红曲霉的抑菌活性物质与桔青霉素

综述红曲霉产生抑菌物质和桔青霉等方面的研究现状和新的进展。在红曲霉的次级代谢产物中，红曲色素、橙色素、ａｎｋａｌａｃｔｏｎｅ、ｍｏｎａｓｃｉｄｉｎＡ具有抑菌作用，而且ｍｏｎａｓｃｉｄｉｎＡ的化学结构与桔青霉素的化学结构类似。有必要对抑菌物质与桔青霉素之间的关系进行探讨研究     

四川省部分地区主粮中杂色曲霉菌及其毒素的污染调查

通过对四川省部分地区大米和小麦两种主粮中杂色曲霉菌（Ａ．ｖ）和杂色曲霉素（ＳＴ）污染调查，结果表明在大米和小麦中，Ａ．ｖ污染率分别为５．５％和１０．５％；ＳＴ污染率为５３．４％和６５．８％；ＳＴ平均含量为１５．５μｇ／ｋｇ和５８．６μｇ／ｋｇ。对不同地区和不同贮藏期粮食进行分析，Ａ．ｖ检出率越高，粮食中ＳＴ污染率和含量越高；贮藏期延长，Ａ．ｖ和ＳＴ检出率及ＳＴ含量增高。实验产毒表明所有Ａ．ｖ菌株均能产生ＳＴ，平均产毒量达７１９０．２μｇ／ｋｇ，证实Ａ．ｖ是ＳＴ形成的主要菌种     

Immunofluorescence serology. A tool for prognosis of Q-fever

The indirect immunofluorescence antibody test is currently the method of choice for Q-fever laboratory diagnosis. It permits the detection of IgG-, IgM-, and IgA-specific antibodies against the two phases of Coxiella burnetii. Sera from 20 cases of C. burnetii infection have been examined. Only total IgG against phase II were detected in cryptic infections. In acute Q-fever cases, the appearance of total IgG antibodies against phase I was a sign of aggravation, while IgM titers remained low. In subacute cases of Q-fever, anti-phase-I IgG titers were equal to or higher than anti-phase-II titers, and IgM against both phases were produced over a long time. Particularly high IgM titers were found in cases of granulomatous hepatitis. IgA antibodies against phase I were found in cases of Q-fever endocarditis, although the two cases that died had few or no IgA antibodies, despite very high IgG and IgM titers.     

Incidence of varying factors on the immunochemical behavior of alpha 1-acid glycoprotein

Electroimmunodiffusion methods of Laurell and radial immunodiffusion method of Mancini are compared for the qualitative and quantitative analysis of native and desialylated alpha 1-acid glycoprotein. Samples are incubated under different conditions at decreasing pH (3.5 to 0.5 pH units), with increasing ionic strength and with neuraminidase during different time intervals. Results show a pronounced decrease in electrophoretic mobility of alpha 1-acid glycoprotein treated either with acidic reagents or with neuraminidase (ionic strength has no effect). Such a procedure might involve chemical or enzymatic hydrolysis by which sialyl residues are removed. This hydrolysis implicates lower results in the estimation of the desialylated glycoprotein by electroimmunodiffusion. On the other hand, the amounts of alpha 1-acid glycoprotein evaluated by radial immunodiffusion are not modified after incubation. This is expected since diffusion and antigenic properties are not related to the sialic acid content. The data suggest that radial immunodiffusion, less accurate and sensitive than electroimmunodiffusion, is nevertheless more adequate for estimating native and desialylated alpha 1-acid glycoprotein.     

Transient ST segment elevation occurring without anginal pain. Correlations with Prinzmetal's angina.

Two cases presenting with episodes of marked ST segment elevation occurring with, but most often without, anginal pain are reported. The changes were recorded through continuous ECG monitoring during Prinzmetal's angina and in the course of myocardial infarction. Such transient asymptomatic ECG abnormalities reveal silent acute myocardial ischemia and are often unrecognized. However, they may lead to severe arrhythmias or myocardial infarction, and sudden deaths occurring in the course of ischemic heart disease are likely to be explained on this basis. Transient episodes of silent ST segment elevation similar to those occurring in Prinztal's angina have been reported in various circumstances. They bring into discussion the delimitations of variant angina pectoris.     

Gastric carcinoma treated by chemotherapy after resection: A controlled study

A prospective controlled study of combined chemotherapy with 5-fluorouracil, vinblastine and cyclophosphamide was conducted in 53 patients with radical resection for gastric carcinoma. The patients were divided into two groups, a control group of 26 patients and a chemotherapy group of 27 patients, that were similar in regard to age, sex, location of carcinoma, type of resection and pathologic findings. No significant differences in survival rate were observed between the control group and the chemotherapy groups.