Time to significant pain reduction following DETP application vs placebo for acute soft tissue injuries

Abstract

Objective:

Nonsteroidal anti-inflammatory drugs (NSAIDs) provide fast and effective acute pain relief, but systemic administration has increased risk for some adverse reactions. The diclofenac epolamine 1.3% topical patch (DETP) is a topical NSAID with demonstrated safety and efficacy in treatment of acute pain from minor soft tissue injuries. Significant pain reduction has been observed in clinical trials within several hours following DETP application, suggesting rapid pain relief; however, this has not been extensively studied for topical NSAIDs in general. This retrospective post-hoc analysis examined time to onset of significant pain reduction after DETP application compared to a placebo patch for patients with mild-to-moderate acute ankle sprain, evaluating the primary efficacy endpoint from two nearly identical studies.     

内灸式激光针灸针治疗寒湿腰痛的疗效观察

目的观察内灸式激光针灸针治疗寒湿腰痛的临床疗效。方法寒湿腰痛患者68例,随机分为试验组和对照组,每组34例。试验组采用内灸式激光针灸针治疗;对照组采用传统针刺法治疗。治疗后应用疼痛视觉模拟量表（visual analogue scale,VAS）和Oswestry功能障碍指数（oswestry dability index,ODI）评估疗效。结果 （1）VAS评分：两组患者治疗后与治疗前比较,VAS评分均显著下降（P〈0.05）;第1次治疗后两组VAS评分分别为：试验组（3.95±1.89）分;对照组（4.94±2.05）分,两组比较差异有显著意义（P〈0.05）。治疗10次后两组的VAS评分分别为：试验组（3.50±1.18）,对照组（3.69±1.27）分,两组比较差异无显著意义（P〉0.05）。（2）ODI评分：第1次治疗后两组患者ODI评分分别为：试验组（16.28±7.82）分,对照组（16.14±7.18）分,两组比较差异无显著意义（P〉0.05）。治疗10次后两组患者的Oswestry评分均显著下降,与治疗前比较差异有显著意义（P〈0.05）,组间比较差别无显著意义（P〉0.05）。结论内灸式激光针灸针法治疗寒湿腰痛即时止痛效果优于传统针刺疗法,但治疗1次对提/携物、坐、行走各项功能无明显改善;治疗1个疗程后两种疗法皆可止痛及改善各种功能。     

Behavioral Intervention in Children with Functional Abdominal Pain Disorders: A Promising Option

Background The objectives of this study were to identify and classify patients with functional abdominal pain disorders (FAPD) into its various subtypes as per the Rome IV criteria and to evaluate the underlying psychological factors and the effect of behavioral intervention in children with FAPD.Methods A validated Questionnaire on Pediatric Gastrointestinal Symptoms (QPGS) based on Rome IV criteria was used to identify and classify children presenting with abdominal pain. The children diagnosed as having FAPD were referred for psychological screening to evaluate for underlying psychosocial problems. The scales namely Pediatric Anxiety Rating Scale (PARS), Depression self-rating scale (DSRS), and Visual Analog Scale (VAS) were administered to children to assess the response of the child to behavioral therapy. Results Of 100 children, 32, 26, 22, and 20% of children belonged to the subtypes of functional abdominal pain—not otherwise specified, abdominal migraine, irritable bowel syndrome, and functional dyspepsia, respectively. The most common associated psychosocial factors were academic burden, poor financial condition, exam-related stress, and bullying at school. The influence of behavioral therapy was statistically significant (P < .05). The mean (±standard deviation) PARS and DSRS scores were significantly reduced at 3 months of follow-up.Discussion The most common subtypes reported were functional abdominal pain—not otherwise specified and abdominal migraine. Psychological factors such as academic burden, poor financial condition, exam-related stress, and bullying at school need to be ruled out in children with this condition. Non-pharmacological intervention such as behavioral therapy can confer a remarkable improvement in the symptoms of children with FAPD.     

伴有心血管代谢疾病的眩晕患者的疗效影响因素

目的 探讨伴有心血管代谢性疾病的眩晕/头晕患者的临床特征和近期结局影响因素.方法 本研究纳入了2018年10月至2020年1月之间连续就诊于武汉同济医院眩晕专科门诊的伴有心血管代谢性疾病的眩晕/头晕患者.随访时获得的患者眩晕/头晕症状视觉模拟量表(Visual analogue scale,VAS)评分作为结局指标并按...     

Effects of 1α,25-dihydroxy-16ene, 23yne-vitamin D3 on osteoblastic function in human osteosarcoma SaOS-2 cells: differentiation-stage dependence and modulation by 17-β estradiol

We compared the separate effects of 1α,25-dihydroxyvitamin D₃ (1α,25(OH)₂D₃) and its analog, 1α,25-dihydroxy-16ene,23yne-vitamin D₃ (1α25(OH)₂-16ene,23yne-D₃), as well as their interactions with 17-β estradiol (E₂) in our human osteosarcoma SaOS-2 cell models representing two stages of differentiation, the SaOS+DEX and SaOS-DEX cells. SaOS+DEX cells have been previously shown to express higher PTH-stimulated adenylate cyclase (PTH-AC) and basal alkaline phosphatase (ALP) activities compared with SaOS-DEX cells. ALP: In SaOS+DEX cells, 0.1 nmol/L analog, but not 1α,25(OH)₂D₃, increased ALP activity 1.7-fold (p < 0.05). Instead, 1 nmol/L 1α,25(OH)₂D₃ increased ALP 1.4-fold (p < 0.05). In these cells, E₂ enhanced 1α,25(OH)₂D₃-stimulated ALP activity (ANOVA, F = 51.22, p <0.0001), while inhibiting the effect of the analog. [³H]-Thymidine uptake: In SaOS+DEX cells, 1α,25(OH)₂D₃ had biphasic effects (ANOVA, F = 13.08, p < 0.0001), which were not altered by E₂. In contrast, the analog was stimulatory only with E₂ (ANOVA, F = 3.59, p < 0.025). Osteocalcin (OC): 1α,25(OH)₂D₃ and its analog stimulated OC production in SaOS-DEX cells with smaller effects in SaOS+DEX cells. In SaOS-DEX cells, E₂ enhanced the effect of 1α,25(OH)₂D₃, but not that of the analog. PTH-AC: In SaOS-DEX cells, 100 nmol/L analog inhibited PTH-AC activities by 50% (p < 0.01), whereas 1α,25(OH)₂D₃ had little effect. In SaOS+DEX cells, both compounds inhibited PTH-AC ≈ 35%. E₂ inhibited the effect of the analog in SaOS-DEX cells, but enhanced the effects of both compounds in SaOS+DEX cells. These results show that the analog 1α,25(OH)₂-16ene,23yne-D₃ was effective in regulating osteoblastic function; its effects were modulated by E₂ and dependent upon the stage of osteoblast differentiation.     

A technique for processing coronary hemodynamic data with a small hybrid computing system

This report describes the program for utilizing a small hybrid computing system to process coronary arterial flow and pressure signals obtained from chronically instrumented, conscious animals and discusses the advantages and disadvantages of the hybrid approach. Extensive analog preprocessing using parallel logic facilitates formation of data during the experiment and minimizes later editing. Moreover, it allows the digital portion of the program to be much smaller and more general than similar applications using only digital systems. Final output consists of an ink-jet recording of the analog signals, a printout of the digital results, and CalComp plots.     

新型胺烷基酯类取代的顺式反式长春西汀衍生物的合成(英文)

目的:合成一系列新型胺烷基酯类取代的顺式反式长春西汀衍生物以便研究其构效关系。方法:以顺式反式阿朴长春胺酸为起始原料, 通过三步反应较为简便地得到了目标产物。结果:一共合成了24个新型胺烷基酯类取代的顺式反式长春西汀衍生物。结论:建立了一种简便合成新型胺烷基酯类取代的顺式反式长春西汀衍生物的通用方法。     

Amplifications and applications of Pennebaker's analogic to digital model in health promotion,prevention, and psychotherapy

This article expands on James Pennebaker's original model in expressive writing, going from an Analogically unclear and unspecified experiential mass (A) to a Digital specification in words (D). Amplifications of this model are found in philosophy, psychodynamic theory and in Salience learning theory. Applications of this model involve expressive writing, going from ambiguous experiences (A) to using the Dictionary (D), and responding to Sentences with strong psychological impact (S). The undefined and ill‐defined analogical mass is constituted by traumas in Pennebaker's work and hurt feelings in L'Abate's and Vangelisti's works. Implications of these approaches for the practice of health promotion, prevention and psychotherapy are discussed. Copyright © 2010 John Wiley & Sons, Ltd. Key Practitioner Message: ? This article points to the presence of internal feelings that are produced by abusive, painful, hurtful or of negatively perceived events in a person's life at various levels of awareness, from deeply unconscious, semi‐conscious, conscious but not spoken, and conscious and spoken. ? Consequently, there are at least four different techniques that can be used by practitioners to elicit and facilitate the emergence of these feelings through. ? Traditional talk‐based face‐to‐face psychotherapy focused mostly on those feelings rather than other distracting or tangential topics. ? Expressive writing, the Pennebaker's paradigm about past traumas for 15 to 20 minutes a day for 4 consecutive days. ? Programmed distance writing with interactive practice exercises or work‐books specifically focused on hurt feelings using a matching Informed Consent Form to be signed by participants before introducing any therapeutic approach to elicit hurt feelings. ? Administration of sentences with strong psychological impact that may be related to hurt feelings.     

A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee

Aflapin^® is a novel synergistic composition derived from Boswellia serrata gum resin (Indian Patent Application No. 2229/CHE/2008). Aflapin is more efficacious as an anti-inflammatory agent compared to the existing Boswellia products, 5-Loxin^® and traditional 65% Boswellia extract. A 30-day, double-blind, randomized, placebo-controlled study was conducted to validate the efficacy of Aflapin^® in the management of clinical symptoms of osteoarthritis (OA) of the knee (Clinical trial registration number: ISRCTN69643551). Sixty eligible OA subjects selected through screening were included in the study. The subjects received either 100 mg (n=30) of Aflapin^® or placebo (n=30) daily for 30 days. Each subject was evaluated for pain and physical functions by using the standard tools (visual analog scale, Lequesne''s Functional Index, and Western Ontario and McMaster Universities Osteoarthritis Index) at the baseline (day 0), and at days 5, 15 and 30. A series of biochemical tests in serum, urine and hematological parameters established the safety of Aflapin. The observations suggest that Aflapin conferred clinically and statistically significant improvements in pain scores and physical function scores in OA subjects. Aflapin provided significant improvements in pain score and functional ability in as early as 5 days of treatment. In conclusion, our observations suggest that Aflapin is a safe, fast acting and effective alternative intervention in the management of OA.