谷康泰灵对犬骨关节炎修复作用的实验研究

目的　探讨谷康泰灵对动物骨关节炎的修复作用。方法　实验用家犬 16只 ,将动物分成A、B两组。用Hulth法建立动物模型 ,实验组 (A组 ) 8只犬 ,术后当日开始给药 ,每日 1次肌注谷康泰灵注射液 2ml,共 8周 ;对照组 (B组 ) 8只狗 ,术后当日开始肌注生理盐水 2ml,每日 1次 ,共 8周。术后观察动物膝关节活动情况 ,并分别于用药 4周、 8周后 ,实验组及对照组各处死 4只动物 ,对膝关节标本进行犬体观察、光镜观察、电镜观察。结果　动物跛行情况 :实验组较对照组轻。膝关节标本肉眼观察 :实验组 4周时 ,关节面光滑有光泽 ,无明显缺损和新生物 ,至 8周时关节面不光滑 ,色泽暗 ,软骨透明度低 ,有细小缺损和少许新生物 ,这些变化均比对照组轻。光镜及电镜所见显示随时间延长 ,实验组结构逐渐坏变 ,但较对照组轻 ,实验组与对照组比较 ,P <0 0 5 ,有显著性差异。结论　谷康泰灵注射液能明显减缓骨关节炎的发生     

Computerized psychiatric diagnoses based on euclidean distances: a Chinese example.

Current diagnostic methods in psychiatry use sequential logical decision rules that generate a single diagnosis. Insufficient attention has been paid to parallel methods that can simultaneously determine the relative probability of many diagnoses. This study installed 45 items from various symptom scales on a portable computer and applied a euclidean distance formula to generate immediate diagnoses based on responses to the items. The reliability and validity of the method were assessed using Chinese psychiatric inpatients. Interrater reliability was excellent (kappa = 0.91) and 3-week test-retest reliability was fair (k = 0.50). The concordance of this method with clinicians' diagnoses and with diagnoses based on standardized Chinese diagnostic criteria was excellent (k = 0.73 and 0.76). Concordance with DSM-III-R diagnoses and ICD-10 diagnoses was fair (kappa = 0.55 and 0.65). The clinical utility of such parallel methods of psychiatric diagnosis deserves further evaluation.     

雌激素对大鼠骨性关节炎影响的实验研究

目的　了解雌激素水平改变对雌性大鼠骨性关节炎的影响。　方法　 SD大鼠 4 0只 ,采用膝关节制动制作骨性关节炎及同时切除卵巢的方法制作绝经期大鼠模型。实验分为 4组 , 组为正常对照组 ; 组为单纯关节固定组 ; 组为关节固定加卵巢切除组 ; 组在 组基础上同时给予 0 .80 mg/ (kg· d)己烯雌酚 ,连续 4周。 1个月后进行骨性关节炎病理学观察、评分和血清骨钙素检测。　结果　 组 (5 .72± 0 .6 4 )μg/ L血清骨钙素明显高于 组 (3.5 0±0 .39)μg/ L及 组 (3.95± 0 .4 4 )μg/ L。骨性关节炎、关节软骨和滑膜组织病理学评分 组 (10 .83± 4 .35、4 .2 1± 2 .0 3) , 组 (15 .32± 3.4 2、7.6 2± 3.4 2 ) , 组 (12 .6 5± 2 .73、5 .4 6± 1.2 3)。　结论　雌性大鼠切除卵巢可加重骨性关节炎的病理改变 ,而应用己烯雌酚替代后可延缓骨性关节炎的病理过程。雌激素可能在延缓骨性关节炎的发病过程中发挥重要作用。     

Infrequent Mutation of p53 Gene in Human Renal Cell Carcinoma Detected by Polymerase Chain Reaction Single-strand Conformation Polymorphism Analysis

Mutation of the p53 gene, which plays an important role in the genesis of diverse human cancers, was investigated in 23 surgical specimens of human renal cell carcinoma using the polymerase chain reaction single-strand conformation polymorphism method of analysis. Only one of the 23 tumors (4.3%) carried a mutated p53 gene, which was present in exons 7–8. Direct DNA sequencing confirmed a point mutation at codon 276 (GCC to CCC) resulting in a substitution of alanine for proline. No specific clinicopathological characteristics were observed in the case with the p53 gene mutation in human renal cell carcinoma. These observations suggest that mutation of the p53 gene is rare and thus does not contribute significantly to the genesis of this tumor.     

苏子油与a-亚麻酸

苏子油与ａ－亚麻酸王淑丽，陈济民沈阳药科大学药学系１１００１５目前，ｎ－３系不饱和脂肪酸的营养价值及生理、药理作用已日益引起人们的关注，许多学者在这方面进行了广泛深入的研究，其中研究得比较成熟的是鱼油中富含的二十碳五烯酸（ＥＰＡ）和二十二碳六烯酸（Ｄ...     

54例骨转移性肿瘤临床病理分析

总结５４例骨转移性肿瘤。本组骨转移性肿瘤在同期骨恶性肿瘤中占２８．５７％。年龄好发于３０～５９岁，男女之比１．８４：１。ｘ线表现以溶骨性病变为主。病理类型以转移性腺癌居多，占６２．９６％，原发灶明确的仅占３３．３３％。２年内死亡达７７．４２％。     

INTRA-OPERATIVE IMPLANT BRACHYTHERAPY IN THE MANAGEMENT OF SOFT-TISSUE SARCOMAS

Background : The management of localized soft-tissue sarcomas remains complex. This is a retrospective review of a single institution experience with manual afterloaded brachytherapy following intra-operative implantation of the tumour bed during surgery. Methods : Twelve patients over a 3-year period had resection for localized soft-tissue sarcomas and desmoids with insertion of intra-operative brachytherapy implants combined with resection for localized soft-tissue sarcomas. Manual afterloading of the implant with iridium wires was performed postoperatively in all patients. The low dose rate brachytherapy dose varied from 13 to 20 Gy. Supplementary external beam radiation was administered pre-operatively or postoperatively to bring the total dose of adjuvant irradiation to 60–65 Gy. Results : After a median follow-up period of 29 months, the 3-year local disease-free survival rate was 63%. The 3-year actuarial survival rate was 83%. There were no failures within the high-dose region of the implant, although two patients had locoregional failures adjacent to the tumour bed at the edge of the radiation field. Three patients developed distant metastases. Side effects were noted in five patients. Wound breakdown and delayed wound healing occurred in two patients. One patient required an amputation as a result of chronic non-healing and wound pain. Pathological fractures occurred in two patients. Those patients who did not develop wound breakdown had good cosmetic and functional outcomes. Conclusion : Intra-operative implantation of the tumour bed in combination with tumour resection for soft-tissue sarcomas results in a high degree of local control with acceptable complications. This modality offers the patient a high chance of avoiding a more radical surgical procedure such as limb amputation.     

Cycloid psychosis: regional cerebral blood flow correlates of a psychotic episode.

Eight patients meeting Leonhard's criteria for cycloid psychosis were investigated on repeated occasions during a psychotic episode, with regional cerebral blood flow measurements and clinical ratings. The results showed that, at admission to the hospital, when the patients were clinically exacerbated, the mean hemispheric blood flow was significantly elevated compared with values from a normal control group. The hemispheric blood flow level covaried significantly with the degree of clinical symptoms, such that the more elevated the cortical blood flow was, the more behaviorally disturbed was the patient. At discharge from the hospital, the patients had no residual symptoms and the cortical blood flow was normal. These findings differ distinctly from those commonly made in other psychoses, such as schizophrenia.     

髋臼旋转与转子间外翻联合截骨术治疗成人扁平髋骨关节炎

髋臼旋转与转子间外翻联合截骨术治疗成人髋臼发育不良合并股骨头扁平畸形继发的中期髋骨关节炎６例（６髋）。年龄２５～４７岁（平均３６．４岁）。男２例，女４例。均有半脱位和骨关节结构的变化，临床表现为行走疼痛和跛行。手术方法在ニノ宫旋转截骨术基础上进行部分改进。平均随访时间２．５年（１４～４２个月）。结果以Ｌａｃｋ的改良Ｔｎｉｓ标准评定，优４例，良２例。手术前后的形态变化对照Ｘ线片的Ｓｈａｒｐ角（示臼关节面倾斜度）、ＡＨＩ（示股骨头覆盖率）、ＩＣＤ和ＨＸ（示股骨头向外偏离度）、ＡＴＤ（示大转子高度）等指标，取得了明显的矫正效果。