and gallic acids). The human platelet aggregation was induced in vitro by the agonists ADP, collagen, thrombin, epinephrine or arachidonic acid, and the antiplatelet effect of OMT was evaluated in the presence or absence of aspirin (a nonselective inhibitor of cyclooxygenase), pentoxifylline (a phosphodiesterase inhibitor), ticlopidine (a P2Y12 purinoceptor antagonist) or ODQ (a selective inhibitor of guanilate cyclase). The effect of OMT on the partial thromboplastin time, prothrombin time and bleeding time were investigated on human or rat plasma.Results
The strongest antiplatelet effect of OMT (50–400 µg/mL) was observed on the ADP- induced aggregation with inhibitions up to 55%, while among others agonists (epinephrine, collagen, thrombin and arachidonic acid) maximal inhibitions reached by OMT (200 µg/mL) were on platelet aggregation induced by collagen (18%) or epinephrine (20%). The antiplatelet effect of OMT (400 µg/mL) was comparable to aspirin, a nonspecific inhibitor of cyclooxygenase. The ticlopidine and pentoxifylline increased 5.1 and 3.8 fold the inhibitory effect of OMT on ADP-induced platelet aggregation, respectively. On the other hand, l-arginine, ODQ and aspirin showed a slightly or no effect on antiplatelet effect of OMT. The bleeding time in rats was significantly increased by OMT, but the tincture did not interfere on the activated partial thromboplastin or prothrombin time in human plasma.Conclusions
This study showed that the tincture of Operculina macrocarpa has antiplatelet effect that cannot be attributed to a single biochemical mechanism and at least part of it cannot be related to the OMT inhibition of P2Y12 purinergic receptors. 相似文献18.
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The stereochemistry of consabatine, which was isolated from the roots of Convolvulus sabatius Viv. as a novel natural compound, has now been determined by the synthesis of its Mosher esters. Consabatine was found to be 1′R-configurated. 相似文献