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61.
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Hans J. Seitz Wilhelm Krone Harald Wilke Wolfgang Tarnowski D. Carsten B. Dunkelmann A. Harneit 《Pflügers Archiv : European journal of physiology》1981,389(2):115-120
The effect of acute cold exposure on the concentration of glucagon in the blood was investigated in man and in intact and adrenalectomized rats.In man fasted overnight acute cold exposure, which caused a twofold increase in O2-consumption resulted in a rapid rise in plasma glucagon. The levels of insulin and blood glucose remained unaltered, while the concentration of serum free fatty acids and -hydroxybutyrate increased.In fasted intact rats acute cold exposure lead to similar effects. A close parallelism between the rise in plasma glucagon and the concentration of hepatic cycloAMP was observed. Adrenalectomy did not impair the cold induced rise in plasma glucagon and hepatic cycloAMP.It is concluded that acute cold exposure caused a rapid rise in the concentration of plasma glucagon leading to an increase in the concentration of hepatic cycloAMP, thus enhancing the rate of hepatic gluconeogenesis and ketogenesis. As these alterations were similar in the absence of glucocorticoids and medulla-derived catecholamines, it is suggested that glucagon may play a role in the metabolic adaptation to acute cold exposure. 相似文献
63.
Gregory K. Snyder Caroline Farrelly Joseph R. Coelho 《European journal of applied physiology》1992,65(2):158-163
Summary The effects of changes in oxygen supply and oxygen demands on fiber cross-sectional areas, capillary dersities and capillary to fiber ratios were determined in three skeletal muscles of rat. The muscles examined were the vastus lateralis, soleus, and diaphragm. Reduced oxygen supply was produced by subjecting rats to ambient hypoxia, and increased oxygen demands were produced by subjecting rats to low ambient temperatures or treatment with thyroxin. Capillaries were visualized by injecting fluorescent dyes into the circulation. Muscles were quick frozen at resting lengths to preserve normal fiber geometry and were subsequently sectioned on a cryostat. All of the muscles sampled from animals in the experimental groups had elevated capillary densities. However, capillary to fiber ratios were not increased significantly in any muscle, for any experimental condition. Thus, all of the observed differences in capillarity were due to changes in the intrinsic rate of muscle fiber growth. Further, the relations of capillary density and capillary to fiber ratio to fiber area were the same as those obtained during normal maturation, suggesting that capillary growth is closely linked to the intrinsic rate of fiber growth. 相似文献
64.
伤寒史学研究成果简述 总被引:1,自引:0,他引:1
万晓刚 《Zhonghua yi shi za zhi (Beijing, China : 1980)》2000,30(4):211-214
建国以来有关伤寒史学的研究成果表现在相关人物、相关著作、相关事件、学术关系及阶段特征五个方面。前期研究成果 ,尚不足以充分展示伤寒学历史地位和现实意义 ,更无充分依据昭示其未来之发展方向 ,因而有必要继续深入开展伤寒史学研究 相似文献
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冷损伤血管NO合成酶活力的变化及其生物学意义 总被引:7,自引:0,他引:7
目的 观察不同程度冷损伤血管NO合成酶(NOS)活力的变化,并研究超氧化物歧化酶(SOD)和VitC对这各变化影响。方法分离Wistar大鼠主动脉,并在PBS培育培养1小时,然后使其暴露于-20℃环境。以全自动生化分析仪测定血管培养液中乳酸脱氢酶(LDH)活力,以Griess化学法观测血管NOS活力,以肾上腺肾自氧化法血管SOD活力。结果 当血管暴露于-20℃环境1、2、4分钟后,血管2液中LDH 相似文献
69.
Gamma Knife Radiosurgery of the Glomus Jugulare Tumour – Early Multicentre Experience 总被引:3,自引:0,他引:3
Liscák R Vladyka V Wowra B Kemeny A Forster D Burzaco JA Martinez R Eustacchio S Pendl G Regis J Pellet W 《Acta neurochirurgica》1999,141(11):1141-1146
Leksell Gamma Knife was used to treat 66 patients with glomus jugulare tumour at 6 European sites between 1992-1998. The age of the patients ranged between 18-80 years (median 54 years). Gamma Knife radiosurgery was a primary treatment in 30 patients (45. 5%). Open surgery preceded radiosurgery in 24 patients (36.4%), embolisation in 14 patients (21.2%) and fractionated radiotherapy in 5 patients (7.6%). The volume of the tumour ranged 0.5-27 cm(3) (median 5,7 cm(3)). The minimal dose to the tumour margin ranged between 10-30 Gy (median 16.5 Gy). After radiosurgery 52 patients were followed, the follow up period was 3-70 months (median 24 months). Neurological deficit improved in 15 patients (29%) and deteriorated in 3 patients (5,8%), one transient and two persistant. Neuroradiological follow up using MRI or CT was performed in 47 patients 4-70 months (median 24 months) after radiosurgery. Tumour size decreased in 19 patients (40%) while in the remaining 28 patients (60%) no change in the tumour volume was observed. None of the tumours increased in volume during the observation period. Control angiography was performed in 6 patients. Pathological vascularisation completely disappeared in one patient, reduced in two and there was no change in the remaining three. Radiosurgery proves to be a safe treatment for glomus jugulare tumour with no mortality and no acute morbidity. Because of its naturally slow growth rate, up to 10 years of follow up will be necessary to establish a cure rate after radiosurgery for these lesions. 相似文献
70.
伽玛刀的医学技术评估 总被引:9,自引:0,他引:9
伽玛刀是世界上最昂贵的医疗设备之一,我国从1992年开始引进。1995年卫生部等联合发文暂缓装备。为了规范提供方和患方的行为,以及为卫生行政部门提供决策依据,我们开展了伽玛刀的技术评估。在评估前拟定评估步骤,然后确定评估内容与方法。评估结果,国外1994年有56台伽玛刀,平均每台治疗190例,治疗病种是:动静脉畸型病人占32%,肿瘤病人占65%,功能性疾病占2%。我国13台伽玛刀到1995年底共治病人7000例,前6位病种是转移瘤等,虽然比例和顺位与世界有差异,但病例分析结果完全一致。 相似文献